Review
Chemistry, Inorganic & Nuclear
Magdalena Malecka, Anna Skoczynska, David M. Goodman, Christian G. Hartinger, Elzbieta Budzisz
Summary: This review highlights the progress in the development of ruthenium(II)/(III) complexes with flavone derivatives as potential therapeutic agents, focusing on their antimicrobial, antitumor activity, and enzyme inhibition. The design concept for the Ru complexes as multitargeted compounds consisting of a bioactive ligand and a ruthenium center is also emphasized.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Qi Sun, Yingsi Li, Hongdong Shi, Yi Wang, Jitian Zhang, Qianling Zhang
Summary: Lung cancer, with high mortality rate and incidence rate, poses a serious threat to human health. Ru(II/III) complexes have emerged as promising anticancer drug candidates due to their potential anticancer properties and selective cytotoxic activity.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Fabio Marchetti, Riccardo Pettinari, Federico Verdicchio, Alessia Tombesi, Stefania Scuri, Sonila Xhafa, Laura Olivieri, Claudio Pettinari, Duane Choquesillo-Lazarte, Amalia Garcia-Garcia, Antonio Rodriguez-Dieguez, Agustin Galindo
Summary: Hydrazones and their metal derivatives are important compounds in medicinal chemistry, and this study focused on the synthesis, characterization, and tautomerism of hydra-zone-pyrazolone ligands and their zinc complexes. The antibacterial activity of these compounds was also evaluated, and promising results were obtained.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Katia M. Oliveira, Joao Honorato, Felipe C. Demidoff, Mario S. Schultz, Chaquip D. Netto, Marcia R. Cominetti, Rodrigo S. Correa, Alzir A. Batista
Summary: The preparation and characterization of two new Ru(II)/diphosphine complexes containing Lapachol and Lawsone are described. These complexes exhibited high cytotoxicity against cancer cells, with complex (1) showing particular selectivity to triple-negative breast cancer cells. Mechanistic studies suggested that these complexes induce apoptosis in cancer cells through multiple pathways, making them promising candidates for cancer treatment.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Thallita Monteiro Teixeira, Isabela Gasparini Arraes, Davi Carvalho Abreu, Katia M. Oliveira, Rodrigo S. Correa, Alzir A. Batista, Thomas Braunbeck, Elisaangela de Paula Silveira Lacerda
Summary: The study reported the synthesis, characterization, and biological properties of two new ruthenium (II) complexes, which showed potential antitumor activity and high selectivity for human tumor cell lines.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Atousa Goudarzi, Mitra Ghassemzadeh, Maryam Saeidifar, Kioumars Aghapoor, Farshid Mohsenzadeh, Bernhard Neumueller
Summary: The synthesis of a new Pd(II) complex and its characterization were reported. The complex exhibited potent anticancer activity against MCF-7 breast cancer cells, and showed good antimicrobial activity against both Gram-positive and Gram-negative bacteria.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Denise Lovison, Dario Alessi, Lorenzo Allegri, Federica Baldan, Maurizio Ballico, Giuseppe Damante, Marilisa Galasso, Daniele Guardavaccaro, Silvia Ruggieri, Andrea Melchior, Daniele Veclani, Chiara Nardon, Walter Baratta
Summary: The paper describes a chiral ruthenium complex with high cytotoxic activity against various cell lines, particularly showing strong inhibition against the anaplastic thyroid cancer cell line 8505 C.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Leide Laura Figueiredo Maciel, Marina Barreto Silva, Rafaela Oliveira Moreira, Ana Paula Cardoso, Christiane Fernandes, Adolfo Horn Jr, Joao Carlos de Aquino Almeida, Milton Masahiko Kanashiro
Summary: This study investigated the antineoplastic activity of two platinum complexes containing alpha- and beta-naphthyl groups. The results showed that one of the platinum complexes exhibited higher cytotoxicity against all cancer cell lines tested and lower cytotoxicity against normal peripheral blood mononuclear cells. Further investigations revealed that this complex induced cell death by apoptosis and was associated with mitochondrial membrane depolarization, elevated levels of reactive oxygen species (ROS), and caspase activation.
Article
Chemistry, Inorganic & Nuclear
Dana Josa, David Aguila, Pere Fontova, Vanessa Soto-Cerrato, Piedad Herrera-Ramirez, Laia Rafols, Arnald Grabulosa, Patrick Gamez
Summary: Five metal-arene complexes and nine cyclometalated half-sandwich complexes were synthesized, characterized, and evaluated for cytotoxicity against human cancer cells. The complexes showed notable cytotoxic properties, particularly against lung adenocarcinoma cells. One of the complexes also exhibited significant toxic effects on other cell lines. Furthermore, the study identified a complex that impacted the cell cycle of lung adenocarcinoma cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Guang-Bin Jiang, Wen-Yao Zhang, Miao He, Yi-Ying Gu, Lan Bai, Yang-Jie Wang, Qiao-Yan Yi, Fan Du
Summary: Ruthenium-containing complexes show excellent cytotoxicity against HepG-2 cells, exhibit better antitumor activity than cisplatin, and have no obvious toxicity to normal cells. DNA binding results suggest interaction with DNA, and the complexes induce apoptosis through different pathways.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jose Manuel Veiga del Pino, Franco Scalambra, Cristina Bermejo-Casadesus, Anna Massaguer, Federico Garcia-Maroto, Antonio Romerosa
Summary: A water-soluble ruthenium complex was synthesized and characterized by various techniques. Its optical and biological properties were studied and compared with other ruthenium complexes. The complex showed high anticancer activity under visible light irradiation and exhibited no toxicity against red blood cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Amanda Alvim Negreti, Guilherme Alvaro Ferreira-Silva, Carolina Girotto Pressete, Rafael Fonseca, Caio C. Candido, Angelica E. Graminha, Antonio Carlos Doriguetto, Ester Siqueira Caixeta, Joao Adolfo Costa Hanemann, Angel Mauricio Castro-Gamero, Marilia I. F. Barbosa, Marta Miyazawa, Marisa Ionta
Summary: In this study, three ruthenium(ii) complexes containing cinnamic acid derivatives as ligands were synthesized and evaluated for their cytotoxic effects on melanoma cell lines. The results showed that one particular complex exhibited the most promising inhibitory activity, affecting cell cycle progression, inducing apoptosis, and inhibiting cell migration.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Thiago Ribeiro, Alisson Moraes E. Silva, Joao Honorato, Andre Luis Machado Viana, Henrique Faria, Andre Ruela, Antonio C. Doriguetto, Cecilia Maria Alves Oliveira, Felipe Terra Martins
Summary: This study addressed the hygroscopicity issue of adiphenine by preparing stable multicomponent crystal forms, designing two new salts for increased chemical stability, and comparing with adiphenine hydrochloride.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Helloana Azevedo-Barbosa, Guilherme Alvaro Ferreira-Silva, Bianca Pereira do Vale, Jamie Anthony Hawkes, Marisa Ionta, Diogo Teixeira Carvalho
Summary: A series of analogs of aryl sulfonamide hybrid compounds were synthesized and evaluated for their cytotoxic activity against MCF-7, MDA-MB-231, and Hs 578T breast cancer cell lines. Compound 10 showed promising antiproliferative activity against MDA-MB-231 cells.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Food Science & Technology
Nathalia da Silva Campos, Igor Lima de Paula, Italo Tuler Perrone, Luiz Fernando Cappa de Oliveira, Antonio Carlos Doriguetto, Alan Wolfschoon, Rodrigo Stephani
Summary: This study characterized the white dots in doce de leite using various analytical techniques. Results showed that the white dots were composed mainly of calcium citrate hexahydrate (CCH), amino acids, and a small amount of phosphates. The study also identified the formation mechanism of the white dots, suggesting the role of alpha(s1)-casein in heterogeneous nucleation and crystal growth.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ana Luisa A. Lage, Luisa A. Ribeiro, Antonio C. Doriguetto, Carlos B. Pinheiro, Wallace C. Nunes, Emerson F. Pedroso, Cynthia L. M. Pereira
Summary: This study presents the synthesis, crystal structure, and magnetic properties of a neutral hexacopper(II) complex, which exhibits a unique crystal structure with trinuclear units connected by oxamate bridges and shows both antiferromagnetic and ferromagnetic interactions through magnetic measurements.
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hsin-Yung Yen, Idlir Liko, Wanling Song, Parth Kapoor, Fernando Almeida, Joanna Toporowska, Karolina Gherbi, Jonathan T. S. Hopper, Steven J. Charlton, Argyris Politis, Mark S. P. Sansom, Ali Jazayeri, Carol Robinson
Summary: This study presents a mass spectrometry-based approach to investigate the biased signaling and allosteric modulation of the beta(1)-adrenergic receptor in response to different ligands. The researchers discovered that isoprenaline can act as a biased agonist and that endogenous zinc ions enhance the binding between the receptor and G(s) proteins.
Article
Chemistry, Inorganic & Nuclear
Henrique Vieira Reis Silva, Guilherme Alvaro Ferreira da Silva, Bruno Zavan, Rafael Pereira Machado, Joao Honorato de Araujo-Neto, Javier Alcides Ellena, Marisa Ionta, Marilia Imaculada Fraza, Antonio Carlos Doriguetto
Summary: A series of new ruthenium complexes were synthesized and characterized. These complexes interacted with DNA and human serum albumin and exhibited cytotoxicity against various cancer cells. One of the complexes showed higher toxicity against melanoma cells, inhibited clonogenic capacity, induced cell cycle arrest, and triggered apoptosis through the production of reactive oxygen species.
Article
Chemistry, Physical
Carlos Henrique de Moura Oliveira, Joao Honorato de Araujo Neto, Javier Alcides Elenna, Josidel Conceicao Oliver, Amanda Latercia Tranches Dias, Ivo Santana Caldas, Antonio Carlos Doriguetto
Summary: This study introduces two poly-iodide compounds, SMZ[I5].H2O and SDZ2[I4], which overcome the limitation of high oral dosage required for SMZ and SDZ drugs. The characteristics of SMZ[I5].H2O and SDZ2[I4] were systematically characterized using various techniques. In vitro experiments demonstrated the enhanced antimicrobial activity of SMZ[I5].H2O compared to unmodified SMZ.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Cristiane B. Goncalves, Rafael T. da Silva, Gustavo Dalenogare, Isabelle M. D. Gonzaga, Lucia H. Mascaro, Mateus M. Ferrer, Marcelo Assis, Elson Longo, Hugo B. de Carvalho, Antonio C. Doriguetto
Summary: This study presents a comprehensive analysis of morphology, microstructure, and optical properties of electrodeposited Cu2O thin films on SnO2:F substrates. The films exhibited stability, purity, and crystallinity, with various morphologies and growth orientations. These findings make a significant contribution to the exploration of multifunctional semiconductor materials for various advanced technologies.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Marilia I. F. Barbosa, Rodrigo S. Correa, Adriana P. M. Guedes, Alex M. Graca, Francyelli M. Andrade, Celisnolia M. Leite, Elisangela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antonio C. Doriguetto, Alzir A. Batista
Summary: Herein, we report on the synthesis and characterization of ruthenium compounds with different amino acids as ligands. The complexes were characterized using various techniques and the structures of two compounds were determined using X-ray diffraction. In vitro evaluation showed that these compounds exhibited cytotoxic activities against triple-negative breast cancer cells and inhibited their migration. Therefore, these compounds may be promising drug candidates for the treatment of triple-negative breast cancer.
Article
Biochemistry & Molecular Biology
Cintia A. Simosono, Rafaela M. R. da Silva, Nathalia R. De Campos, Marye Agnes R. Silva, Antonio C. Doriguetto, Leona S. Flores, Charlane C. Correa, Tatiana R. G. Simoes, Ana Karoline S. M. Valdo, Felipe T. Martins, Flavio Garcia, Guilherme P. Guedes, Breno R. L. Galvao, Juliana Cancino-Bernardi, Ricardo D. dos Reis, Humberto O. Stumpf, Danielle D. Justino, Paulo F. R. Ortega, Walace D. do Pim, Miguel Julve, Maria Vanda Marinho
Summary: In this article, the synthesis, crystal structure, and electronic properties of two compounds containing {Ni-2(II)} helical units were described. Both compounds exhibit reversible redox reactions mediated by OH- ions, but with different formal potentials reflecting changes in molecular orbital energy levels. One compound forms a 2D coordination network through connection with K+ counter cations, while the other compound forms a 2D array through supramolecular interactions with a [Ni(H2O)(6)](2+) complex cation.
Article
Chemistry, Multidisciplinary
Carla Miguel de Oliveira, Renato de Oliveira Horvath, Rafael Fonseca, Kris Simone Tranches Dias, Marisa Ionta, Claudio Viegas Jr
Summary: This study evaluated a series of N-benzyl-piperidinyl acylhydrazone hybrid derivatives for their cytotoxic activity on non-small cell lung cancer (A549) and hepatocellular carcinoma (HepG2) cells. PQM-75 (6i) exhibited the best antiproliferative activity against HepG2 cells, while PQM-88 (6k) showed the strongest activity against A549 cells. Furthermore, compound 6i demonstrated the ability to inhibit the clonogenic capacity of HepG2 cells and induce G2/M phase arrest.
REVISTA VIRTUAL DE QUIMICA
(2023)
Article
Engineering, Biomedical
Mayara Santos de Castro, Marta Miyazawa, Ester Siqueira Caixeta Nogueira, Jorge Kleber Chavasco, Gustavo Andrade Brancaglion, Claudio Daniel Cerdeira, Denismar Alves Nogueira, Marisa Ionta, Joao Adolfo Costa Hanemann, Maisa Ribeiro Pereira Lima Brigagao, Felipe Fornias Sperandio
Summary: This study evaluates the effects of PBM on human monocytes, revealing that PBM significantly increases intracellular and extracellular ROS production, enhances fungicidal capacity, and induces the expression of TNF-alpha and the production of NO in monocytes without impairing cell viability.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)