Article
Biochemistry & Molecular Biology
Roberto De Masi, Stefania Orlando, Vincenzo Toni, Maria Carmela Costa
Summary: We report a singular case of a 31-year-old woman who developed acute extrapyramidal syndrome and stable memory loss due to the incorrect use of Fluphenazine. MRI post-analysis showed a 6.5% loss in brain volume, indicating neurotoxic effects on cortical and sub-cortical grey matter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Shu-Hui Tao, Xue-Qun Ren, Li-Jun Zhang, Mei-Yan Liu
Summary: Statins have been proven to have antidepressant effects, but the antidepressant effects of ACEIs/ARB and aspirin are still controversial. Calcium channel blockers are associated with depression, but it is unclear whether this effect is beneficial or harmful. No association has been found with beta-blockers, diuretics, and nitrates.
CHINESE MEDICAL JOURNAL
(2021)
Review
Psychiatry
Guy Chouinard, Fiammetta Cosci, Virginie-Anne Chouinard, Larry Alphs
Summary: This article introduces the ESRS and ESRS-A as valid tools for measuring drug-induced movement disorders, highlighting their value in clinical research and clinics.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Clinical Neurology
Roberto Erro, Annamaria Landolfi, Giulia D'Agostino, Leonardo Pace, Marina Picillo, Massimo Scarano, Alberto Cuocolo, Sabina Pappata, Carmine Vitale, Maria Teresa Pellecchia, Palmiero Monteleone, Paolo Barone
Summary: Research suggests that up to 20% of patients with bipolar disorder and parkinsonism may have an underlying dopaminergic deficit, not solely due to exposure to drugs. This supports the idea that bipolar disorder may be a risk factor for developing neurodegenerative parkinsonism.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Anita Siller, Nadja T. Hofer, Giulia Tomagra, Nicole Burkert, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Joerg Striessnig
Summary: In Parkinson's disease, Cav2.3 R-type Ca2+ currents play a significant role in dopaminergic Substantia nigra neurons. The membrane-anchored beta 2 splice variants beta 2a and beta 2e are crucial for stabilizing Cav2.3 gating properties and enhancing Ca2+ currents. These findings were confirmed in mouse models.
Review
Biochemistry & Molecular Biology
Elena E. Vaiman, Natalia A. Shnayder, Maxim A. Novitsky, Vera S. Dobrodeeva, Polina S. Goncharova, Elena N. Bochanova, Margarita R. Sapronova, Tatiana E. Popova, Alexey A. Tappakhov, Regina F. Nasyrova
Summary: This review examines candidate genes encoding dopamine receptors as genetic predictors of AP-induced parkinsonism and AP-induced tardive dyskinesia in schizophrenia patients. While some positive associations were found, there is currently no definitive conclusion on the leading role of any specific SNVs/polymorphisms in the development of AIP and AITD.
Article
Pharmacology & Pharmacy
Fernando Facal, Begona Portela, Almudena Gil-Rodriguez, Francisco Barros, Olalla Maronas, Angel Carracedo
Summary: CYP2D6 analysis is required before prescribing pimozide to detect poor metabolizers and prevent adverse drug reactions. This study presents a case of a schizophrenia spectrum disorder patient who experienced severe side effects due to pimozide prescription. Genetic analysis revealed the patient's poor metabolizer status for CYP2D6, highlighting the importance of pharmacogenetic guidelines and training for psychiatry specialists when prescribing antipsychotic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ting Huang, Jingyi Zhou, Jianliu Wang
Summary: Intracellular calcium ions act as important regulators in cancer progression, with estrogen playing a role in inducing calcium increases and kinase cascades. Modulating calcium channels may offer a new approach for treating endometrial cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Liqiong Ding, Ping Jiang, Xinfeng Xu, Wanzhen Lu, Chan Yang, Lin Li, Pingzheng Zhou, Shuwen Liu
Summary: The study identified T-type calcium channel blockers as potential inhibitors of HSV-2 infection, while L-type calcium channel blockers showed no significant effect. Additionally, benidipine exerted antiviral effects by suppressing viral gene expression in the late stage of infection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Summary: This study investigates the effects of beta-blocker and calcium channel blocker antihypertensive drugs on maternal and foetal outcomes. The results suggest that beta-blocker use may lower birthweight, while calcium channel blocker use may reduce the risk of pre-eclampsia and eclampsia.
Article
Clinical Neurology
Brittany Richardson, Sabrina Swenson, John Hamilton, Ken Leonard, Foteini Delis, Mark Gold, Ken Blum, Panayotis K. Thanos
Summary: The study indicates that a chronic high-fat diet may affect GABA signaling in the rat cerebellum, and dietary changes can be used as an adjunct treatment for schizophrenia. The desynchronization between the prefrontal cortex and cerebellum is associated with major cognitive and motor dysfunctions commonly found in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Review
Endocrinology & Metabolism
Michael M. Gezalian, Luigi Mangiacotti, Padmesh Rajput, Nicklaus Sparrow, Konrad Schlick, Shouri Lahiri
Summary: Adrenoceptor and calcium channel modulating medications have cerebrovascular-specific effects related to the unique characteristics of cerebrovascular anatomy, which differ from their systemic effects. Future research should consider lesion location when selecting vasoactive medications, aiming to improve neurological outcomes in acute neurological and systemic disorders.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Editorial Material
Biochemistry & Molecular Biology
Weiqun Yu
Summary: Inhibition of bladder contraction with antimuscarinics is a common approach for treating bladder hyperactivity. The L-type voltage-gated calcium channel alpha(1C) (Cav1.2) plays a crucial role in bladder contractility. However, clinical trials using calcium channel blockers (CCBs) for treating bladder overactivity have been unsuccessful, contrary to expectations. Recent findings suggest that ketamine and nifedipine can function as Cav1.2 antagonists, and a Cav1.2 agonist can increase void volume and reduce voiding frequency. This perspective discusses the unsuccessful use of CCBs in urological trials and the potential of Cav1.2 agonists as novel therapies for bladder dysfunctions.