The Role of the Intestinal Microbiome in Type 1 Diabetes Pathogenesis

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

(2016) David K. Cole et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Viral infections in type 1 diabetes mellitus — why the β cells?

(2016) Anne Op de Beeck et al.   Nature Reviews Endocrinology

The role of the intestinal microbiota in type 1 diabetes mellitus

(2016) Mikael Knip et al.   Nature Reviews Endocrinology

The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

(2015) Aleksandar D. Kostic et al.   Cell Host & Microbe

Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   DIABETES

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

(2015) Aimon K. Alkanani et al.   DIABETES

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Novel players in coeliac disease pathogenesis: role of the gut microbiota

(2015) Elena F. Verdu et al.   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Aberrant gut microbiota composition at the onset of type 1 diabetes in young children

(2014) Marcus C. de Goffau et al.   DIABETOLOGIA

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes

(2014) Austin G. Davis-Richardson et al.   Frontiers in Microbiology

Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome

(2013) A. K. Alkanani et al.   DIABETES

Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade

(2013) Naoko Hara et al.   Innate Immunity

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Commensal bacteria at the interface of host metabolism and the immune system

(2013) Jonathan R Brestoff et al.   NATURE IMMUNOLOGY

Immune therapy in type 1 diabetes mellitus

(2013) Åke Lernmark et al.   Nature Reviews Endocrinology

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Prevention or acceleration of type 1 diabetes by viruses

(2012) Liana Ghazarian et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Maintenance of small intestinal and colonic tolerance by IL-10-producing regulatory T cell subsets

(2012) Sharon Veenbergen et al.   CURRENT OPINION IN IMMUNOLOGY

Fecal Microbiota Composition Differs Between Children With  -Cell Autoimmunity and Those Without

(2012) M. C. de Goffau et al.   DIABETES

Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice

(2012) Carles Ubeda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prevention of Virus-Induced Type 1 Diabetes with Antibiotic Therapy

(2012) N. Hara et al.   JOURNAL OF IMMUNOLOGY

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Innate immunity and its role in type 1 diabetes

(2011) Danny Zipris   Current Opinion in Endocrinology Diabetes and Obesity

Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetes

(2010) Pilar Londono et al.   CLINICAL IMMUNOLOGY

Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes

(2010) Sae Uno et al.   ENDOCRINE JOURNAL

Lactobacillus johnsonii N6.2 Mitigates the Development of Type 1 Diabetes in BB-DP Rats

(2010) Ricardo Valladares et al.   PLoS One

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes

(2009) Travis R. Wolter et al.   CLINICAL IMMUNOLOGY

Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms

(2009) Danny Zipris   CLINICAL IMMUNOLOGY

Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit: A Mechanism of Accelerated  -Cell Failure in Fulminant Type 1 Diabetes

(2009) S. Tanaka et al.   DIABETES

High-Fat Diet Determines the Composition of the Murine Gut Microbiome Independently of Obesity

(2009) Marie A. Hildebrandt et al.   GASTROENTEROLOGY

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

What are the consequences of the disappearing human microbiota?

(2009) Martin J. Blaser et al.   NATURE REVIEWS MICROBIOLOGY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Leaking gut in type 1 diabetes

(2008) Outi Vaarala   CURRENT OPINION IN GASTROENTEROLOGY

Commensal intestinal bacterial strains trigger ankylosing enthesopathy of the ankle in inbred B10.BR (H-2k) male mice

(2008) Z. Šinkorová et al.   HUMAN IMMUNOLOGY

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE