Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease

Vascular and Metabolic Factors in Alzheimer’s Disease and Related Dementias: Introduction

(2016) Costantino Iadecola   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neurovascular and Cognitive failure in Alzheimer’s Disease: Benefits of Cardiovascular Therapy

(2016) Edith Hamel et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Microvascular Dysfunction and Cognitive Impairment

(2016) T. Michael De Silva et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

(2016) Chelsea C. Hays et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?

(2016) Patricia M. Washington et al.   EXPERIMENTAL NEUROLOGY

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Neurorestoration after traumatic brain injury through angiotensin II receptor blockage

(2015) Sonia Villapol et al.   BRAIN

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations

(2015) Kenzo Koizumi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age

(2015) Olga Pletnikova et al.   Cognitive and Behavioral Neurology

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

(2015) Douglas G. Peters et al.   NEUROBIOLOGY OF DISEASE

The past and the future of Alzheimer's disease CSF biomarkers—a journey toward validated biochemical tests covering the whole spectrum of molecular events

(2015) Kaj Blennow et al.   Frontiers in Neuroscience

Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway

(2014) Tao Pang et al.   ACTA PHARMACOLOGICA SINICA

The role of inflammasome in Alzheimer's disease

(2014) Li Liu et al.   AGEING RESEARCH REVIEWS

Neuroprotective Effects of Angiotensin Receptor Blockers

(2014) Sonia Villapol et al.   AMERICAN JOURNAL OF HYPERTENSION

Peroxisome Proliferator-activated Receptor Gamma Concentrations in Newly Diagnosed Hypertension Patients and the Metabolic Effects of Olmesartan

(2014) Ömer Akyürek et al.   ARCHIVES OF MEDICAL RESEARCH

Impaired Renal Function and Biomarkers of Vascular Disease in Alzheimer’s Disease

(2014) Cassandra Richardson et al.   Current Alzheimer Research

Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease

(2014) Aisha Abeelen et al.   Current Alzheimer Research

Neuroprotective Properties of Peroxisome Proliferator-Activated Receptor Alpha (PPARα) and its Lipid Ligands

(2014) Marco Fidaleo et al.   CURRENT MEDICINAL CHEMISTRY

Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity

(2014) Arif U Hasan et al.   HYPERTENSION RESEARCH

Angiotensin II AT1 receptor blockade by telmisartan reduces impairment of spatial maze performance induced by both acute and chronic stress

(2014) Dominik Wincewicz et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

(2014) Brice Ongali et al.   NEUROBIOLOGY OF DISEASE

Role of PPARγin the Differentiation and Function of Neurons

(2014) Rodrigo A. Quintanilla et al.   PPAR Research

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

(2014) Juan M. Zolezzi et al.   Frontiers in Aging Neuroscience

2013 Alzheimer's disease facts and figures

(2013)   Alzheimers & Dementia

Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking

(2013) Young In Sohn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain

(2013) Stepan Aleshin et al.   BIOLOGICAL CHEMISTRY

Losartan protects liver against ischaemia/reperfusion injury through PPAR-γ activation and receptor for advanced glycation end-products down-regulation

(2013) Eun-Ji Koh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Do angiotensin receptor blockers prevent Alzheimerʼs disease?

(2013) Ihab Hajjar et al.   CURRENT OPINION IN CARDIOLOGY

Do Angiotensin Receptor Blockers Protect Against Alzheimer’s Disease?

(2013) Hitomi Kurinami et al.   DRUGS & AGING

Antihypertensive classes, cognitive decline and incidence of dementia

(2013) Natacha Levi Marpillat et al.   JOURNAL OF HYPERTENSION

Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial

(2013) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Cognitive Disorders and Dementia in CKD: The Neglected Kidney-Brain Axis

(2013) J.-M. Bugnicourt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

(2013) S. Yasar et al.   NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Telmisartan ameliorates glutamate-induced neurotoxicity: Roles of AT1 receptor blockade and PPARγ activation

(2013) Juan Wang et al.   NEUROPHARMACOLOGY

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

(2013) Mak Adam Daulatzai   NEUROTOXICITY RESEARCH

Adjusting the compass: new insights into the role of angiogenesis in Alzheimer’s disease

(2013) Wilfred A Jefferies et al.   Alzheimers Research & Therapy

Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus

(2012) Michael L. Johnson et al.   Alzheimers & Dementia

Do Angiotensin Receptor Blockers Really Hold Promise for the Improvement of Cognitive Functioning?

(2012) Chittaranjan Andrade et al.   ARCHIVES OF INTERNAL MEDICINE

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

(2012) Ihab Hajjar et al.   ARCHIVES OF NEUROLOGY

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

(2012) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

Angiotensin II AT1receptor blockers as treatments for inflammatory brain disorders

(2012) Juan M. Saavedra   CLINICAL SCIENCE

The intracrine renin–angiotensin system

(2012) Rajesh Kumar et al.   CLINICAL SCIENCE

Telmisartan Improves Insulin Resistance of Skeletal Muscle Through Peroxisome Proliferator-Activated Receptor-  Activation

(2012) L. Li et al.   DIABETES

Peroxisome Proliferator-Activated Receptor-γ Activation With Angiotensin II Type 1 Receptor Blockade Is Pivotal for the Prevention of Blood-Brain Barrier Impairment and Cognitive Decline in Type 2 Diabetic Mice

(2012) Li-Juan Min et al.   HYPERTENSION

Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan

(2012) Shin-ichiro Miura et al.   HYPERTENSION RESEARCH

Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways

(2012) Tao Pang et al.   Journal of Neuroinflammation

Candesartan, an Angiotensin II AT1-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice

(2012) Sonia Villapol et al.   NEUROPSYCHOPHARMACOLOGY

Whole-body distribution and radiation dosimetry of [11C]telmisartan as a biomarker for hepatic organic anion transporting polypeptide (OATP) 1B3

(2012) Keiji Shimizu et al.   NUCLEAR MEDICINE AND BIOLOGY

Brain penetration of telmisartan, a unique centrally acting angiotensin II type 1 receptor blocker, studied by PET in conscious rhesus macaques

(2012) Akihiro Noda et al.   NUCLEAR MEDICINE AND BIOLOGY

Role of central angiotensin receptors in scopolamine-induced impairment in memory, cerebral blood flow, and cholinergic function

(2012) Santoshkumar Tota et al.   PSYCHOPHARMACOLOGY

Valsartan restores inflammatory response by macrophages in adipose and hepatic tissues of LPS-infused mice

(2012) Misaki Iwashita et al.   Adipocyte

Mitochondrial oxidative stress mediates induction of autophagy and hypertrophy in angiotensin-II treated mouse hearts

(2011) Dao-Fu Dai et al.   Autophagy

Angiotensin II AT1 Receptor Blockers Ameliorate Inflammatory Stress: A Beneficial Effect for the Treatment of Brain Disorders

(2011) Juan M. Saavedra   CELLULAR AND MOLECULAR NEUROBIOLOGY

Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*

(2011) Ralph Timaru-Kast et al.   CRITICAL CARE MEDICINE

Impact and Therapeutic Potential of PPARs in Alzheimers Disease

(2011) Michael T. Heneka et al.   Current Neuropharmacology

Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats

(2011) M. Zhao et al.   DIABETES OBESITY & METABOLISM

Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease

(2011) Kazumasa Kume et al.   Geriatrics & Gerontology International

Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes

(2011) Tao Pang et al.   JOURNAL OF HYPERTENSION

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease

(2011) Etsuko Imabayashi et al.   Brain and Behavior

Angiotensin II Inhibits Insulin Binding to Endothelial Cells

(2011) Su-Jin Oh et al.   Diabetes & Metabolism Journal

Tissue Renin-Angiotensin-Aldosterone Systems: Targets for Pharmacological Therapy

(2010) Michael Bader   Annual Review of Pharmacology and Toxicology

Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia

(2010) Yukiko Kasahara et al.   BRAIN RESEARCH

Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen-glucose depletion

(2010) X Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of angiotensin II receptor subtype activation in cognitive function and ischaemic brain damage

(2010) Masatsugu Horiuchi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor κB and activator protein-1 activation

(2010) Michio Miyoshi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Losartan inhibits LPS-induced inflammatory signaling through a PPARγ-dependent mechanism in human THP-1 macrophages

(2010) Jianbo An et al.   HYPERTENSION RESEARCH

The Angiotensin II Type 1 Receptor Antagonist Olmesartan Preserves Cerebral Blood Flow and Cerebrovascular Reserve Capacity, and Accelerates Rehabilitative Outcomes in Hypertensive Patients with a History of Stroke

(2010) Shuji Matsumoto et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Methodological issues in the assessment of cognitive decline in ONTARGET and TRANSCEND

(2010) Augustine N Odili et al.   LANCET NEUROLOGY

Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies

(2010) Craig Anderson et al.   LANCET NEUROLOGY

Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

(2010) Julius Benicky et al.   NEUROPSYCHOPHARMACOLOGY

Angiotensin II induced cerebral microvascular inflammation and increased blood–brain barrier permeability via oxidative stress

(2010) M. Zhang et al.   NEUROSCIENCE

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Anti-Inflammatory Effects of Angiotensin Receptor Blockers in the Brain and the Periphery

(2009) Julius Benicky et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Strain vessel hypothesis: a viewpoint for linkage of albuminuria and cerebro-cardiovascular risk

(2009) Sadayoshi Ito et al.   HYPERTENSION RESEARCH

Angiotensin II Modulates BBB Permeability via Activation of the AT1 Receptor in Brain Endothelial Cells

(2009) Melissa A Fleegal-DeMotta et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes

(2009) Ignacio M Larrayoz et al.   JOURNAL OF HYPERTENSION

Seven decades of angiotensin (1939–2009)

(2009) Ranko Skrbic et al.   PEPTIDES

Candesartan improves memory decline in mice: Involvement of AT1 receptors in memory deficit induced by intracerebral streptozotocin

(2008) Santoshkumar Tota et al.   BEHAVIOURAL BRAIN RESEARCH

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of Telmisartan on Nitric Oxide–Asymmetrical Dimethylarginine System

(2008) Fortunato Scalera et al.   HYPERTENSION

The AT1 Receptor Antagonist, L-158,809, Prevents or Ameliorates Fractionated Whole-Brain Irradiation–Induced Cognitive Impairment

(2008) Mike E. Robbins et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study

(2008) Hans-Christoph Diener et al.   LANCET NEUROLOGY

Olfaction in patients with mild cognitive impairment and Alzheimer's disease

(2007) Jelena Djordjevic et al.   NEUROBIOLOGY OF AGING