The role of C5a in acute lung injury induced by highly pathogenic viral infections

Cross-species transmission and emergence of novel viruses from birds

(2015) Jasper Fuk-Woo Chan et al.   Current Opinion in Virology

Middle East respiratory syndrome coronavirus: Implications for health care facilities

(2014) Helena C. Maltezou et al.   AMERICAN JOURNAL OF INFECTION CONTROL

Complement System in Lung Disease

(2014) Pankita H. Pandya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Editorial Commentary: New Strategies for Treatment of Humans With Acute Lung Injury/Acute Respiratory Distress Syndrome

(2014) P. A. Ward   CLINICAL INFECTIOUS DISEASES

Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys

(2014) Shihui Sun et al.   CLINICAL INFECTIOUS DISEASES

Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps

(2014) Markus Bosmann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Clinical features and pathobiology of Ebolavirus infection

(2014) Aftab A. Ansari   JOURNAL OF AUTOIMMUNITY

Critical Role for the NLRP3 Inflammasome during Acute Lung Injury

(2014) J. J. Grailer et al.   JOURNAL OF IMMUNOLOGY

Dynamic behavior of lymphocyte subgroups correlates with clinical outcomes in human H7N9 infection

(2014) Yu Chen et al.   JOURNAL OF INFECTION

Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules

(2014) M. Husain et al.   JOURNAL OF VIROLOGY

Human H7N9 and H5N1 Influenza Viruses Differ in Induction of Cytokines and Tissue Tropism

(2014) V. A. Meliopoulos et al.   JOURNAL OF VIROLOGY

Severe H7N9 Infection Is Associated with Decreased Antigen-Presenting Capacity of CD14+ Cells

(2014) Hongyan Diao et al.   PLoS One

Profiles of Acute Cytokine and Antibody Responses in Patients Infected with Avian Influenza A H7N9

(2014) Rui Huang et al.   PLoS One

H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks

(2014) Simon Burggraaf et al.   VIRUS RESEARCH

Oxidative stress and free radicals in COPD – implications and relevance for treatment

(2014) Wolfgang Domej et al.   International Journal of Chronic Obstructive Pulmonary Disease

Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection

(2013) Qiang Liu et al.   ACTA PHARMACOLOGICA SINICA

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

(2013) Shihui Sun et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Clinical, Virological, and Histopathological Manifestations of Fatal Human Infections by Avian Influenza A(H7N9) Virus

(2013) Liang Yu et al.   CLINICAL INFECTIOUS DISEASES

Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury

(2013) Markus Bosmann et al.   FASEB JOURNAL

Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells

(2013) Wing-hong Kwan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities

(2013) Kelvin KW To et al.   LANCET INFECTIOUS DISEASES

Complement C5 Activation during Influenza A Infection in Mice Contributes to Neutrophil Recruitment and Lung Injury

(2013) Cristiana C. Garcia et al.   PLoS One

Viral Pathogens and Acute Lung Injury: Investigations Inspired by the SARS Epidemic and the 2009 H1N1 Influenza Pandemic

(2013) Michael Matthay et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

(2013) Jasper Fuk-Woo Chan et al.   TRENDS IN MICROBIOLOGY

Middle East Respiratory Syndrome-coronavirus infection: An overview

(2013) Jaffar A. Al-Tawfiq   Journal of Infection and Public Health

Impaired secretion of interferons by dendritic cells from aged subjects to influenza

(2012) Sangeetha Prakash et al.   AGE

Doxycycline treatment attenuates acute lung injury in mice infected with virulent influenza H3N2 virus: Involvement of matrix metalloproteinases

(2012) H.H. Ng et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

(2012) Yan Li et al.   MICROBES AND INFECTION

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza

(2011) Jan-Erik Berdal et al.   JOURNAL OF INFECTION

Distinct Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury Pathways in Two Different Nonhuman Primate Species

(2011) S. L. Smits et al.   JOURNAL OF VIROLOGY

Serum concentrations of complement anaphylatoxins and proinflammatory mediators in patients with 2009 H1N1 influenza

(2011) Rieko Ohta et al.   MICROBIOLOGY AND IMMUNOLOGY

Cofactor regulation of C5a chemotactic activity in physiological fluids. Requirement for the vitamin D binding protein, thrombospondin-1 and its receptors

(2011) Glenda Trujillo et al.   MOLECULAR IMMUNOLOGY

A Protective Role for Complement C3 Protein during Pandemic 2009 H1N1 and H5N1 Influenza A Virus Infection

(2011) Kevin B. O'Brien et al.   PLoS One

Complement and viral pathogenesis

(2011) Kristina A. Stoermer et al.   VIROLOGY

Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis

(2010) Liyan Wang et al.   CLINICAL IMMUNOLOGY

Mice Lacking Both TNF and IL‐1 Receptors Exhibit Reduced Lung Inflammation and Delay in Onset of Death following Infection with a Highly Virulent H5N1 Virus

(2010) Lucy A. Perrone et al.   JOURNAL OF INFECTIOUS DISEASES

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells

(2009) Lei Sun et al.   FASEB JOURNAL

The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma

(2009) Shuji Kanmura et al.   JOURNAL OF GASTROENTEROLOGY

Alternative Complement Pathway Deregulation Is Correlated with Dengue Severity

(2009) Eduardo J. M. Nascimento et al.   PLoS One

Locally Produced Complement Fragments C5a and C3a Provide Both Costimulatory and Survival Signals to Naive CD4+ T Cells

(2008) Michael G. Strainic et al.   IMMUNITY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Severe Acute Respiratory Syndrome (SARS) Coronavirus-Induced Lung Epithelial Cytokines Exacerbate SARS Pathogenesis by Modulating Intrinsic Functions of Monocyte-Derived Macrophages and Dendritic Cells

(2008) T. Yoshikawa et al.   JOURNAL OF VIROLOGY

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE