Hypoxia and Placental Development

Relationship between hypoxia and downstream pathogenic pathways in preeclampsia

(2017) Henri Augusto Korkes et al.   HYPERTENSION IN PREGNANCY

High altitude and pre-eclampsia: Adaptation or protection

(2017) Sarah I.Y. Ahmed et al.   MEDICAL HYPOTHESES

Hypersensitive termination of the hypoxic response by a disordered protein switch

(2017) Rebecca B. Berlow et al.   NATURE

Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation

(2017) Kevin P. Robb et al.   PLoS One

Maternal vascular responses to hypoxia in a rat model of intrauterine growth restriction

(2016) Mais M. Aljunaidy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development

(2016) Katharina Walentin et al.   BIOESSAYS

A Prolactin Family Paralog Regulates Placental Adaptations to a Physiological Stressor1

(2016) Pengli Bu et al.   BIOLOGY OF REPRODUCTION

Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4

(2016) Y. Yang et al.   BIOLOGY OF REPRODUCTION

Placental Hypoxia During Early Pregnancy Causes Maternal Hypertension and Placental Insufficiency in the Hypoxic Guinea Pig Model

(2016) L. P. Thompson et al.   BIOLOGY OF REPRODUCTION

Genetics of human origin and evolution: high-altitude adaptations

(2016) Abigail W Bigham   CURRENT OPINION IN GENETICS & DEVELOPMENT

Intact feto-placental growth in microRNA-210 deficient mice

(2016) Kamil Krawczynski et al.   PLACENTA

HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

(2016) Damayanti Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease

(2016) Mariko Horii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tipping the balance toward trophoblast development

(2016) Michael J. Soares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast

(2016) Cheryl Q.E. Lee et al.   Stem Cell Reports

Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity

(2015) Liliya M. Yamaleyeva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Embryo Mortality in Isg15−/− Mice Is Exacerbated by Environmental Stress1

(2015) Luiz E. Henkes et al.   BIOLOGY OF REPRODUCTION

Site-Specific Increases in Utero- and Fetoplacental Arterial Vascular Resistance in eNOS-Deficient Mice Due to Impaired Arterial Enlargement1

(2015) Monique Y. Rennie et al.   BIOLOGY OF REPRODUCTION

Preeclampsia: Syndrome or Disease?

(2015) Leslie Myatt et al.   CURRENT HYPERTENSION REPORTS

Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy

(2015) Hannah Matheson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hypoxia, AMPK activation and uterine artery vasoreactivity

(2015) K. L. Skeffington et al.   JOURNAL OF PHYSIOLOGY-LONDON

Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy

(2015) J. S. Higgins et al.   JOURNAL OF PHYSIOLOGY-LONDON

Meta-Analysis of Placental Transcriptome Data Identifies a Novel Molecular Pathway Related to Preeclampsia

(2015) Miranda van Uitert et al.   PLoS One

OVO-like 1 regulates progenitor cell fate in human trophoblast development

(2015) Stephen J. Renaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LIMK1 Regulates Human Trophoblast Invasion/Differentiation and Is Down-Regulated in Preeclampsia

(2014) Yan Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Cited2 is required in trophoblasts for correct placental capillary patterning

(2014) Julie L.M. Moreau et al.   DEVELOPMENTAL BIOLOGY

NDRG1 Deficiency Attenuates Fetal Growth and the Intrauterine Response to Hypoxic Injury

(2014) Jacob Larkin et al.   ENDOCRINOLOGY

Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy

(2014) Michael J. Soares et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia

(2014) Tiziana Cotechini et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Placental ischemia induces changes in gene expression in chorionic tissue

(2014) Eric M. George et al.   MAMMALIAN GENOME

Developmental differences in the expression of FGF receptors between human and mouse embryos

(2014) T. Kunath et al.   PLACENTA

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

(2014) R Michael Roberts et al.   REPRODUCTION

Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency

(2014) Yufen Xie et al.   Stem Cell Research

Hypoxia and HIFs in regulating the development of the hematopoietic system

(2013) Parisa Imanirad et al.   BLOOD CELLS MOLECULES AND DISEASES

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts

(2013) Ryan K.C. Yuen et al.   Epigenetics

Gestational Hypoxia Induces Preeclampsia-Like Symptoms via Heightened Endothelin-1 Signaling in Pregnant Rats

(2013) Jianjun Zhou et al.   HYPERTENSION

Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era

(2013) Nayia Petousi et al.   JOURNAL OF APPLIED PHYSIOLOGY

The structural biology of oestrogen metabolism

(2013) Mark P. Thomas et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Magnetic Resonance Imaging Detects Placental Hypoxia and Acidosis in Mouse Models of Perturbed Pregnancies

(2013) Gabriele Bobek et al.   PLoS One

ECM-Dependent HIF Induction Directs Trophoblast Stem Cell Fate via LIMK1-Mediated Cytoskeletal Rearrangement

(2013) Hwa J. Choi et al.   PLoS One

Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction

(2013) C. F. Rueda-Clausen et al.   Reproductive Sciences

HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo

(2013) Parisa Imanirad et al.   Stem Cell Research

Hypoxia and Trophoblast Differentiation: A Key Role for PPARγ

(2013) Veronique Tache et al.   STEM CELLS AND DEVELOPMENT

A model of preeclampsia in rats: the reduced uterine perfusion pressure (RUPP) model

(2012) Jing Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype

(2012) Laura C. Kusinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Connexin 31 (GJB3) Deficiency in Mouse Trophoblast Stem Cells Alters Giant Cell Differentiation and Leads to Loss of Oxygen Sensing1

(2012) Yvonne Koch et al.   BIOLOGY OF REPRODUCTION

Model systems for studying trophoblast differentiation from human pluripotent stem cells

(2012) Toshihiko Ezashi et al.   CELL AND TISSUE RESEARCH

NK cells, hypoxia and trophoblast cell differentiation

(2012) Damayanti Chakraborty et al.   CELL CYCLE

Trophoblasts Regulate the Placental Hematopoietic Niche through PDGF-B Signaling

(2012) Akanksha Chhabra et al.   DEVELOPMENTAL CELL

The updated biology of hypoxia-inducible factor

(2012) Samantha N Greer et al.   EMBO JOURNAL

Endothelial Nitric Oxide Synthase Deficiency Reduces Uterine Blood Flow, Spiral Artery Elongation, and Placental Oxygenation in Pregnant Mice

(2012) Shathiyah Kulandavelu et al.   HYPERTENSION

Endothelial NO Synthase Augments Fetoplacental Blood Flow, Placental Vascularization, and Fetal Growth in Mice

(2012) Shathiyah Kulandavelu et al.   HYPERTENSION

Rat placentation: An experimental model for investigating the hemochorial maternal-fetal interface

(2012) M.J. Soares et al.   PLACENTA

miR-210 Targets Iron-Sulfur Cluster Scaffold Homologue in Human Trophoblast Cell Lines

(2011) Deug-Chan Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage

(2011) Kazuo Asanoma et al.   DEVELOPMENTAL BIOLOGY

Remodeling of fetoplacental arteries in rats due to chronic hypoxia

(2011) A. Hvizdošová-Kleščová et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Peroxisome Proliferator-Activated Receptor-γ as a Potential Therapeutic Target in the Treatment of Preeclampsia

(2011) Fergus P. McCarthy et al.   HYPERTENSION

A Critical Role of Interleukin-10 in Modulating Hypoxia-Induced Preeclampsia-Like Disease in Mice

(2011) Zhongbin Lai et al.   HYPERTENSION

eNOS activation and NO function: Pregnancy adaptive programming of capacitative entry responses alters nitric oxide (NO) output in vascular endothelium–new insights into eNOS regulation through adaptive cell signaling

(2011) D S Boeldt et al.   JOURNAL OF ENDOCRINOLOGY

Chromosome-substituted rat strains provide insights into the genetics of placentation

(2011) Toshihiro Konno et al.   PHYSIOLOGICAL GENOMICS

Oxygen levels that optimize TSC culture are identified by maximizing growth rates and minimizing stress

(2011) S. Zhou et al.   PLACENTA

Review: Oxygen and trophoblast biology – A source of controversy

(2011) M.G. Tuuli et al.   PLACENTA

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

(2011) D. Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Humans at high altitude: Hypoxia and fetal growth

(2011) Lorna G. Moore et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

(2010) Ivo Brosens et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Effects of Hypoxia-Inducible Factor-1α Overexpression in Pregnant Mice

(2010) Reshef Tal et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-10: A Multi-Faceted Agent of Pregnancy

(2010) Jessica E. Thaxton et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The first trimester human placenta is a site for terminal maturation of primitive erythroid cells

(2010) B. Van Handel et al.   BLOOD

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Natural killer cell-triggered vascular transformation: maternal care before birth?

(2010) Jianhong Zhang et al.   Cellular & Molecular Immunology

Subfertility Linked to Combined Luteal Insufficiency and Uterine Progesterone Resistance

(2010) Toshihiro Konno et al.   ENDOCRINOLOGY

Hematopoietic stem cell development in the placenta

(2010) Christos Gekas et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

COMMD1 disrupts HIF-1α/β dimerization and inhibits human tumor cell invasion

(2010) Bart van de Sluis et al.   JOURNAL OF CLINICAL INVESTIGATION

Negative Feedback Regulation of NF- B Action by CITED2 in the Nucleus

(2010) X. Lou et al.   JOURNAL OF IMMUNOLOGY

Spontaneous Pregnancy Loss Mediated by Abnormal Maternal Inflammation in Rats Is Linked to Deficient Uteroplacental Perfusion

(2010) S. J. Renaud et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Fetal–Placental Hypoxia Does Not Result from Failure of Spiral Arterial Modification in Mice

(2010) E. Leno-Durán et al.   PLACENTA

Abnormalities in Oxygen Sensing Define Early and Late Onset Preeclampsia as Distinct Pathologies

(2010) Alessandro Rolfo et al.   PLoS One

Pre-eclampsia: connecting angiogenic and metabolic pathways

(2010) Vivek Shenoy et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Placenta as a source of hematopoietic stem cells

(2010) Elaine Dzierzak et al.   TRENDS IN MOLECULAR MEDICINE

Magnetic resonance imaging of hypoxic injury to the murine placenta

(2009) Tracy M. Tomlinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Defects in embryonic development of EGLN1/PHD2 knockdown transgenic mice are associated with induction of Igfbp in the placenta

(2009) Terence R.S. Ozolinš et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Placenta Is a Potent Hematopoietic Niche Containing Hematopoietic Stem and Progenitor Cells throughout Development

(2009) Catherine Robin et al.   Cell Stem Cell

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Up-Regulation of α5-Integrin by E-Cadherin Loss in Hypoxia and Its Key Role in the Migration of Extravillous Trophoblast Cells during Early Implantation

(2009) Emi Arimoto-Ishida et al.   ENDOCRINOLOGY

Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy

(2009) K. G. Pringle et al.   HUMAN REPRODUCTION UPDATE

Interleukin-10: new perspectives on an old cytokine

(2009) David M. Mosser et al.   IMMUNOLOGICAL REVIEWS

The influence of the intrauterine environment on human placental development

(2009) Graham J. Burton et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Oxygen as modulator of trophoblast invasion

(2009) Berthold Huppertz et al.   JOURNAL OF ANATOMY

Impact of Pregnancy at High Altitude on Placental Morphology in Non-native Women With and Without Preeclampsia

(2009) M.C. Tissot van Patot et al.   PLACENTA

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1α via HSP90/70

(2009) Bart van de Sluis et al.   PLoS One

A New Role for the Human Placenta as a Hematopoietic Site Throughout Gestation

(2009) Alicia Barcena et al.   Reproductive Sciences

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the rat

(2008) Vít Jakoubek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Evolution, Regulation, and Function of Placenta-Specific Genes

(2008) Saara M. Rawn et al.   Annual Review of Cell and Developmental Biology

Hypoxia-Inducible Factor 1alpha (HIF1A) Mediates Distinct Steps of Rat Trophoblast Differentiation in Gradient Oxygen1

(2008) Amy D. Gultice et al.   BIOLOGY OF REPRODUCTION

The Emergence of Hematopoietic Stem Cells Is Initiated in the Placental Vasculature in the Absence of Circulation

(2008) Katrin E. Rhodes et al.   Cell Stem Cell

Maternal hypoxia activates endovascular trophoblast cell invasion

(2008) Gracy X. Rosario et al.   DEVELOPMENTAL BIOLOGY

Hypertension Produced by Placental Ischemia in Pregnant Rats Is Associated With Increased Soluble Endoglin Expression

(2008) Jeffrey S. Gilbert et al.   HYPERTENSION

Oxygen, the Janus gas; its effects on human placental development and function

(2008) Graham J. Burton   JOURNAL OF ANATOMY

Decidual Cells Produce a Heparin-binding Prolactin Family Cytokine with Putative Intrauterine Regulatory Actions

(2008) S. M. Khorshed Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

(2008) Keizo Kanasaki et al.   NATURE

Proteasomal Activity in Placentas from Women with Preeclampsia and Intrauterine Growth Restriction: Implications for Expression of HIF-α Proteins

(2008) A. Rajakumar et al.   PLACENTA