Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

(2019) Maki Miyamoto et al.   XENOBIOTICA

A long-term culture system based on a collagen vitrigel membrane chamber that supports liver-specific functions of hepatocytes isolated from mice with humanized livers

(2018) Ryuji Watari et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Frequency and Pathophysiology of Acute Liver Failure in Ornithine Transcarbamylase Deficiency (OTCD)

(2016) Alexander Laemmle et al.   PLoS One

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice

(2015) Yuji Ishida et al.   AMERICAN JOURNAL OF PATHOLOGY

Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

(2015) Seigo Sanoh et al.   XENOBIOTICA

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

(2015) Chise Tateno et al.   PLoS One

Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

(2014) Tomoya Yamada et al.   TOXICOLOGICAL SCIENCES

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

(2013) Masakazu Kakuni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

(2012) Chise Tateno et al.   LABORATORY INVESTIGATION

Differential Effect of Troglitazone on the Human Bile Acid Transporters, MRP2 and BSEP, in the PXB Hepatic Chimeric Mouse

(2012) John R. Foster et al.   TOXICOLOGIC PATHOLOGY

Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

(2012) Masakazu Kakuni et al.   TOXICOLOGY LETTERS

In vitro models for liver toxicity testing

(2012) Valerie Y. Soldatow et al.   Toxicology Research

The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional

(2011) Masami Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes

(2011) Mariya A. Smetanina et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of cell spot sizes on micropatterned cultures of rat hepatocytes

(2010) Kohji Nakazawa et al.   BIOCHEMICAL ENGINEERING JOURNAL

In Vitro Evaluation of Potential Hepatotoxicity Induced by Drugs

(2010) M.J. Gomez-Lechon et al.   CURRENT PHARMACEUTICAL DESIGN

In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

(2010) Chihiro Yamasaki et al.   Drug Metabolism and Pharmacokinetics

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

(2010) X. Yang et al.   GENOME RESEARCH

Liver X receptor α and farnesoid X receptor are major transcriptional regulators of OATP1B1

(2010) Henriette E. Meyer zu Schwabedissen et al.   HEPATOLOGY

CCAAT/Enhancer-binding Protein α (C/EBPα) and Hepatocyte Nuclear Factor 4α (HNF4α) Synergistically Cooperate with Constitutive Androstane Receptor to Transactivate the Human Cytochrome P450 2B6 (CYP2B6) Gene

(2010) Marta Benet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic OATP1B Transporters and Nuclear Receptors PXR and CAR: Interplay, Regulation of Drug Disposition Genes, and Single Nucleotide Polymorphisms

(2009) Henriette E. Meyer zu Schwabedissen et al.   MOLECULAR PHARMACEUTICS

Establishment of an infectious genotype 1b hepatitis C virus clone in human hepatocyte chimeric mice

(2008) T. Kimura et al.   JOURNAL OF GENERAL VIROLOGY