Human Hepatocytes Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogen Sodium Phenobarbital in an In Vivo Study Using a Chimeric Mouse with Humanized Liver

Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors

(2014) Raphaëlle Luisier et al.   TOXICOLOGICAL SCIENCES

Phenobarbital-Mediated Tumor Promotion in Transgenic Mice with Humanized CAR and PXR

(2014) Albert Braeuning et al.   TOXICOLOGICAL SCIENCES

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

(2013) Clifford R. Elcombe et al.   CRITICAL REVIEWS IN TOXICOLOGY

A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer

(2013) Carlo La Vecchia et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies

(2013) John R. Foster et al.   XENOBIOTICA

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

(2013) Shigeyuki Kitamura et al.   XENOBIOTICA

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

(2012) Chise Tateno et al.   LABORATORY INVESTIGATION

Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver

(2011) Chise Tateno et al.   ENDOCRINOLOGY

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

(2011) Jianmin Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR

(2010) Antonia H. Tolson et al.   ADVANCED DRUG DELIVERY REVIEWS

Nuclear Receptor CAR Represses TNFα-Induced Cell Death by Interacting with the Anti-Apoptotic GADD45B

(2010) Yukio Yamamoto et al.   PLoS One

Evaluation of Possible Carcinogenic Risk to Humans Based on Liver Tumors in Rodent Assays

(2010) Samuel M. Cohen   TOXICOLOGIC PATHOLOGY

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

(2010) Jillian Ross et al.   TOXICOLOGICAL SCIENCES

Chemical Carcinogenesis

(2010) S. M. Cohen et al.   TOXICOLOGICAL SCIENCES

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

(2009) Huw B. Jones et al.   FOOD AND CHEMICAL TOXICOLOGY

Epidemiologic evaluation of pharmaceuticals with limited evidence of carcinogenicity

(2009) Gary D. Friedman et al.   INTERNATIONAL JOURNAL OF CANCER

Mode of Action Analysis for the Synthetic Pyrethroid Metofluthrin-Induced Rat Liver Tumors: Evidence for Hepatic CYP2B Induction and Hepatocyte Proliferation

(2009) Yoshihito Deguchi et al.   TOXICOLOGICAL SCIENCES

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

(2009) Yukihiro Hirose et al.   TOXICOLOGY

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

(2009) B. G. Lake   XENOBIOTICA

Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

(2008) Salvatore Papa et al.   JOURNAL OF CLINICAL INVESTIGATION