Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

(2013) Seigo Sanoh et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

(2013) Shigeyuki Kitamura et al.   XENOBIOTICA

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

(2012) Franco Lombardo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 1: Volume of Distribution at Steady State

(2012) Franco Lombardo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

(2012) Chise Tateno et al.   LABORATORY INVESTIGATION

Prediction of Human Oral Plasma Concentration-Time Profiles Using Preclinical Data

(2011) An Van den Bergh et al.   CLINICAL PHARMACOKINETICS

Human Pharmacokinetic Prediction of UDP-Glucuronosyltransferase Substrates with an Animal Scale-Up Approach

(2011) T. Deguchi et al.   DRUG METABOLISM AND DISPOSITION

Prediction of Human Plasma Concentration-time Profiles of Monoclonal Antibodies from Monkey Data by a Species-invariant Time Method

(2011) Masataka Oitate et al.   Drug Metabolism and Pharmacokinetics

Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine

(2011) Cheng Li et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs

(2011) Yeamin Huh et al.   XENOBIOTICA

Hepatic Hyperplasia Associated with Discordant Xenogeneic Parenchymal-Nonparenchymal Interactions in Human Hepatocyte-Repopulated Mice

(2010) Rie Utoh et al.   AMERICAN JOURNAL OF PATHOLOGY

Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage

(2009) Shin-ichi Satoh et al.   BRAIN RESEARCH BULLETIN

Comparative Study of Increased Plasma Quinidine Concentration in Rats with Glyceroland Cisplatin-induced Acute Renal Failure

(2009) Yuki Izuwa et al.   Drug Metabolism and Pharmacokinetics

Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches

(2009) Natilie A. Hosea et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

(2008) S. Kitamura et al.   DRUG METABOLISM AND DISPOSITION

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION