Baicalin Ameliorates Cognitive Impairment and Protects Microglia from LPS-Induced Neuroinflammation via the SIRT1/HMGB1 Pathway

Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice

(2020) Xiaole Tang et al.   Oxidative Medicine and Cellular Longevity

Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo

(2019) Li Liu et al.   MOLECULES

Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy

(2019) Jiang Fang et al.   Frontiers in Neuroscience

Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats

(2019) Haiyang Yu et al.   PHYTOTHERAPY RESEARCH

AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling

(2019) Wen-Jun Yan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

(2019) Xin Jin et al.   CNS Neuroscience & Therapeutics

Neuroinflammation and Perioperative Neurocognitive Disorders

(2019) Saraswathi Subramaniyan et al.   ANESTHESIA AND ANALGESIA

Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

(2019) Li-Ting Guo et al.   Journal of Neuroinflammation

Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac/LIMK/cofilin pathway

(2019) Ye Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

(2019) Juan Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases

(2019) Yuqing Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264.7 cells and endotoxemic mice

(2018) Young Min Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

(2018) Teresa Ravizza et al.   BRAIN BEHAVIOR AND IMMUNITY

Sevoflurane preconditioning ameliorates lipopolysaccharide-induced cognitive impairment in mice

(2018) Maiko Satomoto et al.   EXPERIMENTAL ANIMALS

Omega-3 polyunsaturated fatty acid attenuates the inflammatory response by modulating microglia polarization through SIRT1-mediated deacetylation of the HMGB1/NF-κB pathway following experimental traumatic brain injury

(2018) Xiangrong Chen et al.   Journal of Neuroinflammation

SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy

(2018) Sang-Won Min et al.   JOURNAL OF NEUROSCIENCE

Isoflurane‑induced postoperative cognitive dysfunction is mediated by hypoxia‑inducible factor‑1α‑dependent neuroinflammation in aged rats

(2018) Yiyun Cao et al.   Molecular Medicine Reports

Sirt1 mediates improvement of isoflurane-induced memory impairment following hyperbaric oxygen preconditioning in middle-aged mice

(2018) Hu Hong-qiang et al.   PHYSIOLOGY & BEHAVIOR

Astragaloside IV protects blood-brain barrier integrity from LPS-induced disruption via activating Nrf2 antioxidant signaling pathway in mice

(2018) Hongli Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner

(2018) Jung Seok Hwang et al.   PeerJ

Resveratrol-loaded nanoemulsion prevents cognitive decline after abdominal surgery in aged rats

(2018) Fabricio M. Locatelli et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway

(2018) Shangwen Pan et al.   Frontiers in Cellular Neuroscience

Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018

(2018) L. Evered et al.   ANESTHESIOLOGY

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

(2017) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

(2017) Shanshan Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

(2017) Xiangrong Chen et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats

(2017) Rui Wang et al.   NEUROSCIENCE

Salidroside Inhibits HMGB1 Acetylation and Release through Upregulation of SirT1 during Inflammation

(2017) Zhilin Qi et al.   Oxidative Medicine and Cellular Longevity

Baicalin Attenuates Subarachnoid Hemorrhagic Brain Injury by Modulating Blood-Brain Barrier Disruption, Inflammation, and Oxidative Damage in Mice

(2017) Xianqing Shi et al.   Oxidative Medicine and Cellular Longevity

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats

(2016) Min Hui Kan et al.   Frontiers in Aging Neuroscience

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats

(2016) Niccolò Terrando et al.   Frontiers in Immunology

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

High-mobility group box 1 is a novel deacetylation target of Sirtuin1

(2015) May M. Rabadi et al.   KIDNEY INTERNATIONAL

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning

(2014) Iris B. Hovens et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats

(2014) Hui Qun Fu et al.   PLoS One

Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1

(2014) J S Hwang et al.   Cell Death & Disease

Glycyrrhizin Alleviates Neuroinflammation and Memory Deficit Induced by Systemic Lipopolysaccharide Treatment in Mice

(2013) Jeong-Ho Song et al.   MOLECULES

Promising Therapeutics with Natural Bioactive Compounds for Improving Learning and Memory — A Review of Randomized Trials

(2012) Hemant Kumar et al.   MOLECULES

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Neuroprotective effect of baicalin on compression spinal cord injury in rats

(2010) Yang Cao et al.   BRAIN RESEARCH

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Long-term Consequences of Postoperative Cognitive Dysfunction

(2009) Jacob Steinmetz et al.   ANESTHESIOLOGY

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE