Baicalin reverse depressive-like behaviors through regulation SIRT1-NF-kB signaling pathway in olfactory bulbectomized rats

Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression

(2018) Wei Zou et al.   PLoS One

Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

(2018) Asem Alageel et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice

(2018) K. Nishida et al.   Bone & Joint Research

Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression

(2018) Chen-Yi-Yu Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation

(2017) Carmine M. Pariante   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The absence of 5-HT4 receptors modulates depression- and anxiety-like responses and influences the response of fluoxetine in olfactory bulbectomised mice: Adaptive changes in hippocampal neuroplasticity markers and 5-HT1A autoreceptor

(2016) J. Amigó et al.   NEUROPHARMACOLOGY

Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression

(2016) Kuo Zhang et al.   Scientific Reports

Dynamics of the HPA axis and inflammatory cytokines: Insights from mathematical modeling

(2015) Hamed Malek et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Sparse whole-genome sequencing identifies two loci for major depressive disorder

(2015) Na Cai et al.   NATURE

Baicalin Reverses Depressive-Like Behaviours and Regulates Apoptotic Signalling Induced by Olfactory Bulbectomy

(2015) Hai-Yang Yu et al.   PHYTOTHERAPY RESEARCH

Baicalin reverse AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats

(2014) Hai-Yang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterisation of the antidepressant properties of nitric oxide synthase inhibitors in the olfactory bulbectomised rat model of depression

(2014) Valentina Gigliucci et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Chronic resveratrol treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with mononeuropathy: Involvement of serotonergic system

(2014) Xin Zhao et al.   NEUROPHARMACOLOGY

Etazolate, a phosphodiesterase-4 enzyme inhibitor produces antidepressant-like effects by blocking the behavioral, biochemical, neurobiological deficits and histological abnormalities in hippocampus region caused by olfactory bulbectomy

(2014) Ankur Jindal et al.   PSYCHOPHARMACOLOGY

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Baicalin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage

(2013) Qing-Bo Zhou et al.   INFLAMMATION

Sirtuin deacylases: a molecular link between metabolism and immunity

(2013) Nicolas Preyat et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Brain Activation of SIRT1: Role in Neuropathology

(2013) Alanna Fernandes Paraíso et al.   MOLECULAR NEUROBIOLOGY

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

Negative regulation of inflammation by SIRT1

(2012) Jun Xie et al.   PHARMACOLOGICAL RESEARCH

Baicalin Downregulates Porphyromonas gingivalis Lipopolysaccharide-Upregulated IL-6 and IL-8 Expression in Human Oral Keratinocytes by Negative Regulation of TLR Signaling

(2012) Wei Luo et al.   PLoS One

Chronic treatment with baicalin prevents the chronic mild stress-induced depressive-like behavior: Involving the inhibition of cyclooxygenase-2 in rat brain

(2012) Yu-Cheng Li et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress

(2012) Milena Girotti et al.   PSYCHONEUROENDOCRINOLOGY

Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells

(2011) Fei Yin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Neuroprotective effect of baicalin on compression spinal cord injury in rats

(2010) Yang Cao et al.   BRAIN RESEARCH

Baicalin attenuates inflammation by inhibiting NF-κB activation in cigarette smoke induced inflammatory models

(2010) Zeng Lixuan et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS