Central Nervous System Targets: Inhibitory Interneurons in the Spinal Cord

Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

(2020) Cedric Peirs et al.   JOURNAL OF NEURAL TRANSMISSION

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

(2019) Kieran A. Boyle et al.   Cell Reports

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Characterization of Superficial Dorsal Horn Neurons from “Tamamaki” Mice and Stability of their GAD67-EGFP Phenotype in Defined-Medium Organotypic Culture

(2018) Paul A. Boakye et al.   NEUROSCIENCE

Etiology and Pharmacology of Neuropathic Pain

(2018) Sascha R. A. Alles et al.   PHARMACOLOGICAL REVIEWS

Morphological and Physiological Plasticity of Spinal Lamina II GABA Neurons Is Induced by Sciatic Nerve Chronic Constriction Injury in Mice

(2018) Hongmei Zhang et al.   Frontiers in Cellular Neuroscience

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings

(2018) Francie Moehring et al.   NEURON

Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord

(2018) Maria Gutierrez-Mecinas et al.   NEUROSCIENCE

GABAB receptors-mediated tonic inhibition of glutamate release from Aβ fibers in rat laminae III/IV of the spinal cord dorsal horn

(2017) Chiara Salio et al.   Molecular Pain

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn

(2017) Andrew J Todd   Molecular Pain

A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord

(2017) Kieran A. Boyle et al.   NEUROSCIENCE

Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn

(2017) Max Larsson   NEUROSCIENCE LETTERS

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

(2017) Keisuke Koga et al.   Scientific Reports

Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-positive neuron excitability in the spinal cord dorsal horn

(2016) K.M. Smith et al.   NEUROSCIENCE

A combined electrophysiological and morphological study of neuropeptide Y–expressing inhibitory interneurons in the spinal dorsal horn of the mouse

(2016) Noboru Iwagaki et al.   PAIN

Neural circuits for pain: Recent advances and current views

(2016) C. Peirs et al.   SCIENCE

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

(2016) Kristopher T. Kahle et al.   Science Signaling

The change of HCN1/HCN2 mRNA expression in peripheral nerve after chronic constriction injury induced neuropathy followed by pulsed electromagnetic field therapy

(2016) Hui Liu et al.   Oncotarget

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

(2016) Kristopher T. Kahle et al.   Science Signaling

Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets

(2015) R. P. Ganley et al.   JOURNAL OF NEUROSCIENCE

Functional heterogeneity of calretinin-expressing neurons in the mouse superficial dorsal horn: implications for spinal pain processing

(2015) K. M. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors

(2014) L.-E. Lorenzo et al.   JOURNAL OF NEUROSCIENCE

A Putative Relay Circuit Providing Low-Threshold Mechanoreceptive Input to Lamina I Projection Neurons via Vertical Cells in Lamina II of the Rat Dorsal Horn

(2014) Toshiharu Yasaka et al.   Molecular Pain

Spatial and Temporal Pattern of Changes in the Number of GAD65-Immunoreactive Inhibitory Terminals in the Rat Superficial Dorsal Horn following Peripheral Nerve Injury

(2014) Louis-Etienne Lorenzo et al.   Molecular Pain

Presynaptic inhibition of spinal sensory feedback ensures smooth movement

(2014) Andrew J. P. Fink et al.   NATURE

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Prevention of NKCC1 phosphorylation avoids downregulation of KCC2 in central sensory pathways and reduces neuropathic pain after peripheral nerve injury

(2014) Laura Mòdol et al.   PAIN

Pre- and postsynaptic inhibitory control in the spinal cord dorsal horn

(2013) Rita Bardoni et al.   Annals of the New York Academy of Sciences

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn

(2013) Pradeep Punnakkal et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus

(2013) D.I. Hughes et al.   NEUROSCIENCE

Impaired Excitatory Drive to Spinal Gabaergic Neurons of Neuropathic Mice

(2013) Jörg Leitner et al.   PLoS One

A Quantitative Study of Inhibitory Interneurons in Laminae I-III of the Mouse Spinal Dorsal Horn

(2013) Erika Polgár et al.   PLoS One

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective distribution of GABAAreceptor subtypes in mouse spinal dorsal horn neurons and primary afferents

(2012) Jolly Paul et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn

(2012) D. I. Hughes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Pre- and post-synaptic switches of GABA actions associated with Cl− homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain

(2012) B. Wei et al.   NEUROSCIENCE

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

(2012) Hanns Ulrich Zeilhofer et al.   PHYSIOLOGICAL REVIEWS

HCN channelopathies: pathophysiology in genetic epilepsy and therapeutic implications

(2011) Christopher A Reid et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycinergic and GABAergic tonic inhibition fine tune inhibitory control in regionally distinct subpopulations of dorsal horn neurons

(2010) Tomonori Takazawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

Overcoming obstacles to developing new analgesics

(2010) Clifford J Woolf   NATURE MEDICINE

HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease

(2010) C Savio Chan et al.   NATURE NEUROSCIENCE

Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes

(2010) C. Maier et al.   PAIN

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach

(2010) Toshiharu Yasaka et al.   PAIN

Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling

(2009) Matilde Cordero-Erausquin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Glycine Inhibitory Dysfunction Induces a Selectively Dynamic, Morphine-Resistant, and Neurokinin 1 Receptor- Independent Mechanical Allodynia

(2009) L. S. Miraucourt et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Different Forms of Glycine- and GABAA-Receptor Mediated Inhibitory Synaptic Transmission in Mouse Superficial and Deep Dorsal Horn Neurons

(2009) Wayne B Anderson et al.   Molecular Pain

Models and Mechanisms of Hyperalgesia and Allodynia

(2009) Jürgen Sandkühler   PHYSIOLOGICAL REVIEWS

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Dissection of Neural Circuits

(2008) Liqun Luo et al.   NEURON

GABAA receptors: Subtypes provide diversity of function and pharmacology

(2008) Richard W. Olsen et al.   NEUROPHARMACOLOGY

Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABAA receptors from synapses in laminae I–II of the ipsilateral spinal dorsal horn

(2008) E. Polgár et al.   NEUROSCIENCE

Morphophysiologic properties of islet cells in substantia gelatinosa of the rat spinal cord

(2008) Igor Melnick   NEUROSCIENCE LETTERS