Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia

PKCγ interneurons, a gateway to pathological pain in the dorsal horn

(2020) Alain Artola et al.   JOURNAL OF NEURAL TRANSMISSION

Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals

(2019) Gioele W. Albisetti et al.   JOURNAL OF NEUROSCIENCE

Expression of cholecystokinin by neurons in mouse spinal dorsal horn

(2019) Maria Gutierrez-Mecinas et al.   JOURNAL OF COMPARATIVE NEUROLOGY

How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch

(2019) Martina Pagani et al.   NEURON

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function

(2019) Graziana Gatto et al.   CURRENT OPINION IN NEUROBIOLOGY

Trigeminal Aδ- and C-afferent supply of lamina I neurons in the trigeminocervical complex

(2019) Liliana L. Luz et al.   PAIN

Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn

(2019) Tyler S. Nelson et al.   Scientific Reports

Defining a Spinal Microcircuit that Gates Myelinated Afferent Input: Implications for Tactile Allodynia

(2019) Kieran A. Boyle et al.   Cell Reports

Expression of Neuropeptide FF Defines a Population of Excitatory Interneurons in the Superficial Dorsal Horn of the Mouse Spinal Cord that Respond to Noxious and Pruritic Stimuli

(2019) Maria Gutierrez-Mecinas et al.   NEUROSCIENCE

Recruitment of Spinoparabrachial Neurons by Dorsal Horn Calretinin Neurons

(2019) Hugues Petitjean et al.   Cell Reports

Reviewing the case for compromised spinal inhibition in neuropathic pain

(2019) M. A. Gradwell et al.   JOURNAL OF NEURAL TRANSMISSION

The emergence of animal models of chronic pain and logistical and methodological issues concerning their use

(2019) Terence J. Coderre et al.   JOURNAL OF NEURAL TRANSMISSION

Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements

(2019) Sónia Paixão et al.   NEURON

Spinal Circuits for Touch, Pain, and Itch

(2018) Stephanie C. Koch et al.   Annual Review of Physiology

Substance P-expressing excitatory interneurons in the mouse superficial dorsal horn provide a propriospinal input to the lateral spinal nucleus

(2018) Maria Gutierrez-Mecinas et al.   Brain Structure & Function

Animal Models of Chronic Migraine

(2018) Tse-Ming Chou et al.   Current Pain and Headache Reports

Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons

(2018) Arjun Balachandar et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types

(2018) Martin Häring et al.   NATURE NEUROSCIENCE

Circuit dissection of the role of somatostatin in itch and pain

(2018) Jing Huang et al.   NATURE NEUROSCIENCE

Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits

(2018) Dong Wang et al.   NEURON

Low- and high-threshold primary afferent inputs to spinal lamina III antenna-type neurons

(2018) Elisabete C. Fernandes et al.   PAIN

Neuropathic Pain models caused by damage to central or peripheral nervous system

(2018) Anil Kumar et al.   Pharmacological Reports

The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord

(2018) Adalberto Merighi   PROGRESS IN NEUROBIOLOGY

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections

(2018) Yuanyuan Liu et al.   NATURE

Timing Mechanisms Underlying Gate Control by Feedforward Inhibition

(2018) Yan Zhang et al.   NEURON

Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn

(2018) Allen C. Dickie et al.   PAIN

5-HT2A Receptor-Induced Morphological Reorganization of PKCγ-Expressing Interneurons Gates Inflammatory Mechanical Allodynia in Rat

(2018) Cristina Alba-Delgado et al.   JOURNAL OF NEUROSCIENCE

Identifying the pathways required for coping behaviours associated with sustained pain

(2018) Tianwen Huang et al.   NATURE

Expression of Calretinin Among Different Neurochemical Classes of Interneuron in the Superficial Dorsal Horn of the Mouse Spinal Cord

(2018) Maria Gutierrez-Mecinas et al.   NEUROSCIENCE

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn

(2017) Andrew J Todd   Molecular Pain

Identification of spinal circuits involved in touch-evoked dynamic mechanical pain

(2017) Longzhen Cheng et al.   NATURE NEUROSCIENCE

A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins

(2017) Amaury François et al.   NEURON

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

(2017) Shuohao Sun et al.   NEURON

RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait

(2017) Stephanie C. Koch et al.   NEURON

A quantitative study of neurochemically defined populations of inhibitory interneurons in the superficial dorsal horn of the mouse spinal cord

(2017) Kieran A. Boyle et al.   NEUROSCIENCE

Pax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn

(2017) Max Larsson   NEUROSCIENCE LETTERS

Preprotachykinin A is expressed by a distinct population of excitatory neurons in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli

(2017) Maria Gutierrez-Mecinas et al.   PAIN

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Protein Kinase C γ Interneurons Mediate C-fiber–induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber–induced Nociceptive Behavior

(2016) Cedric Peirs et al.   ANESTHESIOLOGY

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord

(2016) Ming-Dong Zhang et al.   Brain Structure & Function

Making sense out of spinal cord somatosensory development

(2016) Helen C. Lai et al.   DEVELOPMENT

Lamina specific postnatal development of PKCγ interneurons within the rat medullary dorsal horn

(2016) Noemie Mermet-Joret et al.   Developmental Neurobiology

Toward a Mechanism-Based Approach to Pain Diagnosis

(2016) Daniel Vardeh et al.   JOURNAL OF PAIN

A quantitative study of neurochemically defined excitatory interneuron populations in laminae I–III of the mouse spinal cord

(2016) Maria Gutierrez-Mecinas et al.   Molecular Pain

Identification of Early RET+ Deep Dorsal Spinal Cord Interneurons in Gating Pain

(2016) Lian Cui et al.   NEURON

Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-positive neuron excitability in the spinal cord dorsal horn

(2016) K.M. Smith et al.   NEUROSCIENCE

Neuronal networks and nociceptive processing in the dorsal horn of the spinal cord

(2016) Matilde Cordero-Erausquin et al.   NEUROSCIENCE

A combined electrophysiological and morphological study of neuropeptide Y–expressing inhibitory interneurons in the spinal dorsal horn of the mouse

(2016) Noboru Iwagaki et al.   PAIN

Neural circuits for pain: Recent advances and current views

(2016) C. Peirs et al.   SCIENCE

In Vivo Interrogation of Spinal Mechanosensory Circuits

(2016) Amelia J. Christensen et al.   Cell Reports

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

(2015) Steeve Bourane et al.   CELL

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibitory Interneurons That Express GFP in the PrP-GFP Mouse Spinal Cord Are Morphologically Heterogeneous, Innervated by Several Classes of Primary Afferent and Include Lamina I Projection Neurons among Their Postsynaptic Targets

(2015) R. P. Ganley et al.   JOURNAL OF NEUROSCIENCE

Functional heterogeneity of calretinin-expressing neurons in the mouse superficial dorsal horn: implications for spinal pain processing

(2015) K. M. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeted Ablation, Silencing, and Activation Establish Glycinergic Dorsal Horn Neurons as Key Components of a Spinal Gate for Pain and Itch

(2015) Edmund Foster et al.   NEURON

Dorsal Horn Circuits for Persistent Mechanical Pain

(2015) Cedric Peirs et al.   NEURON

Subpopulations of PKCγ interneurons within the medullary dorsal horn revealed by electrophysiologic and morphologic approach

(2015) Cristina Alba-Delgado et al.   PAIN

The organisation of spinoparabrachial neurons in the mouse

(2015) Darren Cameron et al.   PAIN

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

(2015) S. Bourane et al.   SCIENCE

Origin of a Non-Clarke’s Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function

(2015) Rachel Yuengert et al.   Cell Reports

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury

(2015) Hugues Petitjean et al.   Cell Reports

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

Peripherally driven low-threshold inhibitory inputs to lamina I local-circuit and projection neurones: a new circuit for gating pain responses

(2014) Liliana L. Luz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of a cellular node for motor control pathways

(2014) Ariel J Levine et al.   NATURE NEUROSCIENCE

Transmitting Pain and Itch Messages: A Contemporary View of the Spinal Cord Circuits that Generate Gate Control

(2014) João Braz et al.   NEURON

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury

(2014) M.-D. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia

(2013) Yan Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Protein kinase C gamma interneurons in the rat medullary dorsal horn: Distribution and synaptic inputs to these neurons, and subcellular localization of the enzyme

(2013) Cédric Peirs et al.   JOURNAL OF COMPARATIVE NEUROLOGY

An Overview of Animal Models of Pain: Disease Models and Outcome Measures

(2013) Nicholas S. Gregory et al.   JOURNAL OF PAIN

Morphological, biophysical and synaptic properties of glutamatergic neurons of the mouse spinal dorsal horn

(2013) Pradeep Punnakkal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neurochemical Characterisation of Lamina II Inhibitory Interneurons that Express GFP in the PrP-GFP Mouse

(2013) Noboru Iwagaki et al.   Molecular Pain

Improved tools for the Brainbow toolbox

(2013) Dawen Cai et al.   NATURE METHODS

Excitatory Superficial Dorsal Horn Interneurons Are Functionally Heterogeneous and Required for the Full Behavioral Expression of Pain and Itch

(2013) Xidao Wang et al.   NEURON

The Sensory Neurons of Touch

(2013) Victoria E. Abraira et al.   NEURON

Functional differences between neurochemically defined populations of inhibitory interneurons in the rat spinal dorsal horn

(2013) Erika Polgár et al.   PAIN

Sensory profiles of patients with neuropathic pain based on the neuropathic pain symptoms and signs

(2013) Roy Freeman et al.   PAIN

A Transcription Factor Code Defines Nine Sensory Interneuron Subtypes in the Mechanosensory Area of the Spinal Cord

(2013) Marta Garcia Del Barrio et al.   PLoS One

A Quantitative Study of Inhibitory Interneurons in Laminae I-III of the Mouse Spinal Dorsal Horn

(2013) Erika Polgár et al.   PLoS One

Projection Neurons in Lamina III of the Rat Spinal Cord Are Selectively Innervated by Local Dynorphin-Containing Excitatory Neurons

(2012) N. Baseer et al.   JOURNAL OF NEUROSCIENCE

Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn

(2012) D. I. Hughes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain

(2012) João M. Bráz et al.   NEURON

Fast Synaptic Inhibition in Spinal Sensory Processing and Pain Control

(2012) Hanns Ulrich Zeilhofer et al.   PHYSIOLOGICAL REVIEWS

Genetic marking and characterization of Tac2-expressing neurons in the central and peripheral nervous system

(2012) Lynn Mar et al.   Molecular Brain

Chronic Pain States: Pharmacological Strategies to Restore Diminished Inhibitory Spinal Pain Control

(2011) Hanns Ulrich Zeilhofer et al.   Annual Review of Pharmacology and Toxicology

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain

(2011) Qinghao Xu et al.   Current Opinion in Anesthesiology

Assessing symptom profiles in neuropathic pain clinical trials: Can it improve outcome?

(2011) Nadine Attall et al.   EUROPEAN JOURNAL OF PAIN

Dynorphin is Expressed Primarily by GABAergic Neurons That Contain Galanin in the Rat Dorsal Horn

(2011) Thomas CP Sardella et al.   Molecular Pain

Galanin-Immunoreactivity Identifies a Distinct Population of Inhibitory Interneurons in Laminae I-III of the Rat Spinal Cord

(2011) Sheena YX Tiong et al.   Molecular Pain

A quantitative study of neuronal nitric oxide synthase expression in laminae I–III of the rat spinal dorsal horn

(2011) T.C.P. Sardella et al.   NEUROSCIENCE

Intrathecal Lentiviral-Mediated RNA Interference Targeting PKCγ Attenuates Chronic Constriction Injury–Induced Neuropathic Pain in Rats

(2010) Wangyuan Zou et al.   HUMAN GENE THERAPY

Quantitative analysis of spinothalamic tract neurons in adult and developing mouse

(2010) Steve Davidson et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn

(2010) Erika Polgár et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia

(2010) Yong-Jing Gao et al.   JOURNAL OF NEUROCHEMISTRY

Clarke's column neurons as the focus of a corticospinal corollary circuit

(2010) Adam W Hantman et al.   NATURE NEUROSCIENCE

Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach

(2010) Toshiharu Yasaka et al.   PAIN

Dorsal horn neurons presynaptic to lamina I spinoparabrachial neurons revealed by transynaptic labeling

(2009) Matilde Cordero-Erausquin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enkephalins, dynorphins, and β-endorphin in the rat dorsal horn: An immunofluorescence colocalization study

(2009) Juan Carlos G. Marvizón et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area

(2009) Khulood M. Al-Khater et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Organization of Intralaminar and Translaminar Neuronal Connectivity in the Superficial Spinal Dorsal Horn

(2009) G. Kato et al.   JOURNAL OF NEUROSCIENCE

Glycine Inhibitory Dysfunction Induces a Selectively Dynamic, Morphine-Resistant, and Neurokinin 1 Receptor- Independent Mechanical Allodynia

(2009) L. S. Miraucourt et al.   JOURNAL OF NEUROSCIENCE

Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn

(2009) K.S. Al Ghamdi et al.   NEUROSCIENCE

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord

(2008) Khulood M. Al-Khater et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Large Projection Neurons in Lamina I of the Rat Spinal Cord That Lack the Neurokinin 1 Receptor Are Densely Innervated by VGLUT2-Containing Axons and Possess GluR4-Containing AMPA Receptors

(2008) E. Polgar et al.   JOURNAL OF NEUROSCIENCE

Descending Serotonergic Controls Regulate Inflammation-Induced Mechanical Sensitivity and Methyl-CpG-Binding Protein 2 Phosphorylation in the Rat Superficial Dorsal Horn

(2008) Sandrine M Géranton et al.   Molecular Pain

Prevalence of chronic pain with neuropathic characteristics in the general population

(2007) Didier Bouhassira et al.   PAIN