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Title
Genome engineering of stem cell organoids for disease modeling
Authors
Keywords
pluripotent/adult stem cell, tissue organoid, genome editing, precision medicine
Journal
Protein & Cell
Volume 8, Issue 5, Pages 315-327
Publisher
Springer Nature
Online
2017-01-19
DOI
10.1007/s13238-016-0368-0
References
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- (2008) Nicolas Gaspard et al. NATURE
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