Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement

Effect of 2 Years of Treatment With Sublingual Grass Pollen Immunotherapy on Nasal Response to Allergen Challenge at 3 Years Among Patients With Moderate to Severe Seasonal Allergic Rhinitis

(2017) Guy W. Scadding et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity

(2017) Christoph Göbl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T Cell Epitope Peptide Therapy for Allergic Diseases

(2016) Robyn E. O’Hehir et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Vaccine development for allergen-specific immunotherapy based on recombinant allergens and synthetic allergen peptides: Lessons from the past and novel mechanisms of action for the future

(2016) Rudolf Valenta et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy of 2 months of allergen-specific immunotherapy with Bet v 1–derived contiguous overlapping peptides in patients with allergic rhinoconjunctivitis: Results of a phase IIb study

(2016) François Spertini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Treatment effect of sublingual immunotherapy tablets and pharmacotherapies for seasonal and perennial allergic rhinitis: Pooled analyses

(2016) Stephen R. Durham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Effect of Avoidance on Peanut Allergy after Early Peanut Consumption

(2016) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets

(2016) John F. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms, safety and efficacy of a B cell epitope-based vaccine for immunotherapy of grass pollen allergy

(2016) Petra Zieglmayer et al.   EBioMedicine

Local and systemic effects of cat allergen nasal provocation

(2015) G. W. Scadding et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects

(2015) P. Couroux et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy

(2015) Margarete Focke-Tejkl et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hypoallergenic derivatives of Fel d 1 obtained by rational reassembly for allergy vaccination and tolerance induction

(2014) M. Curin et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Enlarging the repertoire of therapeutic monoclonal antibodies platforms: domesticating half molecule exchange to produce stable IgG4 and IgG1 bispecific antibodies

(2014) Xiaoyu Yang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

(2014) Jennifer D. Hamilton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

(2014) L. E. Macdonald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

(2014) A. J. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IgG-mediated down-regulation of IgE bound to mast cells: a potential novel mechanism of allergen-specific desensitization

(2013) C. Uermösi et al.   ALLERGY

An integrated analysis of the efficacy of fluticasone furoate nasal spray versus placebo on the nasal symptoms of perennial allergic rhinitis

(2013) Wei Wu et al.   ALLERGY AND ASTHMA PROCEEDINGS

Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy

(2012) Sabine Flicker et al.   IMMUNOBIOLOGY

SQ-standardized sublingual grass immunotherapy: Confirmation of disease modification 2 years after 3 years of treatment in a randomized trial

(2012) Stephen R. Durham et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

(2011) M. H. Shamji et al.   ALLERGY

Cat allergen-induced blood basophil reactivity in vitro predicts acute human nasal allergen challenge responses in vivo

(2011) M. Paterniti et al.   CLINICAL AND EXPERIMENTAL ALLERGY

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(2011)   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge

(2011) Grant C. Nicholson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A hypoallergenic cat vaccine based on Fel d 1–derived peptides fused to hepatitis B PreS

(2011) Katarzyna Niespodziana et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy

(2011) Margitta Worm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Fluticasone furoate nasal spray reduces the nasal-ocular reflex: A mechanism for the efficacy of topical steroids in controlling allergic eye symptoms

(2009) Fuad M. Baroody et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clinical efficacy and immune regulation with peanut oral immunotherapy

(2009) Stacie M. Jones et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge

(2009) John A. Eckman et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Allergen skin tests and free IgE levels during reduction and cessation of omalizumab therapy

(2008) Jonathan Corren et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity

(2008) James N. Francis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY