Microbial Metabolites, Postbiotics, and Intestinal Epithelial Function

Gastrointestinal tract modeling using organoids engineered with cellular and microbiota niches

(2020) Sungjin Min et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

(2020) Aonghus Lavelle et al.   Nature Reviews Gastroenterology & Hepatology

IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations

(2020) Leo R. Fitzpatrick et al.   Frontiers in Physiology

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens

(2019) Michele Proietti et al.   Nature Communications

The neuroactive potential of the human gut microbiota in quality of life and depression

(2019) Mireia Valles-Colomer et al.   Nature Microbiology

A Novel Postbiotic From Lactobacillus rhamnosus GG With a Beneficial Effect on Intestinal Barrier Function

(2019) Jie Gao et al.   Frontiers in Microbiology

Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis

(2019) Maaike Vancamelbeke et al.   Journal of Crohns & Colitis

Characteristics and pathogenic role of adherent-invasive Escherichia coli in inflammatory bowel disease: Potential impact on clinical outcomes

(2019) Jae Gon Lee et al.   PLoS One

Postbiotic metabolites produced by Lactobacillus plantarum strains exert selective cytotoxicity effects on cancer cells

(2019) Li-Oon Chuah et al.   BMC Complementary and Alternative Medicine

Intestinal Inflammation Modulates the Epithelial Response to Butyrate in Patients With Inflammatory Bowel Disease

(2019) Elena Ferrer-Picón et al.   INFLAMMATORY BOWEL DISEASES

Postbiotic L. plantarum RG14 improves ruminal epithelium growth, immune status and upregulates the intestinal barrier function in post-weaning lambs

(2019) Wan Ibrahim Izuddin et al.   Scientific Reports

Gut microbiota and butyrate level changes associated with the long-term administration of proton pump inhibitors to old rats

(2019) Sun Min Lee et al.   Scientific Reports

Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond

(2019) Wegh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells

(2019) Yoshiyuki Goto   Frontiers in Immunology

Microbial Metabolites Determine Host Health and the Status of Some Diseases

(2019) Panida Sittipo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gut Microbial Metabolites and Biochemical Pathways Involved in Irritable Bowel Syndrome: Effects of Diet and Nutrition on the Microbiome

(2019) Shanalee C James et al.   JOURNAL OF NUTRITION

Lactobacillus accelerates ISCs regeneration to protect the integrity of intestinal mucosa through activation of STAT3 signaling pathway induced by LPLs secretion of IL-22

(2018) Qihang Hou et al.   CELL DEATH AND DIFFERENTIATION

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Urinary Polyamine Biomarker Panels with Machine-Learning Differentiated Colorectal Cancers, Benign Disease, and Healthy Controls

(2018) Tetsushi Nakajima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids

(2018) B. van der Hee et al.   Stem Cell Research

Postbiotics: An evolving term within the functional foods field

(2018) J.E. Aguilar-Toalá et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

(2018) Rachel Fellows et al.   Nature Communications

Effects of the intestinal microbial metabolite butyrate on the development of colorectal cancer

(2018) Xinqiang Wu et al.   Journal of Cancer

Bioactive polyamine production by a novel hybrid system comprising multiple indigenous gut bacterial strategies

(2018) Yusuke Kitada et al.   Science Advances

Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT

(2018) Jotham Suez et al.   CELL

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

(2018) Niv Zmora et al.   CELL

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

OUP accepted manuscript

(2018)   Advances in Nutrition

In vitro study of postbiotics from Lactobacillus plantarum RG14 on rumen fermentation and microbial population

(2018) Wan Ibrahim Izuddin et al.   REVISTA BRASILEIRA DE ZOOTECNIA-BRAZILIAN JOURNAL OF ANIMAL SCIENCE

Gut microbiome structure and metabolic activity in inflammatory bowel disease

(2018) Eric A. Franzosa et al.   Nature Microbiology

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Adherent-invasiveEscherichia coliin inflammatory bowel disease

(2017) Carolina Palmela et al.   GUT

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

(2017) Felipe Melo-Gonzalez et al.   IMMUNOLOGY

Extracellular ATP and adenosine: The Yin and Yang in immune responses?

(2017) M.M. Faas et al.   MOLECULAR ASPECTS OF MEDICINE

Correlation between in vitro and in vivo assays in selection of probiotics from traditional species of bacteria

(2017) Gabriel Vinderola et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Quantitative metabolomics for investigating the value of polyamines in the early diagnosis and therapy of colorectal cancer

(2017) Ran Liu et al.   Oncotarget

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

(2017) Lisa Perruzza et al.   Cell Reports

Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

(2017) David R Hill et al.   eLife

The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1β-induced inflammation in human fetal enterocytes via toll receptors 2 and 4

(2017) Fei Jiang et al.   PLoS One

Lactobacillus rhamnosus GG supernatant enhance neonatal resistance to systemic Escherichia coli K1 infection by accelerating development of intestinal defense

(2017) Xiaolong He et al.   Scientific Reports

Biosynthesis of polyamines and polyamine-containing molecules

(2016) A. J. Michael   BIOCHEMICAL JOURNAL

Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success

(2016) John A. Halsall et al.   BIOESSAYS

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Fragmented Lactic Acid Bacterial Cells Activate Peroxisome Proliferator-Activated Receptors and Ameliorate Dyslipidemia in Obese Mice

(2016) Futoshi Nakamura et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Extracellular purines, purinergic receptors and tumor growth

(2016) F Di Virgilio et al.   ONCOGENE

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

(2016) Tze Guan Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal stem cell growth and differentiation on a tubular scaffold with evaluation in small and large animals

(2016) Shahab A Shaffiey et al.   Regenerative Medicine

Role and mechanisms of action ofEscherichia coliNissle 1917 in the maintenance of remission in ulcerative colitis patients: An update

(2016) Franco Scaldaferri et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Colon microbiota fermentation of dietary prebiotics towards short-chain fatty acids and their roles as anti-inflammatory and antitumour agents: A review

(2016) Javier Fernández et al.   Journal of Functional Foods

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Escherichia coli Nissle 1917 enhances bioavailability of serotonin in gut tissues through modulation of synthesis and clearance

(2015) Jonathan Nzakizwanayo et al.   Scientific Reports

Isolation of Genetically Tractable Most-Wanted Bacteria by Metaparental Mating

(2015) Páraic Ó Cuív et al.   Scientific Reports

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

(2014) Suryasarathi Dasgupta et al.   Cell Host & Microbe

ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

(2014) Michele Proietti et al.   IMMUNITY

Fusobacterium and Enterobacteriaceae: Important players for CRC?

(2014) Emma Allen-Vercoe et al.   IMMUNOLOGY LETTERS

Postbiotic Activities of Lactobacilli-derived Factors

(2014) Alessia Cicenia et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

TLR Costimulation Causes Oxidative Stress with Unbalance of Proinflammatory and Anti-Inflammatory Cytokine Production

(2014) R. Lavieri et al.   JOURNAL OF IMMUNOLOGY

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn’s disease and healthy individuals

(2014) Jacob Tveiten Bjerrum et al.   Metabolomics

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Lactobacillus paracasei CBA L74 Metabolic Products and Fermented Milk for Infant Formula Have Anti-Inflammatory Activity on Dendritic Cells In Vitro and Protective Effects against Colitis and an Enteric Pathogen In Vivo

(2014) Elena Zagato et al.   PLoS One

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

Understanding Host-Adherent-InvasiveEscherichia coliInteraction in Crohn’s Disease: Opening Up New Therapeutic Strategies

(2014) Allison Agus et al.   Biomed Research International

Release of extracellular ATP by bacteria during growth

(2013) Roberto Mempin et al.   BMC MICROBIOLOGY

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

(2013) Elaine Y. Hsiao et al.   CELL

Lactobacillus GG-fermented milk prevents DSS-induced colitis and regulates intestinal epithelial homeostasis through activation of epidermal growth factor receptor

(2013) Kazutoyo Yoda et al.   EUROPEAN JOURNAL OF NUTRITION

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Functional genomic analyses of the gut microbiota for CRC screening

(2013) Sergey R. Konstantinov et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

(2012) Katerina Tsilingiri et al.   GUT

FAO/WHO Guidelines on Probiotics

(2012) Lorenzo Morelli et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Cell-Free Supernatants from ProbioticLactobacillus caseiandLactobacillus rhamnosusGG Decrease Colon Cancer Cell Invasion In Vitro

(2012) Juanita Escamilla et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

A Pivotal Role of Vitamin B9 in the Maintenance of Regulatory T Cells In Vitro and In Vivo

(2012) Jun Kunisawa et al.   PLoS One

Abating colon cancer polyposis by Lactobacillus acidophilus deficient in lipoteichoic acid

(2012) K. Khazaie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella entericaserovars Typhimurium and Typhi as model organisms

(2012) Preeti Garai et al.   Virulence

Postbiotics: what else?

(2012) K. Tsilingiri et al.   Beneficial Microbes

Importance of Confirming Data on theIn VivoEfficacy of Novel Antibacterial Drug Regimens against Various Strains of Mycobacterium tuberculosis

(2011) Mary A. De Groote et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ProbioticEscherichia coliNissle 1917 Reduces Pathogen Invasion and Modulates Cytokine Expression in Caco-2 Cells Infected with Crohn's Disease-AssociatedE. coliLF82

(2011) Claudia Huebner et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Oral inoculation of probiotics Lactobacillus acidophilus NCFM suppresses tumour growth both in segmental orthotopic colon cancer and extra-intestinal tissue

(2011) Chien-Chang Chen et al.   BRITISH JOURNAL OF NUTRITION

Explant culture of gastrointestinal tissue: a review of methods and applications

(2011) Kevin J. Randall et al.   CELL BIOLOGY AND TOXICOLOGY

The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon

(2011) Dallas R. Donohoe et al.   Cell Metabolism

Genomic analysis identifies association of Fusobacterium with colorectal carcinoma

(2011) A. D. Kostic et al.   GENOME RESEARCH

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Low intake of vitamin B6 is associated with irritable bowel syndrome symptoms

(2011) Solveig C. Ligaarden et al.   NUTRITION RESEARCH

Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway

(2011) Shuichi Segawa et al.   PLoS One

Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease

(2011) Rian M. Nijmeijer et al.   PLoS One

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

Hypocholesterolemic effect of sonication-killed Bifidobacterium longum isolated from healthy adult Koreans in high cholesterol fed rats

(2010) Hea Soon Shin et al.   ARCHIVES OF PHARMACAL RESEARCH

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and Identification of ATP-Secreting Bacteria from Mice and Humans

(2010) T. Iwase et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Biofilm formation as a novel phenotypic feature of adherent-invasive Escherichia coli (AIEC)

(2009) Margarita Martinez-Medina et al.   BMC MICROBIOLOGY

Role of interleukin-1β during pain and inflammation

(2009) Ke Ren et al.   BRAIN RESEARCH REVIEWS

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Molecular diversity of Escherichia coli in the human gut: New ecological evidence supporting the role of adherent-invasive E. coli (AIEC) in Crohnʼs disease

(2009) Margarita Martinez-Medina et al.   INFLAMMATORY BOWEL DISEASES

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

In vitroinhibition activity of different bacteriocin-producingEscherichia coliagainstSalmonellastrains isolated from clinical cases

(2009) A. Zihler et al.   LETTERS IN APPLIED MICROBIOLOGY

Unknown

(2009) Shu Zhu et al.   MOLECULAR MEDICINE

Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans

(2009) M Möndel et al.   Mucosal Immunology

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

Comparison of the Immunomodulatory Properties of Three Probiotic Strains of Lactobacilli Using Complex Culture Systems: Prediction for In Vivo Efficacy

(2009) Erika Mileti et al.   PLoS One

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of probiotic therapy in IBD

(2008) Kim Isaacs et al.   INFLAMMATORY BOWEL DISEASES

Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases

(2008) Charles Vanderpool et al.   INFLAMMATORY BOWEL DISEASES

Clinical use of E. coli Nissle 1917 in inflammatory bowel disease

(2008) Michael Schultz   INFLAMMATORY BOWEL DISEASES

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

(2008) Li Wen et al.   NATURE

Intestinal bile acid physiology and pathophysiology

(2008) Olga Martínez-Augustin et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Escherichia coli isolated from a Crohn's disease patient adheres, invades, and induces inflammatory responses in polarized intestinal epithelial cells

(2007) Tonyia Eaves-Pyles et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY