Histone deacetylase inhibitors for cancer therapy: An evolutionarily ancient resistance response may explain their limited success

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Sulforaphane suppresses in vitro and in vivo lung tumorigenesis through downregulation of HDAC activity

(2016) Li-Li Jiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors

(2016) Damodara N. Reddy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism

(2016) Di You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines

(2016) Maria Pinkerneil et al.   Targeted Oncology

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

(2016) Shahaf Peleg et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells

(2016) Huang Zhijun et al.   TUMOR BIOLOGY

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

A Role for Nuclear Actin in HDAC 1 and 2 Regulation

(2016) Leonid A. Serebryannyy et al.   Scientific Reports

Epigenetic linkage of aging, cancer and nutrition

(2015) M. Daniel et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Histone Deacetylase Inhibitors: A Review on Class-I Specific Inhibition

(2015) Jagannath Behera et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Eukaryotes really are special, and mitochondria are why

(2015) Nick Lane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early Microbial Evolution: The Age of Anaerobes

(2015) William F. Martin et al.   Cold Spring Harbor Perspectives in Biology

Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response

(2015) John A Halsall et al.   Epigenetics & Chromatin

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

(2015) Bidisha Paul et al.   Clinical Epigenetics

Molecular mechanisms involved inBacillus subtilisbiofilm formation

(2014) Benjamin Mielich-Süss et al.   ENVIRONMENTAL MICROBIOLOGY

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paleobiological Perspectives on Early Eukaryotic Evolution

(2014) A. H. Knoll   Cold Spring Harbor Perspectives in Biology

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae

(2013) Wanessa D Wight et al.   BMC MICROBIOLOGY

The promise and failures of epigenetic therapies for cancer treatment

(2013) Pasano Bojang et al.   CANCER TREATMENT REVIEWS

Beneficial Metabolic Effects of a Probiotic via Butyrate-induced GLP-1 Hormone Secretion

(2013) Hariom Yadav et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

Loss of Nucleosomal DNA Condensation Coincides with Appearance of a Novel Nuclear Protein in Dinoflagellates

(2012) Sebastian G. Gornik et al.   CURRENT BIOLOGY

Discovery and Mechanism of Natural Products as Modulators of Histone Acetylation

(2012) Lilibeth A. Salvador et al.   CURRENT DRUG TARGETS

Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets

(2012) Matthias G. J. Baud et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorescent analogs of the marine natural product psammaplin A: synthesis and biological activity

(2012) Fabia Hentschel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors

(2012) John Halsall et al.   PLoS One

The adjustable nucleosome: an epigenetic signaling module

(2012) Bryan M. Turner   TRENDS IN GENETICS

Nucleosome Structure(s) and Stability: Variations on a Theme

(2011) Andrew J. Andrews et al.   Annual Review of Biophysics

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux

(2010) Q. Wang et al.   SCIENCE

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

(2009) Petra Louis et al.   FEMS MICROBIOLOGY LETTERS

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Genetic dissection of histone deacetylase requirement in tumor cells

(2009) M. Haberland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone modifying enzymes: Structures, mechanisms, and specificities

(2008) Ronen Marmorstein et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine CyanobacteriumSymplocasp.

(2008) Kanchan Taori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS