Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations

Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus

(2015) Manickavasagom Alkondon et al.   BIOCHEMICAL PHARMACOLOGY

Targeting key dioxygenases in tryptophan–kynurenine metabolism for immunomodulation and cancer chemotherapy

(2015) Christopher J.D. Austin et al.   DRUG DISCOVERY TODAY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

(2014) Jazmin Reyes Ocampo et al.   Oxidative Medicine and Cellular Longevity

Identification of Cinnabarinic Acid as a Novel Endogenous Aryl Hydrocarbon Receptor Ligand That Drives IL-22 Production

(2014) Margaret M. Lowe et al.   PLoS One

The Aryl Hydrocarbon Receptor Meets Immunology: Friend or Foe? A Little of Both

(2014) Walker Julliard et al.   Frontiers in Immunology

The Role of the Immune System in Huntington’s Disease

(2013) Gisa Ellrichmann et al.   Clinical & Developmental Immunology

Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response

(2013) Christoph F. A. Vogel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis

(2013) Peter A. LeWitt et al.   MOVEMENT DISORDERS

Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer’s disease patients from controls

(2012) Markus J. Schwarz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat

(2012) Virginie Chauvel et al.   EXPERIMENTAL NEUROLOGY

Some molecular mechanisms of dopaminergic and glutamatergic dysfunctioning in Parkinson’s disease

(2012) Dénes Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

Kynurenines in the CNS: recent advances and new questions

(2012) László Vécsei et al.   NATURE REVIEWS DRUG DISCOVERY

3-Hydroxykynurenine: An intriguing molecule exerting dual actions in the Central Nervous System

(2012) Ana Laura Colín-González et al.   NEUROTOXICOLOGY

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

(2011) Levente Gellért et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modifications on the carboxylic function of kynurenic acid

(2011) Ferenc Fülöp et al.   JOURNAL OF NEURAL TRANSMISSION

Behavioural studies with a newly developed neuroprotective KYNA-amide

(2011) Levente Gellért et al.   JOURNAL OF NEURAL TRANSMISSION

The kynurenine system and immunoregulation

(2011) Yvette Mándi et al.   JOURNAL OF NEURAL TRANSMISSION

Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

(2011) Valentina Durastanti et al.   Journal of Translational Medicine

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

(2011) Zoltán Tiszlavicz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Protective effect of systemic l-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25–35) in rat hippocampus

(2010) Paul Carrillo-Mora et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington’s disease

(2010) Dénes Zádori et al.   JOURNAL OF NEURAL TRANSMISSION

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Protective effect of l-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: Implications of modulating kynurenate as a protective strategy

(2010) Daniela Silva-Adaya et al.   NEUROTOXICOLOGY AND TERATOLOGY

Glutamate receptors, neurotoxicity and neurodegeneration

(2010) Anthony Lau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Kynurenic Acid Is a Potent Endogenous Aryl Hydrocarbon Receptor Ligand that Synergistically Induces Interleukin-6 in the Presence of Inflammatory Signaling

(2010) Brett C. DiNatale et al.   TOXICOLOGICAL SCIENCES

Syntheses, Transformations and Pharmaceutical Applications of Kynurenic Acid Derivatives

(2009) F. Fulop et al.   CURRENT MEDICINAL CHEMISTRY

A novel kynurenic acid analogue: a comparison with kynurenic acid. An in vitro electrophysiological study

(2009) Máté Marosi et al.   JOURNAL OF NEURAL TRANSMISSION

On the relationship between the two branches of the kynurenine pathway in the rat brainin vivo

(2009) Laura Amori et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis

(2009) Yiquan Chen et al.   NEUROTOXICITY RESEARCH

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

(2008) Jasminka Mizdrak et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Janus-face kynurenic acid

(2008) Éva Rózsa et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate

(2008) Hermina Robotka et al.   LIFE SCIENCES

Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

(2008) Katalin Sas et al.   NEUROBIOLOGY OF DISEASE

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

(2008) Thomas J. Connor et al.   NEUROSCIENCE LETTERS

Abnormal Liver Development and Resistance to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Toxicity in Mice Carrying a Mutation in the DNA-Binding Domain of the Aryl Hydrocarbon Receptor

(2008) Maureen K. Bunger et al.   TOXICOLOGICAL SCIENCES

Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

(2007) L GREGOIRE et al.   BEHAVIOURAL BRAIN RESEARCH

GPR35 is a functional receptor in rat dorsal root ganglion neurons

(2007) Hiroyuki Ohshiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS