IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis

Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis

(2018) Brian O. Diekman et al.   AGING CELL

Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis

(2018) David W Waters et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Senescent cells and osteoarthritis: a painful connection

(2018) Ok Hee Jeon et al.   JOURNAL OF CLINICAL INVESTIGATION

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Systemic inflammation and painful joint burden in osteoarthritis: a matter of sex?

(2017) A.V. Perruccio et al.   OSTEOARTHRITIS AND CARTILAGE

Making Mouse Models That Reflect Human Immune Responses

(2017) Lili Tao et al.   TRENDS IN IMMUNOLOGY

Innate Lymphoid Cells (ILCs) as Mediators of Inflammation, Release of Cytokines and Lytic Molecules

(2017) Noha Elemam et al.   Toxins

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

(2017) Cornelia Symowski et al.   Frontiers in Immunology

Cellular senescence impact on immune cell fate and function

(2016) Rita Vicente et al.   AGING CELL

IL-23/IL-17 axis in spondyloarthritis-bench to bedside

(2016) Siba P. Raychaudhuri et al.   CLINICAL RHEUMATOLOGY

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis

(2016) Alireza Askari et al.   PLoS One

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

(2016) K. Sadtler et al.   SCIENCE

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Secukinumab for ankylosing spondylitis and psoriatic arthritis

(2016) Ennio Lubrano et al.   Therapeutics and Clinical Risk Management

The role of inflammation in age-related disease

(2016) T. Kevin Howcroft et al.   Aging-US

IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy

(2016) Neal L. Millar et al.   Scientific Reports

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Role of IL-17 in the pathogenesis of psoriatic arthritis and axial spondyloarthritis

(2015) Smriti K Raychaudhuri et al.   CLINICAL RHEUMATOLOGY

Inhibition of interleukin-17, interleukin-23 and the TH17 cell pathway in the treatment of psoriatic arthritis and psoriasis

(2015) Philip J. Mease   CURRENT OPINION IN RHEUMATOLOGY

LIF signaling in stem cells and development

(2015) K. Onishi et al.   DEVELOPMENT

Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

(2015) Michelle L Robinette et al.   NATURE IMMUNOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

The central role of muscle stem cells in regenerative failure with aging

(2015) Helen M Blau et al.   NATURE MEDICINE

Erratum: The IL-23–IL-17 axis in inflammatory arthritis

(2015) Erik Lubberts   Nature Reviews Rheumatology

Knockdown of the Cell Cycle Inhibitor p21 Enhances Cartilage Formation by Induced Pluripotent Stem Cells

(2015) Brian O. Diekman et al.   TISSUE ENGINEERING PART A

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Mouse models of osteoarthritis: modelling risk factors and assessing outcomes

(2014) Hang Fang et al.   Nature Reviews Rheumatology

Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis

(2013) D A Binks et al.   ANNALS OF THE RHEUMATIC DISEASES

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

(2013) Jose E. Heredia et al.   CELL

The Th17/Treg balance is disturbed during aging

(2013) Vanessa Schmitt et al.   EXPERIMENTAL GERONTOLOGY

Causes, consequences, and reversal of immune system aging

(2013) Encarnacion Montecino-Rodriguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Association between severity of knee osteoarthritis and serum and synovial fluid interleukin 17 concentrations

(2013) Biao Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model

(2013) M.Z.C. Ruan et al.   OSTEOARTHRITIS AND CARTILAGE

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

(2013) M. Z. C. Ruan et al.   Science Translational Medicine

Terminally Differentiated CD8+ T Cells Negatively Affect Bone Regeneration in Humans

(2013) S. Reinke et al.   Science Translational Medicine

Role of Interleukin-1 Inhibitors in Osteoarthritis

(2012) Zdravko Jotanovic et al.   DRUGS & AGING

IL-23: One cytokine in control of autoimmunity

(2012) Andrew L. Croxford et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-17 contributes to cardiac fibrosis following experimental autoimmune myocarditis by a PKC /Erk1/2/NF- B-dependent signaling pathway

(2012) Y. Liu et al.   INTERNATIONAL IMMUNOLOGY

The Puzzle of Generalized Osteoarthritis (OA) -- Is OA a Systemic Enthesopathy?

(2012) I. K. HAUGEN   JOURNAL OF RHEUMATOLOGY

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

(2012) Jane J. Sohn et al.   PLoS One

CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis

(2012) R. E. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and wound healing: the role of the macrophage

(2011) Timothy J. Koh et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

LIF in the regulation of T-cell fate and as a potential therapeutic

(2011) S M Metcalfe   GENES AND IMMUNITY

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF- 1-Dependent and -Independent Mechanisms

(2011) S. Mi et al.   JOURNAL OF IMMUNOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Osteoarthritis: can anti-cytokine therapy play a role in treatment?

(2010) Ana Luisa G. Calich et al.   CLINICAL RHEUMATOLOGY

Age-related changes in immune function: Effect on airway inflammation

(2010) Paula J. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

(2010) Wyndham H Wilson et al.   LANCET ONCOLOGY

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans

(2009) Lyudmila Lyakh et al.   IMMUNOLOGICAL REVIEWS

How do Regulatory T Cells Work?

(2009) A. Corthay   SCANDINAVIAN JOURNAL OF IMMUNOLOGY