Hypoxia-inducible factors and innate immunity in liver cancer

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis

(2019) Sonja Rothweiler et al.   Purinergic Signalling

Dual PD ‐1 and VEGFR ‐2 blockade promotes vascular normalization and enhances anti‐tumor immune responses in HCC

(2019) Kohei Shigeta et al.   HEPATOLOGY

NK Cell Metabolism and Tumor Microenvironment

(2019) Iñigo Terrén et al.   Frontiers in Immunology

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer

(2019) Lichun Ma et al.   CANCER CELL

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

(2019) Xian-Yang Li et al.   Cancer Discovery

Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial-mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

(2018) Jingying Zhang et al.   HEPATOLOGY

The immunology of hepatocellular carcinoma

(2018) Marc Ringelhan et al.   NATURE IMMUNOLOGY

Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma

(2018) Ghassan K. Abou-Alfa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+immune evasive triple-negative breast cancer cells

(2018) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis

(2017) Daniela Sia et al.   GASTROENTEROLOGY

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

(2017) Chun-Ping Cui et al.   GUT

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Mechanisms of hepatic stellate cell activation

(2017) Takuma Tsuchida et al.   Nature Reviews Gastroenterology & Hepatology

Novel role of semaphorin 3A in the growth and progression of hepatocellular carcinoma

(2017) Xuedong Li et al.   ONCOLOGY REPORTS

Distinct roles of ecto-nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) in liver regeneration and fibrosis

(2017) Linda Feldbrügge et al.   Purinergic Signalling

Protective role of hypoxia-inducible factor-1α-dependent CD39 and CD73 in fulminant acute liver failure

(2017) Eunyoung Tak et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

(2017) Junjie Xu et al.   Cell Death & Disease

Hypoxia inducible factor HIF-1 promotes myeloid-derived suppressor cells accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma

(2017) David Kung-Chun Chiu et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Hypoxia-Induced Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma Induces an Immunosuppressive Tumor Microenvironment to Promote Metastasis

(2016) L.-Y. Ye et al.   CANCER RESEARCH

Basic liver immunology

(2016) Bin Gao   Cellular & Molecular Immunology

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

(2016) David Kung-Chun Chiu et al.   HEPATOLOGY

A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

(2016) Mei Yee Koh et al.   HEPATOLOGY

NKp46+ natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice

(2016) Annie-Carole Tosello-Trampont et al.   HEPATOLOGY

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Overexpression of semaphorin 3A promotes tumor progression and predicts poor prognosis in hepatocellular carcinoma after curative resection

(2016) Zhi-Qiang Hu et al.   Oncotarget

Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2

(2016) Layale Yaghi et al.   Oncotarget

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

(2016) W. Liang et al.   Cancer Immunology Research

Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210

(2015) Muhammad Zaeem Noman et al.   CANCER RESEARCH

Safety and Pharmacokinetics of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma

(2015) M. Ikeda et al.   CLINICAL CANCER RESEARCH

Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesis

(2015) Chahrazade Kantari-Mimoun et al.   HEPATOLOGY

Biology of the immunomodulatory molecule HLA-G in human liver diseases

(2015) Laurence Amiot et al.   JOURNAL OF HEPATOLOGY

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

(2015) Laura J Pallett et al.   NATURE MEDICINE

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells

(2015) Huimin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrodynamic Transfection for Generation of Novel Mouse Models for Liver Cancer Research

(2014) Xin Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

(2014) Shala L. Thomas et al.   CELL CYCLE

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Lysyl oxidase-like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma

(2014) Carmen Chak-Lui Wong et al.   HEPATOLOGY

Blockade of CD47-mediated cathepsin S/protease-activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma

(2014) Terence Kin-Wah Lee et al.   HEPATOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatic Stellate Cells Orchestrate Clearance of Necrotic Cells in a Hypoxia-Inducible Factor-1 -Dependent Manner by Modulating Macrophage Phenotype in Mice

(2014) A. Mochizuki et al.   JOURNAL OF IMMUNOLOGY

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Targeting CD73 Enhances the Antitumor Activity of Anti-PD-1 and Anti-CTLA-4 mAbs

(2013) B. Allard et al.   CLINICAL CANCER RESEARCH

Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC

(2013) Mirna Balsamo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma

(2013) Yingjian Liang et al.   HEPATOLOGY

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors

(2013) Paul A. Beavis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF-induced neutrophil recruitment

(2013) V. T. Phan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression

(2013) Claudia A. Dumitru et al.   SEMINARS IN CANCER BIOLOGY

The impact of hypoxia in hepatocellular carcinoma metastasis

(2013) Carmen Chak-Lui Wong et al.   Frontiers of Medicine

Anti-VEGF/VEGFR Therapy for Cancer: Reassessing the Target

(2012) B. Sitohy et al.   CANCER RESEARCH

CD24 Is an Effector of HIF-1-Driven Primary Tumor Growth and Metastasis

(2012) S. Thomas et al.   CANCER RESEARCH

TIE2-expressing monocytes as a diagnostic marker for hepatocellular carcinoma correlates with angiogenesis

(2012) Tokuhiro Matsubara et al.   HEPATOLOGY

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis

(2012) Carmen Chak-Lui Wong et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

CD24+ Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation

(2011) Terence Kin Wah Lee et al.   Cell Stem Cell

Gene Expression Profiling of Fixed Tissues Identified Hypoxia-Inducible Factor-1α, VEGF, and Matrix Metalloproteinase-2 as Biomarkers of Lymph Node Metastasis in Hepatocellular Carcinoma

(2011) Zuo-Lin Xiang et al.   CLINICAL CANCER RESEARCH

Adenosine promotes alternative macrophage activation via A2A and A2B receptors

(2011) Balázs Csóka et al.   FASEB JOURNAL

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

(2011) Aijuan Qu et al.   HEPATOLOGY

Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence

(2011) Hiroteru Kamimura et al.   JOURNAL OF HEPATOLOGY

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

(2011) C. C.-L. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

A Seven-Gene Set Associated with Chronic Hypoxia of Prognostic Importance in Hepatocellular Carcinoma

(2010) H. van Malenstein et al.   CLINICAL CANCER RESEARCH

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic Kupffer cells

(2010) Bryan L. Copple et al.   HEPATOLOGY RESEARCH

Hypoxia-inducible adenosine A2B receptor modulates proliferation of colon carcinoma cells

(2010) De-Fu Ma et al.   HUMAN PATHOLOGY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

Antisense Hypoxia-Inducible Factor-1α Augments Transcatheter Arterial Embolization in the Treatment of Hepatocellular Carcinomas in Rats

(2009) Xueying Sun et al.   HUMAN GENE THERAPY

HIF-dependent induction of adenosine receptor A2b skews human dendritic cells to a Th2-stimulating phenotype under hypoxia

(2009) Meixiang Yang et al.   IMMUNOLOGY AND CELL BIOLOGY

Aberrant human leucocyte antigen-G expression and its clinical relevance in hepatocellular carcinoma

(2009) A. Lin et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes

(2009) Bryan L. Copple et al.   LIVER INTERNATIONAL

Adenosine receptors in regulation of dendritic cell differentiation and function

(2008) S. V. Novitskiy et al.   BLOOD

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1 , Leading to Its Oxygen-Independent Degradation

(2008) M. Y. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

A RNA antagonist of hypoxia-inducible factor-1 , EZN-2968, inhibits tumor cell growth

(2008) L. M. Greenberger et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA