Protein palmitoylation and its pathophysiological relevance

Regulation of NCX1 by palmitoylation

(2020) Caglar Gök et al.   CELL CALCIUM

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

(2019) Juan Wang et al.   Cell Reports

Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads

(2019) Shuyang Chen et al.   Nature Communications

The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function

(2019) Tamar Sapir et al.   Frontiers in Cellular Neuroscience

Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours

(2019) Han Yao et al.   Nature Biomedical Engineering

Cell contact and Nf2/Merlin-dependent regulation of TEAD palmitoylation and activity

(2019) Nam-Gyun Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells

(2019) Pengju Ou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sodium nitroprusside induces H‐Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells

(2019) Galina Goloshvili et al.   CELL BIOCHEMISTRY AND FUNCTION

Toll-like receptor mediated inflammation requires FASN-dependent MYD88 palmitoylation

(2019) Young-Chan Kim et al.   Nature Chemical Biology

Epigenetic regulation in diabetic vascular complications

(2019) Jiayu Jin et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Palmitoylation of NOD1 and NOD2 is required for bacterial sensing

(2019) Yan Lu et al.   SCIENCE

Role of the transcriptional coactivators YAP/TAZ in liver cancer

(2019) Shihao Zhang et al.   CURRENT OPINION IN CELL BIOLOGY

ZDHHC11 modulates innate immune response to DNA virus by mediating MITA–IRF3 association

(2018) Ying Liu et al.   Cellular & Molecular Immunology

Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies

(2018) Hong Jiang et al.   CHEMICAL REVIEWS

Emerging Roles of DHHC-mediated Protein S -palmitoylation in Physiological and Pathophysiological Context

(2018) Indranil De et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Fatty acyl recognition and transfer by an integral membraneS-acyltransferase

(2018) Mitra S. Rana et al.   SCIENCE

Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

(2018) Rochelle Shirin Sadeghi et al.   eLife

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis

(2018) Guy Eelen et al.   NATURE

Targeting STING with covalent small-molecule inhibitors

(2018) Simone M. Haag et al.   NATURE

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

(2018) Jenny Lange et al.   Acta Neuropathologica Communications

S-Palmitoylation Sorts Membrane Cargo for Anterograde Transport in the Golgi

(2018) Andreas M. Ernst et al.   DEVELOPMENTAL CELL

Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression

(2018) Matteo Spinelli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

(2017) Keyong Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Individual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles

(2017) Maria P. Pedro et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry

(2017) Jennifer Greaves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling

(2017) Wenqing Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease

(2017) Robert J. Andrew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase

(2017) Raffaello Verardi et al.   STRUCTURE

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model

(2017) Maria B. Bagh et al.   Nature Communications

Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade

(2017) Laurence Abrami et al.   eLife

DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling

(2017) Shaymaa Mohamed Mohamed Badawy et al.   Scientific Reports

Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills

(2017) Eleonora Napoli et al.   Scientific Reports

Physicochemical sequence characteristics that influence S-palmitoylation propensity

(2016) Krishna D. Reddy et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Decreased sensitivity of palmitoyl protein thioesterase 1-deficient neurons to chemical anoxia

(2016) Meredith Meyer et al.   METABOLIC BRAIN DISEASE

ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation

(2016) Patricia Marie-Jeanne Lievens et al.   MOLECULAR AND CELLULAR BIOLOGY

Palmitoylation in Alzheimer⿿s disease and other neurodegenerative diseases

(2016) Eunsil Cho et al.   PHARMACOLOGICAL RESEARCH

Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

(2016) Richard S. Beard et al.   Nature Communications

Chromatin remodelers: We are the drivers!!

(2016) Monica Tyagi et al.   Nucleus

Chromatin remodelers: We are the drivers!!

(2016) Monica Tyagi et al.   Nucleus

The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates HemodynamicsSignificance

(2015) Ethan P. Marin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking

(2015) Wenying Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein S-palmitoylation and cancer

(2015) Marc Yeste-Velasco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events

(2015) Lorena Agudo-Ibáñez et al.   MOLECULAR AND CELLULAR BIOLOGY

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

(2015) Malia B Potts et al.   Nature Chemical Biology

Ras moves to stay in place

(2015) Malte Schmick et al.   TRENDS IN CELL BIOLOGY

Curation of the Mammalian Palmitoylome Indicates a Pivotal Role for Palmitoylation in Diseases and Disorders of the Nervous System and Cancers

(2015) Shaun S. Sanders et al.   PLoS Computational Biology

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization

(2015) David Tse Shen Lin et al.   eLife

The Autodepalmitoylating Activity of APT Maintains the Spatial Organization of Palmitoylated Membrane Proteins

(2014) Nachiket Vartak et al.   BIOPHYSICAL JOURNAL

The Drosophila protein palmitoylome: Characterizing palmitoyl-thioesterases and DHHC palmitoyl-transferases

(2014) Barbra A. Bannan et al.   FLY

A Mechanism Regulating G Protein-coupled Receptor Signaling That Requires Cycles of Protein Palmitoylation and Depalmitoylation

(2014) Lixia Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Differential Palmitoylation States of N-Ras and H-Ras Determine Their Distinct Golgi Subcompartment Localizations

(2014) Stephen J. Lynch et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Identification ofZDHHC14as a novel human tumour suppressor gene

(2014) Marc Yeste-Velasco et al.   JOURNAL OF PATHOLOGY

The Golgi S-acylation machinery comprises zDHHC enzymes with major differences in substrate affinity and S-acylation activity

(2014) Kimon Lemonidis et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer

(2014) HTOO ZARNI OO et al.   ONCOLOGY REPORTS

2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation

(2014) Xueran Chen et al.   Stem Cell Research

Insulin-Regulated Protein Palmitoylation Impacts Endothelial Cell Function

(2013) Xiaochao Wei et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Zinc co-ordination by the DHHC cysteine-rich domain of the palmitoyltransferase Swf1

(2013) Ayelén González Montoro et al.   BIOCHEMICAL JOURNAL

Dynamic Palmitoylation Links Cytosol-Membrane Shuttling of Acyl-protein Thioesterase-1 and Acyl-protein Thioesterase-2 with That of Proto-oncogene H-Ras Product and Growth-associated Protein-43

(2013) Eryan Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

DHHC ProteinS-Acyltransferases Use Similar Ping-Pong Kinetic Mechanisms but Display Different Acyl-CoA Specificities

(2012) Benjamin C. Jennings et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels

(2012) Lijun Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant

(2012) Kazumi Motoki et al.   Brain and Behavior

Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone ProteinO-Palmitoylation to Regulate mRNA Synthesis

(2011) Chunbin Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

Palmitoylation of ketogenic enzyme HMGCS2 enhances its interaction with PPARα and transcription at the Hmgcs2 PPRE

(2010) Morris A. Kostiuk et al.   FASEB JOURNAL

Palmitoylation Controls Dopamine Transporter Kinetics, Degradation, and Protein Kinase C-dependent Regulation

(2010) James D. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational Analysis ofSaccharomyces cerevisiaeErf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes

(2010) David A. Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of Fatty-acylated Proteins in Mammalian Cells with Chemical Reporters RevealsS-Acylation of Histone H3 Variants

(2010) John P. Wilson et al.   MOLECULAR & CELLULAR PROTEOMICS

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Acyl-Protein Thioesterase 2 Catalizes the Deacylation of Peripheral Membrane-Associated GAP-43

(2010) Vanesa M. Tomatis et al.   PLoS One

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

(2009) Gabriele Siegel et al.   NATURE CELL BIOLOGY

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation

(2009) Da-Ting Lin et al.   NATURE NEUROSCIENCE

Dynamic protein palmitoylation in cellular signaling

(2009) Tsuyoshi Iwanaga et al.   PROGRESS IN LIPID RESEARCH

Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum

(2008) L. Abrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA