A Mechanism Regulating G Protein-coupled Receptor Signaling That Requires Cycles of Protein Palmitoylation and Depalmitoylation

Local palmitoylation cycles define activity-regulated postsynaptic subdomains

(2013) Yuko Fukata et al.   JOURNAL OF CELL BIOLOGY

Endothelial Cell Palmitoylproteomic Identifies Novel Lipid-Modified Targets and Potential Substrates for Protein Acyl Transferases

(2012) Ethan P. Marin et al.   CIRCULATION RESEARCH

Palmitoylation-induced Aggregation of Cysteine-string Protein Mutants That Cause Neuronal Ceroid Lipofuscinosis

(2012) Jennifer Greaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Modulation of Gating Property of G Protein-gated Inwardly Rectifying Potassium Ion Channel (GIRK) by i/o-family G Protein α Subunit (Gαi/o)

(2012) Yoko Mase et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

(2012) Alexander Adibekian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

(2012) Gelin Wang et al.   Nature Chemical Biology

GIRK channel modulation by assembly with allosterically regulated RGS proteins

(2012) H. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting protein lipidation in disease

(2012) Marilyn D. Resh   TRENDS IN MOLECULAR MEDICINE

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras

(2011) J. Xu et al.   BLOOD

Proteomic analysis of palmitoylated platelet proteins

(2011) L. Dowal et al.   BLOOD

Gi/oSignaling and the Palmitoyltransferase DHHC2 Regulate Palmitate Cycling and Shuttling of RGS7 Family-binding Protein

(2011) Lixia Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Profiling of S-acylated Macrophage Proteins Identifies a Role for Palmitoylation in Mitochondrial Targeting of Phospholipid Scramblase 3

(2011) B. Alex Merrick et al.   MOLECULAR & CELLULAR PROTEOMICS

Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

(2011) Fiona B. Young et al.   PROGRESS IN NEUROBIOLOGY

Small molecule inhibition of protein depalmitoylation as a new approach towards downregulation of oncogenic Ras signalling

(2010) Frank J. Dekker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling

(2010) Keqiang Xie et al.   NATURE NEUROSCIENCE

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Tandem fluorescence imaging of dynamic S-acylation and protein turnover

(2010) M. M. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95

(2009) Jun Noritake et al.   JOURNAL OF CELL BIOLOGY

The Influence of Neuroactive Steroid Lipophilicity on GABAA Receptor Modulation: Evidence for a Low-Affinity Interaction

(2009) Mariangela Chisari et al.   JOURNAL OF NEUROPHYSIOLOGY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein acyl thioesterases (Review)

(2009) Ruth Zeidman et al.   MOLECULAR MEMBRANE BIOLOGY

Large-scale profiling of protein palmitoylation in mammalian cells

(2009) Brent R Martin et al.   NATURE METHODS

Dynamic protein palmitoylation in cellular signaling

(2009) Tsuyoshi Iwanaga et al.   PROGRESS IN LIPID RESEARCH

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation

(2008) Rujun Kang et al.   NATURE

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling

(2008) Muralidharan Jayaraman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

(2007) D. Grabowska et al.   NEUROSCIENCE