Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Paclitaxel-in-liposome-in-bacteria for inhalation treatment of primary lung cancer

(2020) Mengmeng Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioengineered smart bacterial carriers for combinational targeted therapy of solid tumors

(2020) Siamak Alizadeh et al.   JOURNAL OF DRUG TARGETING

Colicin N Mediates Apoptosis and Suppresses Integrin-Modulated Survival in Human Lung Cancer Cells

(2020) Wanatchaporn Arunmanee et al.   MOLECULES

Use of a genetically engineered E. coli overexpressing β-glucuronidase accompanied by glycyrrhizic acid, a natural and anti-inflammatory agent, for directed treatment of colon carcinoma in a mouse model

(2020) Amin Afkhami-Poostchi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bacteria and cancer: Different sides of the same coin

(2020) Ghazaleh Laliani et al.   LIFE SCIENCES

Hypoxia-activated nanomedicines for effective cancer therapy

(2020) Mengjiao Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tumor Microenvironment Targeting Nano–Bio Emulsion for Synergistic Combinational X‐Ray PDT with Oncolytic Bacteria Therapy

(2020) Wooram Park et al.   Advanced Healthcare Materials

The DNA Damage Inducible SOS Response Is a Key Player in the Generation of Bacterial Persister Cells and Population Wide Tolerance

(2020) Zdravko Podlesek et al.   Frontiers in Microbiology

Antibacterial, anti-adherent and cytotoxic activities of surfactin(s) from a lipolytic strain Bacillus safensis F4

(2019) Faten Abdelli et al.   BIODEGRADATION

Bacterial l ‐asparaginases for cancer therapy: Current knowledge and future perspectives

(2019) Abdolmajid Ghasemian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nanoliposomal L-Asparaginase and Its Antitumor Activities in Lewis Lung Carcinoma Tumor-Induced BALB/c Mice

(2019) Thi Thao Do et al.   Advances in Materials Science and Engineering

Potential Role of Biofilm Formation in the Development of Digestive Tract Cancer With Special Reference to Helicobacter pylori Infection

(2019) Cosmeri Rizzato et al.   Frontiers in Microbiology

Therapeutic bacteria to combat cancer; current advances, challenges, and opportunities

(2019) Mansour Sedighi et al.   Cancer Medicine

Programmable bacteria as cancer therapy

(2019) Michael Dougan et al.   NATURE MEDICINE

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

(2019) Sreyan Chowdhury et al.   NATURE MEDICINE

Bacterial Biofilm Bioinspired Persistent Luminescence Nanoparticles with Gut-Oriented Drug Delivery for Colorectal Cancer Imaging and Chemotherapy

(2019) Zhi-Hao Wang et al.   ACS Applied Materials & Interfaces

Antimicrobial peptides as novel therapeutics for non-small cell lung cancer

(2019) Nitesh K. Kunda   DRUG DISCOVERY TODAY

Bacterial particles retard tumor growth as a novel vascular disrupting agent

(2019) Fengzhu Guo et al.   BIOMEDICINE & PHARMACOTHERAPY

Bacteria-cancer interactions: bacteria-based cancer therapy

(2019) Mai Thi-Quynh Duong et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

(2018) Wenfei Chen et al.   ACS Nano

A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic LeukemiasIn Vivo

(2018) Hien Anh Nguyen et al.   CANCER RESEARCH

A Randomized Phase 2 Study of ADXS11-001 Listeria monocytogenes–Listeriolysin O Immunotherapy With or Without Cisplatin in Treatment of Advanced Cervical Cancer

(2018) Partha Basu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Low dose chemotherapy combined with attenuated Salmonella decreases tumor burden and is less toxic than high dose chemotherapy in an autochthonous murine model of breast cancer

(2018) Daniel Saltzman et al.   SURGERY

Cell mass-dependent expression of an anticancer protein drug by tumor-targeted Salmonella

(2018) Kwangsoo Kim et al.   Oncotarget

Bacterial Therapy of Cancer: Promises, Limitations, and Insights for Future Directions

(2018) M. Gabriela Kramer et al.   Frontiers in Microbiology

The role of bacteria in cancer therapy – enemies in the past, but allies at present

(2018) Shiyu Song et al.   Infectious Agents and Cancer

Report on the NCI Microbial-Based Cancer Therapy Conference

(2018) Colleen S. Curran et al.   Cancer Immunology Research

Salmonella Immunotherapy Improves the Outcome of CHOP Chemotherapy in Non-Hodgkin Lymphoma-Bearing Mice

(2018) Thais Bascuas et al.   Frontiers in Immunology

Anticancer Activity of Bacterial Proteins and Peptides

(2018) Tomasz Karpiński et al.   Pharmaceutics

Engineered commensal microbes for diet-mediated colorectal-cancer chemoprevention

(2018) Chun Loong Ho et al.   Nature Biomedical Engineering

White paper on microbial anti-cancer therapy and prevention

(2018) Neil S. Forbes et al.   Journal for ImmunoTherapy of Cancer

Bacteriocins: perspective for the development of novel anticancer drugs

(2018) Piyush Baindara et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

(2018) Jasmine V.E. Chan-Hyams et al.   BIOCHEMICAL PHARMACOLOGY

Evaluation of anti-cancer, anti-microbial and anti-biofilm potential of biosurfactant extracted from an Acinetobacter M6 strain

(2018) Abraham Peele Karlapudi et al.   JOURNAL OF KING SAUD UNIVERSITY SCIENCE

Application of genetically engineered Salmonella typhimurium for interferon-gamma–induced therapy against melanoma

(2017) Wonsuck Yoon et al.   EUROPEAN JOURNAL OF CANCER

In pursuit of cancer metastasis therapy by bacteria and its biofilms: History or future

(2017) Mohd Adnan et al.   MEDICAL HYPOTHESES

The apoptotic impact of nisin as a potent bacteriocin on the colon cancer cells

(2017) Shiva Ahmadi et al.   MICROBIAL PATHOGENESIS

N-(3-oxododecanoyl)-L-homoserine lactone interactions in the breast tumor microenvironment: Implications for breast cancer viability and proliferation in vitro

(2017) Brittany N. Balhouse et al.   PLoS One

Two-step enhanced cancer immunotherapy with engineeredSalmonella typhimuriumsecreting heterologous flagellin

(2017) Jin Hai Zheng et al.   Science Translational Medicine

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

(2017) Oh Youn Kim et al.   Nature Communications

Anti-tumor activity of an immunotoxin (TGFα-PE38) delivered by attenuated Salmonella typhimurium

(2017) Daejin Lim et al.   Oncotarget

Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism

(2017) Jianxiang Chen et al.   Theranostics

Anticancer Activities of Surfactin and Potential Application of Nanotechnology Assisted Surfactin Delivery

(2017) Yuan-Seng Wu et al.   Frontiers in Pharmacology

Anticancer properties of a defensin like class IId bacteriocin Laterosporulin10

(2017) Piyush Baindara et al.   Scientific Reports

Spontaneous regression of tumour and the role of microbial infection – possibilities for cancer treatment

(2016) Petra Kucerova et al.   ANTI-CANCER DRUGS

Naturally Derived Iron Oxide Nanowires from Bacteria for Magnetically Triggered Drug Release and Cancer Hyperthermia in 2D and 3D Culture Environments: Bacteria Biofilm to Potent Cancer Therapeutic

(2016) Tushar Kumeria et al.   BIOMACROMOLECULES

Radiotherapy combined with an engineered Salmonella typhimurium inhibits tumor growth in a mouse model of colon cancer

(2016) Xiande Liu et al.   EXPERIMENTAL ANIMALS

Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

(2016) Romain Daillère et al.   IMMUNITY

Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria

(2016) Panos Lehouritis et al.   JOURNAL OF CONTROLLED RELEASE

Biosurfactants Produced by Marine Microorganisms with Therapeutic Applications

(2016) Eduardo Gudiña et al.   Marine Drugs

The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation

(2016) Julie Groizeleau et al.   MICROBIOLOGY-SGM

Combined antitumor activity of the nitroreductase/CB1954 suicide gene system and γ-rays in HeLa cells in vitro

(2016) Geling Teng et al.   Molecular Medicine Reports

Branched Gold Nanoparticle Coating ofClostridium novyi-NT Spores for CT-Guided Intratumoral Injection

(2016) Wooram Park et al.   Small

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

(2016) Seung-Hwan Park et al.   Theranostics

Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice

(2016) Lei Shi et al.   AMB Express

Arginine deprivation by arginine deiminase ofStreptococcus pyogenescontrols primary glioblastoma growthin vitroandin vivo

(2015) Tomas Fiedler et al.   CANCER BIOLOGY & THERAPY

Magnetic nanoparticle hyperthermia induced cytosine deaminase expression in microencapsulated E. coli for enzyme–prodrug therapy

(2015) Krishnamurthy V. Nemani et al.   JOURNAL OF BIOTECHNOLOGY

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Crosstalk between the microbiome and cancer cells by quorum sensing peptides

(2015) Evelien Wynendaele et al.   PEPTIDES

The Quorum Sensing Peptides PhrG, CSP and EDF Promote Angiogenesis and Invasion of Breast Cancer Cells In Vitro

(2015) Bart De Spiegeleer et al.   PLoS One

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

(2015) Verena Staedtke et al.   Oncotarget

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice

(2015) Yasunori Matsumoto et al.   Oncotarget

Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β

(2015) Jung-Eun Kim et al.   Theranostics

Bacteriocins as Potential Anticancer Agents

(2015) Sumanpreet Kaur et al.   Frontiers in Pharmacology

Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice

(2015) Wamidh H. Talib et al.   PLoS One

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models

(2015) Yukihiko Hiroshima et al.   Oncotarget

Gene-Directed Enzyme Prodrug Therapy

(2014) Jin Zhang et al.   AAPS Journal

Highly Active Electrocatalysis of the Hydrogen Evolution Reaction by Cobalt Phosphide Nanoparticles

(2014) Eric J. Popczun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor-Specific Delivery of Histidine-Rich Glycoprotein Suppresses Tumor Growth and Metastasis by Anti-angiogenesis and Vessel Normalization

(2014) Xiawei Cheng et al.   CURRENT GENE THERAPY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Antiangiogenic Activity of the Lipophilic Antimicrobial Peptides from an Endophytic Bacterial Strain Isolated from Red Pepper Leaf

(2014) Hye Jin Jung et al.   MOLECULES AND CELLS

Bacterial Quorum Sensing Molecule N-3-Oxo-Dodecanoyl-L-Homoserine Lactone Causes Direct Cytotoxicity and Reduced Cell Motility in Human Pancreatic Carcinoma Cells

(2014) Ashwath S. Kumar et al.   PLoS One

A commercially available preparation ofStaphylococcus aureusbio-products potently inhibits tumour growth in a murine model of mesothelioma

(2014) Sally M. Lansley et al.   RESPIROLOGY

Effects of biosurfactants on the viability and proliferation of human breast cancer cells

(2014) Cristina Duarte et al.   AMB Express

Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line

(2013) Cindy Bandala et al.   Asian Pacific Journal of Cancer Prevention

Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

(2013) P. E. Massa et al.   BLOOD

Bacterial-directed enzyme prodrug therapy

(2013) Panos Lehouritis et al.   JOURNAL OF CONTROLLED RELEASE

Engineering Escherichia coli for Light-Activated Cytolysis of Mammalian Cells

(2013) Michael S. Magaraci et al.   ACS Synthetic Biology

Bacteria and tumours: causative agents or opportunistic inhabitants?

(2013) Joanne Cummins et al.   Infectious Agents and Cancer

Surfactin suppresses TPA-induced breast cancer cell invasion through the inhibition of MMP-9 expression

(2012) SUN YOUNG PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The potential role of quorum-sensing peptides in oncology

(2012) E. Wynendaele et al.   MEDICAL HYPOTHESES

Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity

(2012) A. D. Paiva et al.   MICROBIOLOGY-SGM

Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model

(2011) Jianxiang Chen et al.   CANCER SCIENCE

Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy

(2011) R Gardlik et al.   GENE THERAPY

Palmitoylation State Impacts Induction of Innate and Acquired Immunity by the Salmonella enterica Serovar TyphimuriummsbBMutant

(2011) Qingke Kong et al.   INFECTION AND IMMUNITY

Aerosolized BC-819 Inhibits Primary but Not Secondary Lung Cancer Growth

(2011) Günther Hasenpusch et al.   PLoS One

Antitumor therapeutic effects of a genetically engineered Salmonella typhimurium harboring TNF-α in mice

(2010) Won Suck Yoon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli –mediated Cytolytic Therapy and Radiotherapy

(2010) Sheng-Nan Jiang et al.   MOLECULAR THERAPY

Use of H19 Gene Regulatory Sequences in DNA-Based Therapy for Pancreatic Cancer

(2010) V. Scaiewicz et al.   Journal of Oncology

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

(2009) S Ganai et al.   BRITISH JOURNAL OF CANCER

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

(2009) R M Ryan et al.   GENE THERAPY

Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences

(2009) Aya Mizrahi et al.   Journal of Translational Medicine

Development of a Listeria monocytogenes based vaccine against prostate cancer

(2008) Vafa Shahabi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibition of Tumor Growth Using Salmonella Expressing Fas Ligand

(2008) Markus Loeffler et al.   JNCI-Journal of the National Cancer Institute

Bacteria form biofilms against cancer metastasis

(2008) Tao Weitao   MEDICAL HYPOTHESES