Bacteria-cancer interactions: bacteria-based cancer therapy

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth

(2019) Thuy Phan et al.   CANCER GENE THERAPY

Genetically engineered Salmonella Typhimurium: Recent advances in cancer therapy

(2019) Kang Liang et al.   CANCER LETTERS

Endostatin gene therapy delivered by attenuated Salmonella typhimurium in murine tumor models

(2018) Kang Liang et al.   CANCER GENE THERAPY

A Randomized Phase 2 Study of ADXS11-001 Listeria monocytogenes–Listeriolysin O Immunotherapy With or Without Cisplatin in Treatment of Advanced Cervical Cancer

(2018) Partha Basu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

E. coli Nissle 1917-Derived Minicells for Targeted Delivery of Chemotherapeutic Drug to Hypoxic Regions for Cancer Therapy

(2018) Yunlei Zhang et al.   Theranostics

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

(2018) Friedrich H. Schmitz-Winnenthal et al.   OncoImmunology

Attenuated Salmonella Typhimurium Carrying TRAIL and VP3 Genes Inhibits the Growth of Gastric Cancer Cells in Vitro and in Vivo

(2018) Hong-Dan Cao et al.   TUMORI

Synthetic Biology and Engineered Live Biotherapeutics: Toward Increasing System Complexity

(2018) Tanel Ozdemir et al.   Cell Systems

Smart Bacterial Magnetic Nanoparticles for Tumor-Targeting Magnetic Resonance Imaging of HER2-Positive Breast Cancers

(2018) Yunlei Zhang et al.   ACS Applied Materials & Interfaces

Application of genetically engineered Salmonella typhimurium for interferon-gamma–induced therapy against melanoma

(2017) Wonsuck Yoon et al.   EUROPEAN JOURNAL OF CANCER

The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43

(2017) Han-Chen Lin et al.   International Journal of Medical Sciences

Nanocarriers for TRAIL delivery: driving TRAIL back on track for cancer therapy

(2017) Xu Wu et al.   Nanoscale

32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect

(2017) Dinesh Chandra et al.   Oncotarget

Engineered Salmonella enterica serovar Typhimurium overcomes limitations of anti-bacterial immunity in bacteria-mediated tumor therapy

(2017) Sebastian Felgner et al.   OncoImmunology

Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses

(2016) Jan T. Panteli et al.   BIOTECHNOLOGY AND BIOENGINEERING

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

Synchronized cycles of bacterial lysis for in vivo delivery

(2016) M. Omar Din et al.   NATURE

aroA -Deficient Salmonella enterica Serovar Typhimurium Is More Than a Metabolically Attenuated Mutant

(2016) Sebastian Felgner et al.   mBio

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

(2016) Seung-Hwan Park et al.   Theranostics

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Trg-deficient Salmonella colonize quiescent tumor regions by exclusively penetrating or proliferating

(2015) Miaomin Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Activation of inflammasome by attenuatedSalmonella typhimuriumin bacteria-mediated cancer therapy

(2015) Thuy Xuan Phan et al.   MICROBIOLOGY AND IMMUNOLOGY

Recombinant Salmonella-based CEACAM6 and 4-1BBL vaccine enhances T-cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL and CEACAM6

(2015) CHUNHUI JIN et al.   ONCOLOGY REPORTS

Quorum-sensingSalmonellaselectively trigger protein expression within tumors

(2015) Charles A. Swofford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficiency of Conditionally Attenuated Salmonella enterica Serovar Typhimurium in Bacterium-Mediated Tumor Therapy

(2015) Michael Frahm et al.   mBio

Attenuated mutant strain of Salmonella Typhimurium lacking the ZnuABC transporter contrasts tumor growth promoting anti-cancer immune response

(2015) Barbara Chirullo et al.   Oncotarget

Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β

(2015) Jung-Eun Kim et al.   Theranostics

Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors

(2015) E. R. Manuel et al.   Cancer Immunology Research

ASalmonellaTyphimurium mutant strain capable of RNAi delivery

(2014) Xiawei Cheng et al.   CANCER BIOLOGY & THERAPY

Targeted deletion of thearaoperon ofSalmonella typhimuriumenhances L-arabinose accumulation and drives PBAD-promoted expression of anti-cancer toxins and imaging agents

(2014) Hyun Hong et al.   CELL CYCLE

Salmonella induce autophagy in melanoma by the downregulation of AKT/mTOR pathway

(2014) C-H Lee et al.   GENE THERAPY

In Vivo IFN-γ Secretion by NK Cells in Response to Salmonella Typhimurium Requires NLRC4 Inflammasomes

(2014) Andreas Kupz et al.   PLoS One

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses

(2014) N. J. Roberts et al.   Science Translational Medicine

Programming Controlled Adhesion of E. coli to Target Surfaces, Cells, and Tumors with Synthetic Adhesins

(2014) Carlos Piñero-Lambea et al.   ACS Synthetic Biology

Improved cytotoxic effects ofSalmonella-producing cytosine deaminase in tumour cells

(2014) Beatriz Mesa-Pereira et al.   Microbial Biotechnology

Engineered Salmonella typhimurium expressing E7 fusion protein, derived from human papillomavirus, inhibits tumor growth in cervical tumor-bearing mice

(2013) Wonsuck Yoon et al.   BIOTECHNOLOGY LETTERS

Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice

(2013) D Chandra et al.   BRITISH JOURNAL OF CANCER

Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma

(2013) Elisa Berger et al.   CANCER LETTERS

Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation

(2013) Wen-Wei Chang et al.   INTERNATIONAL JOURNAL OF CANCER

Salmonella typhimurium Mediated Delivery of Apoptin in Human Laryngeal Cancer

(2013) Guo-fang Guan et al.   International Journal of Medical Sciences

Clostridium butyricum MIYAIRI 588 shows antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8

(2013) MASAHIDE SHINNOH et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Engineering of Bacteria for the Visualization of Targeted Delivery of a Cytolytic Anticancer Agent

(2013) Sheng-Nan Jiang et al.   MOLECULAR THERAPY

Nontoxic radioactive Listeriaat is a highly effective therapy against metastatic pancreatic cancer

(2013) W. Quispe-Tintaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction of an inducible cell-communication system that amplifiesSalmonellagene expression in tumor tissue

(2012) Yumei Dai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antitumor effects of Stat3-siRNA and endostatin combined therapies, delivered by attenuated Salmonella, on orthotopically implanted hepatocarcinoma

(2012) Huijie Jia et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Combined immunotherapy with Listeria monocytogenes-based PSA vaccine and radiation therapy leads to a therapeutic response in a murine model of prostate cancer

(2012) Raquibul Hannan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Systemic Delivery of Salmonella typhimurium Transformed with IDO shRNA Enhances Intratumoral Vector Colonization and Suppresses Tumor Growth

(2012) C. A. Blache et al.   CANCER RESEARCH

Phosphate Groups of Lipid A Are Essential for Salmonella enterica Serovar Typhimurium Virulence and Affect Innate and Adaptive Immunity

(2012) Qingke Kong et al.   INFECTION AND IMMUNITY

CD8 T-Cell Induction against Vascular Endothelial Growth Factor Receptor 2 by Salmonella for Vaccination Purposes against a Murine Melanoma

(2012) Stefan Jellbauer et al.   PLoS One

A Bioluminescent Transposon Reporter-Trap Identifies Tumor-Specific Microenvironment-Induced Promoters in Salmonella for Conditional Bacterial-Based Tumor Therapy

(2012) Kelly Flentie et al.   Cancer Discovery

Tumor-Associated Antigen Expressing Listeria monocytogenes Induces Effective Primary and Memory T-Cell Responses Against Hepatic Colorectal Cancer Metastases

(2011) Kelly Olino et al.   ANNALS OF SURGICAL ONCOLOGY

In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis

(2011) S Ganai et al.   CANCER GENE THERAPY

Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105

(2011) Laurence M. Wood et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhancement of Cancer Vaccine Therapy by Systemic Delivery of a Tumor-Targeting Salmonella-Based STAT3 shRNA Suppresses the Growth of Established Melanoma Tumors

(2011) E. R. Manuel et al.   CANCER RESEARCH

Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth

(2011) Z. Cai et al.   CANCER RESEARCH

Palmitoylation State Impacts Induction of Innate and Acquired Immunity by the Salmonella enterica Serovar TyphimuriummsbBMutant

(2011) Qingke Kong et al.   INFECTION AND IMMUNITY

Motility is critical for effective distribution and accumulation of bacteria in tumor tissue

(2011) Bhushan J. Toley et al.   Integrative Biology

Induction of Effective Antitumor Response After Mucosal Bacterial Vector Mediated DNA Vaccination With Endogenous Prostate Cancer Specific Antigen

(2011) Sarfraz Ahmad et al.   JOURNAL OF UROLOGY

Engineering and Visualization of Bacteria for Targeting Infarcted Myocardium

(2011) Uyenchi N Le et al.   MOLECULAR THERAPY

Development of a Listeria monocytogenes-based vaccine against hepatocellular carcinoma

(2011) Y Chen et al.   ONCOGENE

Antitumor therapeutic effects of a genetically engineered Salmonella typhimurium harboring TNF-α in mice

(2010) Won Suck Yoon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Orally Administered DNA Vaccine Delivery by Attenuated Salmonella typhimurium Targeting Fetal Liver Kinase 1 Inhibits Murine Lewis Lung Carcinoma Growth and Metastasis

(2010) Shu Guang Zuo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Tumor-targeted delivery of biologically active TRAIL protein

(2010) H-Y Zhang et al.   CANCER GENE THERAPY

Oral Vaccination with Attenuated Salmonella enterica Strains Encoding T-Cell Epitopes from Tumor Antigen NY-ESO-1 Induces Specific Cytotoxic T-Lymphocyte Responses

(2010) J.-Z. Meng et al.   Clinical and Vaccine Immunology

Translating Tumor Antigens into Cancer Vaccines

(2010) Luigi Buonaguro et al.   Clinical and Vaccine Immunology

Enterobacterial tumor colonization in mice depends on bacterial metabolism and macrophages but is independent of chemotaxis and motility

(2010) Jochen Stritzker et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli –mediated Cytolytic Therapy and Radiotherapy

(2010) Sheng-Nan Jiang et al.   MOLECULAR THERAPY

Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity

(2010) F. Saccheri et al.   Science Translational Medicine

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

(2009) S Ganai et al.   BRITISH JOURNAL OF CANCER

High Efficacy of a Listeria-Based Vaccine against Metastatic Breast Cancer Reveals a Dual Mode of Action

(2009) S. H. Kim et al.   CANCER RESEARCH

Genetically Engineered Salmonella typhimurium as an Imageable Therapeutic Probe for Cancer

(2009) V. H. Nguyen et al.   CANCER RESEARCH

Targeted therapy of spinal cord glioma with a genetically modifiedSalmonella typhimurium

(2009) H. Kimura et al.   CELL PROLIFERATION

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

(2009) R M Ryan et al.   GENE THERAPY

Cancer metastasis directly eradicated by targeted therapy with a modifiedSalmonella typhimurium

(2009) Katsuhiro Hayashi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A novel Bifidobacterium infantis-mediated TK/GCV suicide gene therapy system exhibits antitumor activity in a rat model of bladder cancer

(2009) Wei Tang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α

(2009) Sara Leschner et al.   PLoS One

Tumor-targeting prodrug-activating bacteria for cancer therapy

(2008) C-M Cheng et al.   CANCER GENE THERAPY

Development of a Listeria monocytogenes based vaccine against prostate cancer

(2008) Vafa Shahabi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Salmonella typhimurium engineered to produce CCL21 inhibit tumor growth

(2008) Markus Loeffler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Salmonella Promoters Preferentially Activated Inside Tumors

(2008) N. Arrach et al.   CANCER RESEARCH

Containment of Tumor-Colonizing Bacteria by Host Neutrophils

(2008) K. Westphal et al.   CANCER RESEARCH

Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment

(2008) Stephanie Weibel et al.   CELLULAR MICROBIOLOGY

Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy

(2008) F. Friedlos et al.   CLINICAL CANCER RESEARCH

Potent anti-tumor activity of systemically-administered IL2-expressing Salmonella correlates with decreased angiogenesis and enhanced tumor apoptosis

(2008) Basel K. al-Ramadi et al.   CLINICAL IMMUNOLOGY

Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma

(2008) Brent S. Sorenson et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH