The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

ECSASB2 mediates MLL degradation during hematopoietic differentiation

(2011) J. Wang et al.   BLOOD

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation

(2011) Ji-Yao Li et al.   BMC NEUROSCIENCE

A Mechanism Underlying NOTCH-Induced and Ubiquitin-mediated JAK3 Degradation

(2011) Wei Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Inducible Nitric-oxide Synthase by the SPRY Domain- and SOCS Box-containing Proteins

(2011) Tadashi Nishiya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 ubiquitin ligase specificity subunit ASB2  targets filamins for proteasomal degradation by interacting with the filamin actin-binding domain

(2011) Z. Razinia et al.   JOURNAL OF CELL SCIENCE

TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction

(2011) R. S. Lewis et al.   JOURNAL OF IMMUNOLOGY

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

(2011) Mattias Vesterlund et al.   PLoS One

ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function

(2010) Sanghoon Kwon et al.   BMC BIOLOGY

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes

(2010) Lei Nie et al.   CELL RESEARCH

Deubiquitinases in the regulation of NF-κB signaling

(2010) Edward W Harhaj et al.   CELL RESEARCH

Structural assembly of cullin-RING ubiquitin ligase complexes

(2010) Erik S Zimmerman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

(2010) Fahad Zadjali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SPRY domain–containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

(2010) Zhihe Kuang et al.   JOURNAL OF CELL BIOLOGY

Suppressor of Cytokine Signaling 2 Regulates IL-15-Primed Human NK Cell Function via Control of Phosphorylated Pyk2

(2010) S. H. Lee et al.   JOURNAL OF IMMUNOLOGY

Regulation of Drosophila Vasa In Vivo through Paralogous Cullin-RING E3 Ligase Specificity Receptors

(2010) J.-M. Kugler et al.   MOLECULAR AND CELLULAR BIOLOGY

Essential Role for the d-Asb11 cul5 Box Domain for Proper Notch Signaling and Neural Cell Fate Decisions In Vivo

(2010) Maria A. Sartori da Silva et al.   PLoS One

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

The E3 ubiquitin ligase specificity subunit ASB2β is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation

(2009) N F Bello et al.   CELL DEATH AND DIFFERENTIATION

Expression of Ankyrin Repeat and Suppressor of Cytokine Signaling Box Protein 4 (Asb-4) in Proopiomelanocortin Neurons of the Arcuate Nucleus of Mice Produces a Hyperphagic, Lean Phenotype

(2009) Ji-Yao Li et al.   ENDOCRINOLOGY

SOCS-6 Negatively Regulates T Cell Activation through Targeting p56lckto Proteasomal Degradation

(2009) Young Bong Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

(2009) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific Ubiquitination Determines Lysosomal Sorting and Signal Attenuation of the Granulocyte Colony-Stimulating Factor Receptor

(2009) Albert Wölfler et al.   TRAFFIC

ASB2 targets filamins A and B to proteasomal degradation

(2008) M. L. Heuze et al.   BLOOD

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

(2008) Kristy Boyle et al.   CELLULAR SIGNALLING

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

(2008) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY

d-Asb11 is an essential mediator of canonical Delta–Notch signalling

(2008) Sander H. Diks et al.   NATURE CELL BIOLOGY

SOCS regulation of the JAK/STAT signalling pathway

(2008) Ben A. Croker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY