The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition
Authors
Keywords
-
Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 18, Pages 6627
Publisher
MDPI AG
Online
2020-09-10
DOI
10.3390/ijms21186627
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Diabetes: Is there a future for Pharmacogenomics guided treatment?
- (2019) Ewan R Pearson CLINICAL PHARMACOLOGY & THERAPEUTICS
- Pharmacogenomics of Cisplatin‐Induced Ototoxicity: Successes, Shortcomings and Future Avenues of Research
- (2019) Britt I. Drögemöller et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Kidney cortical transporter expression across species using quantitative proteomics
- (2019) Abdul Basit et al. DRUG METABOLISM AND DISPOSITION
- Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients
- (2019) Zazuli et al. Genes
- Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy
- (2019) Matthew R Trendowski et al. CLINICAL CANCER RESEARCH
- Metformin: time to review its role and safety in chronic kidney disease
- (2019) Cara Tanner et al. MEDICAL JOURNAL OF AUSTRALIA
- Pharmacogenomics
- (2019) Dan M Roden et al. LANCET
- rs622342A>C in SLC22A1 is associated with metformin pharmacokinetics and glycemic response
- (2019) Khaled Naja et al. Drug Metabolism and Pharmacokinetics
- Effects of Single Nucleotide Polymorphism Ala270Ser (rs316019) on the Function and Regulation of hOCT2
- (2019) Frenzel et al. Biomolecules
- Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort
- (2018) Ana Beatriz Santoro et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Evaluation of rs3088442 G > A SLC22A3 Gene Polymorphism and Role of microRNA 147 in T2DM Groups of Adult Pakistani Population in Response to Metformin
- (2018) Sadaf Moeez et al. Canadian Journal of Diabetes
- Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective From the International Transporter Consortium
- (2018) Sook Wah Yee et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Genetic Variants inCPA6andPRPF31Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes
- (2018) Daniel M. Rotroff et al. DIABETES
- Organic cation transporter 3: A cellular mechanism underlying rapid, non-genomic glucocorticoid regulation of monoaminergic neurotransmission, physiology, and behavior
- (2018) Paul J. Gasser et al. HORMONES AND BEHAVIOR
- Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes
- (2018) Edith Pascale Mofo Mato et al. MEDICINE
- Cisplatin-induced nephrotoxicity in patients with advanced neuroblastoma
- (2018) Ryu Yanagisawa et al. PEDIATRIC BLOOD & CANCER
- Association between genetic polymorphisms and platinum-induced ototoxicity in children
- (2018) Gabrielle Lui et al. Oncotarget
- Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review
- (2018) Zulfan Zazuli et al. Frontiers in Pharmacology
- Biomarkers of drug-induced kidney toxicity
- (2018) Benjamin R. Griffin et al. THERAPEUTIC DRUG MONITORING
- Predictors of cisplatin-induced ototoxicity and survival in chemoradiation treated head and neck cancer patients
- (2018) Wendy A. Teft et al. ORAL ONCOLOGY
- Pharmacogenomic Variants May Influence the Urinary Excretion of Novel Kidney Injury Biomarkers in Patients Receiving Cisplatin
- (2017) Cara Chang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cisplatin nephrotoxicity: a review of the literature
- (2017) Sandhya Manohar et al. JOURNAL OF NEPHROLOGY
- TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity
- (2017) Signe Thiesen et al. Pharmacogenetics and Genomics
- OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children
- (2017) Rajiv Balyan et al. PHARMACOGENOMICS
- Imatinib-induced ophthalmological side-effects in GIST patients are associated with the variations of EGFR, SLC22A1, SLC22A5 and ABCB1
- (2017) H-B Qiu et al. PHARMACOGENOMICS JOURNAL
- Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer
- (2017) Britt I. Drögemöller et al. JAMA Oncology
- A decade of human genome project conclusion: Scientific diffusion about our genome knowledge
- (2016) Fernanda Moraes et al. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
- Variants inWFS1and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity
- (2016) Heather E. Wheeler et al. CLINICAL CANCER RESEARCH
- A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin
- (2016) S Goswami et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients
- (2016) Linda Zaharenko et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
- (2016) Kaixin Zhou et al. NATURE GENETICS
- Polyspecific organic cation transporters and their impact on drug intracellular levels and pharmacodynamics
- (2016) David J. Wagner et al. PHARMACOLOGICAL RESEARCH
- The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin
- (2016) Emil Andreev et al. Scientific Reports
- The variant organic cation transporter 2 (OCT2)–T201M contribute to changes in insulin resistance in patients with type 2 diabetes treated with metformin
- (2015) Zahra Kashi et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial
- (2015) Mette Marie H. Christensen et al. DIABETOLOGIA
- Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers
- (2015) Mette Marie Hougaard Christensen et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Role of organic cation transporters in drug–drug interaction
- (2015) Hermann Koepsell Expert Opinion on Drug Metabolism & Toxicology
- Epigenetics of Aging and Alzheimer’s Disease: Implications for Pharmacogenomics and Drug Response
- (2015) Ramón Cacabelos et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
- (2015) Heng Xu et al. NATURE GENETICS
- Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses and drug–drug interactions
- (2015) C Arimany-Nardi et al. PHARMACOGENOMICS JOURNAL
- Influence of Genetic Variants in TPMT and COMT Associated with Cisplatin Induced Hearing Loss in Patients with Cancer: Two New Cohorts and a Meta-Analysis Reveal Significant Heterogeneity between Cohorts
- (2015) Melanie M. Hagleitner et al. PLoS One
- Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study
- (2014) Tanja Dujic et al. DIABETES
- Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
- (2014) Clifford Jacobs et al. GENETICS AND MOLECULAR BIOLOGY
- Differing Effects of Metformin on Glycemic Control by Race-Ethnicity
- (2014) L. Keoki Williams et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- ABCC3 and OCT1 genotypes influence pharmacokinetics of morphine in children
- (2014) Raja Venkatasubramanian et al. PHARMACOGENOMICS
- Organic Cation Transporter OCTs (SLC22) and MATEs (SLC47) in the Human Kidney
- (2013) Hideyuki Motohashi et al. AAPS Journal
- Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration
- (2013) Mladen V. Tzvetkov et al. BIOCHEMICAL PHARMACOLOGY
- The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin-Induced Ototoxicity in Children With Cancer
- (2013) J J Yang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Absence of effect ofSLC22A2genotype on cisplatin-induced nephrotoxicity in oesophageal cancer patients receiving cisplatin and 5-fluorouracil: report of results discordant with those of earlier studies
- (2013) Y. Hinai et al. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Identification of Novel Substrates and Structure–Activity Relationship of Cellular Uptake Mediated by Human Organic Cation Transporters 1 and 2
- (2013) Ramon Hendrickx et al. JOURNAL OF MEDICINAL CHEMISTRY
- The SLC22 family with transporters of organic cations, anions and zwitterions
- (2013) Hermann Koepsell MOLECULAR ASPECTS OF MEDICINE
- Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake
- (2012) Min-Koo Choi et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events
- (2012) Kazufumi Iwata et al. Clinical and Experimental Nephrology
- Proximal Tubular Secretion of Creatinine by Organic Cation Transporter OCT2 in Cancer Patients
- (2012) G. Ciarimboli et al. CLINICAL CANCER RESEARCH
- Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients
- (2012) Jing Zhang et al. FOOD AND CHEMICAL TOXICOLOGY
- Metformin in patients with chronic kidney disease: strengths and weaknesses
- (2012) Ana Rocha et al. JOURNAL OF NEPHROLOGY
- Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients
- (2012) Linda Tarasova et al. Pharmacogenetics and Genomics
- Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3
- (2012) L Chen et al. PHARMACOGENOMICS JOURNAL
- SLC22A1-ABCB1 Haplotype Profiles Predict Imatinib Pharmacokinetics in Asian Patients with Chronic Myeloid Leukemia
- (2012) Onkar Singh et al. PLoS One
- Effects of OCT2 c.602C > T genetic variant on the pharmacokinetics of lamivudine
- (2012) Chang-Ik Choi et al. XENOBIOTICA
- Clinical Pharmacokinetics of Metformin
- (2011) Garry G. Graham et al. CLINICAL PHARMACOKINETICS
- Screening of genetic variations of SLC15A2, SLC22A1, SLC22A2 and SLC22A6 genes
- (2011) Hyun Sub Cheong et al. JOURNAL OF HUMAN GENETICS
- The pharmacogenetics of metformin and its impact on plasma metformin steady-state levels and glycosylated hemoglobin A1c
- (2011) Mette M.H. Christensen et al. Pharmacogenetics and Genomics
- Organic Cation Transporter 2 Mediates Cisplatin-Induced Oto- and Nephrotoxicity and Is a Target for Protective Interventions
- (2010) Giuliano Ciarimboli et al. AMERICAN JOURNAL OF PATHOLOGY
- Association of theSLC22A1,SLC22A2, andSLC22A3genes encoding organic cation transporters with diabetic nephropathy and hypertension
- (2010) Riitta Sallinen et al. ANNALS OF MEDICINE
- Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program
- (2010) K. A. Jablonski et al. DIABETES
- Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
- (2010) Takeshi Sakata et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Genetic Polymorphisms in Organic Cation Transporter 1 (OCT1) in Chinese and Japanese Populations Exhibit Altered Function
- (2010) L. Chen et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
- (2010) Zhi-Jun Wang et al. Pharmacogenetics and Genomics
- Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin
- (2010) Ligong Chen et al. Pharmacogenetics and Genomics
- Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
- (2009) K K Filipski et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The Effects of Genetic Polymorphisms in the Organic Cation Transporters OCT1, OCT2, and OCT3 on the Renal Clearance of Metformin
- (2009) M V Tzvetkov et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- The Pharmacogenomics of Membrane Transporters Project: Research at the Interface of Genomics and Transporter Pharmacology
- (2009) D L Kroetz et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
- (2009) Anne T. Nies et al. HEPATOLOGY
- Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
- (2009) Colin J D Ross et al. NATURE GENETICS
- Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin
- (2009) Ying Chen et al. Pharmacogenetics and Genomics
- Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus
- (2009) M L Becker et al. PHARMACOGENOMICS JOURNAL
- Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
- (2008) IS Song et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Organic cation transporters
- (2008) G. Ciarimboli XENOBIOTICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More