Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration
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Title
Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 18, Pages 6575
Publisher
MDPI AG
Online
2020-09-08
DOI
10.3390/ijms21186575
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Note: Only part of the references are listed.- Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson’s disease
- (2020) Yaping Chu et al. BRAIN
- Small-molecule agonists of the RET receptor tyrosine kinase activate biased trophic signals that are influenced by the presence of GFRa1 co-receptors
- (2020) Sean Jmaeff et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2020) Sean Jmaeff et al. MOLECULAR PHARMACOLOGY
- Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson’s disease
- (2020) Arun Kumar Mahato et al. CELL AND TISSUE RESEARCH
- Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice
- (2020) Giorgio Turconi et al. Molecular Therapy-Methods & Clinical Development
- Artemin and an Artemin-Derived Peptide, Artefin, Induce Neuronal Survival, and Differentiation Through Ret and NCAM
- (2019) Mirolyuba Ilieva et al. Frontiers in Molecular Neuroscience
- Extended Treatment with Glial Cell Line-Derived Neurotrophic Factor in Parkinson’s Disease
- (2019) Alan L. Whone et al. Journal of Parkinsons Disease
- Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease
- (2019) Alan Whone et al. BRAIN
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders
- (2019) Leonardo Guzman-Martinez et al. Frontiers in Pharmacology
- Glial cell line–derived neurotrophic factor receptor Rearranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo
- (2019) Arun Kumar Mahato et al. MOVEMENT DISORDERS
- ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
- (2019) Rita Mejzini et al. Frontiers in Neuroscience
- GDNF and alcohol use disorder
- (2018) Segev Barak et al. ADDICTION BIOLOGY
- Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
- (2018) Ru-Rong Ji et al. ANESTHESIOLOGY
- Respiratory Failure in Amyotrophic Lateral Sclerosis
- (2018) Shannon Niedermeyer et al. CHEST
- Differential Spinal and Supraspinal Activation of Glia in a Rat Model of Morphine Tolerance
- (2018) Viljami Jokinen et al. NEUROSCIENCE
- Neuroregeneration in Parkinson’s Disease: From Proteins to Small Molecules
- (2018) Yulia A. Sidorova et al. Current Neuropharmacology
- Stem cell transplantation for amyotrophic lateral sclerosis
- (2018) Robert H. Baloh et al. CURRENT OPINION IN NEUROLOGY
- GDF15 and Growth Control
- (2018) Paul J. Emmerson et al. Frontiers in Physiology
- Systemic injection of AAV9-GDNF provides modest functional improvements in the SOD1G93A ALS rat but has adverse side effects
- (2017) G M Thomsen et al. GENE THERAPY
- Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles
- (2017) Marta Machado-Pereira et al. MEDIATORS OF INFLAMMATION
- Obesity: Receptors identified for a weight regulator
- (2017) Mart Saarma et al. NATURE
- Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
- (2017) Jer-Yuan Hsu et al. NATURE
- GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
- (2017) Linda Yang et al. NATURE MEDICINE
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates
- (2017) Shannon E Mullican et al. NATURE MEDICINE
- The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL
- (2017) Paul J Emmerson et al. NATURE MEDICINE
- α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
- (2017) Yvette C Wong et al. NATURE MEDICINE
- Safety and efficacy of neublastin in painful lumbosacral radiculopathy
- (2017) Miroslav Backonja et al. PAIN
- Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys
- (2017) Yumei Xiong et al. Science Translational Medicine
- A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat
- (2017) Yulia A. Sidorova Frontiers in Pharmacology
- Anti-inflammatory Microglia/Macrophages As a Potential Therapeutic Target in Brain Metastasis
- (2017) Kleopatra E. Andreou et al. Frontiers in Oncology
- Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica
- (2016) Pieter Okkerse et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The GDNF-GFRα1 complex promotes the development of hippocampal dendritic arbors and spines via NCAM
- (2016) Dolores Irala et al. DEVELOPMENT
- Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease
- (2016) Pia Runeberg-Roos et al. NEUROBIOLOGY OF DISEASE
- Non-motor symptoms in Parkinson's disease
- (2016) Ronald F. Pfeiffer PARKINSONISM & RELATED DISORDERS
- Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3
- (2016) Erika K. Lippoldt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial
- (2015) C. Warren Olanow et al. ANNALS OF NEUROLOGY
- Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease
- (2015) Mallory J. Stenslik et al. JOURNAL OF NEUROSCIENCE METHODS
- First-In-Human, Double-Blind, Placebo-Controlled, Randomized, Dose-Escalation Study of BG00010, a Glial Cell Line-Derived Neurotrophic Factor Family Member, in Subjects with Unilateral Sciatica
- (2015) Paul E. Rolan et al. PLoS One
- Mechanisms of RET signaling in cancer: Current and future implications for targeted therapy
- (2014) I. Plaza-Menacho et al. CELLULAR SIGNALLING
- Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells
- (2014) Susana Revilla et al. CNS Neuroscience & Therapeutics
- The Anorectic Actions of the TGFβ Cytokine MIC-1/GDF15 Require an Intact Brainstem Area Postrema and Nucleus of the Solitary Tract
- (2014) Vicky Wang-Wei Tsai et al. PLoS One
- Augmenting glial cell-line derived neurotrophic factor signaling to treat painful neuropathies
- (2014) Ahmet Höke PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling
- (2014) Kristian L. Hedstrom et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2013) Jeffrey H. Kordower et al. BRAIN
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- Artemin induced functional recovery and reinnervation after partial nerve injury
- (2013) Ruizhong Wang et al. PAIN
- Axon degeneration in Parkinson's disease
- (2012) Robert E. Burke et al. EXPERIMENTAL NEUROLOGY
- Involvement of phospholipase C-γ in the pro-survival role of glial cell line-derived neurotrophic factor in developing motoneurons in rat spinal cords
- (2012) RAO FU et al. Molecular Medicine Reports
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- (2012) Laurence Macia et al. PLoS One
- Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose
- (2011) E Touchard et al. GENE THERAPY
- Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin
- (2011) Maxim M. Bespalov et al. JOURNAL OF CELL BIOLOGY
- Quantitative Automated Microscopy (QuAM) Elucidates Growth Factor Specific Signalling in Pain Sensitization
- (2011) Christine Andres et al. Molecular Pain
- AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa
- (2011) Deniz Dalkara et al. MOLECULAR THERAPY
- Clinical progression in Parkinson disease and the neurobiology of axons
- (2010) Hsiao-Chun Cheng et al. ANNALS OF NEUROLOGY
- Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
- (2010) William J Marks et al. LANCET NEUROLOGY
- Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease
- (2010) Yulia A. Sidorova et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Dopamine Neuron Stimulating Actions of a GDNF Propeptide
- (2010) Luke H. Bradley et al. PLoS One
- Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons
- (2009) Marjo Piltonen et al. EXPERIMENTAL NEUROLOGY
- Role of Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Neural Cell Adhesion Molecule (NCAM) Interactions in Induction of Neurite Outgrowth and Identification of a Binding Site for NCAM in the Heel Region of GDNF
- (2009) J. Nielsen et al. JOURNAL OF NEUROSCIENCE
- Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15
- (2009) J. Strelau et al. JOURNAL OF NEUROSCIENCE
- Nigrostriatal rAAV-mediated GDNF Overexpression Induces Robust Weight Loss in a Rat Model of Age-related Obesity
- (2009) Fredric P Manfredsson et al. MOLECULAR THERAPY
- A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus
- (2008) Tiina Immonen et al. EXPERIMENTAL NEUROLOGY
- The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex
- (2008) Vimal Parkash et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS
- (2008) Masatoshi Suzuki et al. MOLECULAR THERAPY
- GDNF — A potential target to treat addiction
- (2008) Sebastien Carnicella et al. PHARMACOLOGY & THERAPEUTICS
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