Article
Geriatrics & Gerontology
Chi-Wei Kuo, Ming-Yuan Chang, Ming-Yi Chou, Chien-Yuan Pan, Chih-Wei Peng, Hui-Chiun Tseng, Tsu-Yi Jen, Xiao-Kuo He, Hui-Hua Liu, Thi Xuan Dieu Nguyen, Pi-Kai Chang, Tsung-Hsun Hsieh
Summary: This study investigated the therapeutic effects of cortical electrical stimulation (CES) in a rat model of Parkinson's disease (PD). The results demonstrated that early and long-term CES intervention could ameliorate motor dysfunction and exert neuroprotective effects in PD rats.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Ekaterina Menchinskaya, Ekaterina Chingizova, Evgeny Pislyagin, Galina Likhatskaya, Yuri Sabutski, Dmitry Pelageev, Sergei Polonik, Dmitry Aminin
Summary: Targeted screening with a mini-library of 1,4-naphthoquinones resulted in the identification of 10 compounds that can protect neuronal cells from neurotoxins, significantly inhibiting oxidative stress and normalizing mitochondrial function. The neuroprotective properties of these compounds are correlated with their physicochemical properties, indicating that hydrophobicity, polarity, charge, and shape play crucial roles in their biological activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Hao Yu, Xiaojie Liu, Bixuan Chen, Casey R. Vickstrom, Vladislav Friedman, Thomas J. Kelly, Xiaowen Bai, Li Zhao, Cecilia J. Hillard, Qing-Song Liu
Summary: The selective CB2 agonist GW842166x has protective effects against 6-OHDA-induced loss of dopamine neurons and associated motor deficits in mice, potentially through modulation of dopamine neuron firing activity. The neuroprotective effects of GW842166x were prevented by the CB2 receptor antagonist AM630, indicating a CB2-dependent mechanism. Electrophysiological recordings suggest that GW842166x may reduce dopamine neuron vulnerability to 6-OHDA by decreasing action potential firing and associated calcium load.
Article
Behavioral Sciences
Bita Firouzan, Farideh Iravanpour, Fatemeh Abbaszadeh, Valery Akparov, Jalal Zaringhalam, Rasoul Ghasemi, Nader Maghsoudi
Summary: This study investigated the effect of BHME on 6-OHDA-induced motor anomalies. Results showed that BHME prevented motor dysfunction and DA cell death following 6-OHDA injection, which was accompanied by an enhancement in Akt activity, decrement of P38 phosphorylation, and reduction in Bax/Bcl-2 ratio.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarra
Summary: Parkinson's disease is a degenerative disorder of the nervous system with limited treatment options. Research suggests that mandarin juice extract has neuroprotective effects against 6-OHDA-induced cell death and exhibits antioxidant properties, offering a potential strategy for preventing or ameliorating neurodegenerative diseases.
Article
Cell & Tissue Engineering
Dhruv Mahendru, Ashish Jain, Seema Bansal, Deepti Malik, Neha Dhir, Amit Raj Sharma, Phulen Sarma, Ajay Prakash, Uma Nahar, Alka Bhatia, Shalmoli Bhattacharyya, Bikash Medhi
Summary: The study demonstrated that the neuroprotective effect of bone marrow stem cell secretome significantly improved neurobehavioral parameters and biochemical markers in the 6-OHDA model rats. Therefore, mesenchymal stem cells-derived secretome could be a promising approach for managing Parkinson's disease.
REGENERATIVE MEDICINE
(2021)
Article
Neurosciences
Rupinder Kaur Sodhi, Yashika Bansal, Raghunath Singh, Priyanka Saroj, Ranjana Bhandari, Baldeep Kumar, Anurag Kuhad
Summary: In this study, 1-Methyltryptophan (1-MT) was tested in a murine model of PD, showing improvements in locomotion, motor coordination, oxidative stress, neuroinflammatory markers, mitochondrial dysfunction, neuronal apoptosis, neurotransmitter levels, and BDNF levels in the striatum. These findings suggest that 1-MT could be a potential candidate for further studies as an alternative in the pharmacotherapy of PD.
Article
Chemistry, Medicinal
Xin Li, Xiao-wen Jiang, Hai-xiao Chu, Qing-chun Zhao, Huai-wei Ding, Chao-hong Cai
Summary: KuA demonstrates neuroprotective effects in PD models by inhibiting apoptosis, maintaining iron homeostasis, and reducing α-synuclein expression. These findings suggest that KuA may be a potential treatment for Parkinson's disease.
CHINESE HERBAL MEDICINES
(2021)
Article
Immunology
Camila Tiefensee Ribeiro, Daniel Oppermann Peixoto, Lucas Santos, Carolina Saibro-Girardi, Pedro Ozorio Brum, Flavio Gabriel Carazza-Kessler, Nauana Somensi, Luiza Marques Prates Behrens, Reykla Ramon Bittencourt, Laissa Santos Soares, Alexandre Kleber Silveira, Jade de Oliveira, Jose Claudio Fonseca Moreira, Juciano Gasparotto, Daniel Pens Gelain
Summary: The study shows that exogenous HSP70 has a neuroprotective effect in an animal model, improving motor impairment and reducing dopaminergic neuron loss induced by 6-OHDA. Additionally, HSP70 modulates the neuroinflammatory response in the substantia nigra, reducing microglial activation and astrogliosis while decreasing IL-1β mRNA expression in the region. Moreover, exogenous HSP70 increases HSP70 protein content in the substantia nigra, suggesting its neuroprotective role against dopaminergic neuron damage after cellular stress.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)
Article
Pharmacology & Pharmacy
Paivi Poho, Katriina Lipponen, Maxim M. Bespalov, Tiina Sikanen, Tapio Kotiaho, Risto Kostiainen
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Clinical Neurology
Arun Kumar Mahato, Jaakko Kopra, Juho-Matti Renko, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Andrii Domanskyi, Eric Ronken, T. Petteri Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati Karelson, Yulia A. Sidorova, Mart Saarma
MOVEMENT DISORDERS
(2020)
Article
Pharmacology & Pharmacy
Kim J. Blomqvist, Hanna Viisanen, Fredrik H. G. Ahlstrom, Viljami Jokinen, Yulia A. Sidorova, Ilida Suleymanova, Pekka Rauhala, Eija A. Kalso, Tuomas O. Lilius
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Sean Jmaeff, Yulia Sidorova, Hinyu Nedev, Mart Saarma, H. Uri Saragovi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Sean Jmaeff, Yulia Sidorova, Hayley Lippiatt, Pablo F. Barcelona, Hinyu Nedev, Lucia M. Saragovi, Mark A. Hancock, Mart Saarma, H. Uri Saragovi
MOLECULAR PHARMACOLOGY
(2020)
Review
Cell Biology
Arun Kumar Mahato, Yulia A. Sidorova
CELL AND TISSUE RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Yulia A. Sidorova, Mart Saarma
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Arun Kumar Mahato, Yulia A. Sidorova
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Yulia A. Sidorova, Mart Saarma
TRENDS IN PHARMACOLOGICAL SCIENCES
(2020)
Article
Neurosciences
Juho-Matti Renko, Arun Kumar Mahato, Tanel Visnapuu, Konsta Valkonen, Mati Karelson, Merja H. Voutilainen, Mart Saarma, Raimo K. Tuominen, Yulia A. Sidorova
Summary: BT44, a drug-like small molecule, activates GDNF's receptor and shows potential as a novel therapy for Parkinson's disease by promoting dopaminergic neuron survival and reducing motor imbalance.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Neurosciences
F. H. G. Ahlstrom, K. Matlik, H. Viisanen, K. J. Blomqvist, X. Liu, T. O. Lilius, Y. Sidorova, E. A. Kalso, P. V. Rauhala
Summary: Neuropathic pain is more prevalent in women, but the mechanisms of sex differences are not fully understood. Using a rat model, it was found that female rats exhibited stronger mechanical allodynia, and numerous sexually dimorphic changes in gene expression were observed following SNI. These changes involved genes related to T-cells, immunological responses, neuronal transmission, and plasticity, suggesting potential gene targets for sex-specific therapies in neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Neurosciences
Anastasiia Kotliarova, Yulia A. Sidorova
Summary: This article summarizes the effects of GDNF family ligands on neuropathic pain and neuroinflammation, as well as the potential therapeutic implications of targeting GFL receptors in neurodegenerative disorders and neuropathic pain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Yulia Sidorova, Andrii Domanskyi
METHODS AND PROTOCOLS
(2020)
Article
Neurosciences
Hanna Viisanen, Ulpukka Nuotio, Oleg Kambur, Arun Kumar Mahato, Viljami Jokinen, Tuomas Lilius, Wei Li, Helder A. Santos, Mati Karelson, Pekka Rauhala, Eija Kalso, Yulia A. Sidorova
Article
Multidisciplinary Sciences
Leena Yadav, Elina Pietila, Tiina Ohman, Xiaonan Liu, Arun K. Mahato, Yulia Sidorova, Kaisa Lehti, Mart Saarma, Markku Varjosalo
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)