A trans-eQTL network regulates osteoclast multinucleation and bone mass

Trans Effects on Gene Expression Can Drive Omnigenic Inheritance

(2019) Xuanyao Liu et al.   CELL

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass

(2019) Larry D. Mesner et al.   PLoS Genetics

Nosology and classification of genetic skeletal disorders: 2019 revision

(2019) Geert R. Mortier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects

(2018) Carolina Medina-Gomez et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

(2018) Jiaqi Liu et al.   HUMAN GENETICS

Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesisin vitroandin vivo

(2018) Lei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common signalling pathways in macrophage and osteoclast multinucleation

(2018) Marie Pereira et al.   JOURNAL OF CELL SCIENCE

Genetics of trans-regulatory variation in gene expression

(2018) Frank Wolfgang Albert et al.   eLife

Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture

(2018) Stuart K. Kim   PLoS One

Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study

(2018) Katerina Trajanoska et al.   BMJ-British Medical Journal

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

Dissecting the Genetics of Osteoporosis using Systems Approaches

(2018) Basel M. Al-Barghouthi et al.   TRENDS IN GENETICS

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

(2017) John P Kemp et al.   NATURE GENETICS

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

(2017) Gina M. Calabrese et al.   Cell Systems

The State of Systems Genetics in 2017

(2017) Nitin S. Baliga et al.   Cell Systems

Rapid phenotyping of knockout mice to identify genetic determinants of bone strength

(2016) Bernard Freudenthal et al.   JOURNAL OF ENDOCRINOLOGY

Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage–bone crosstalk

(2016) Steven R. Goldring et al.   Nature Reviews Rheumatology

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

(2015) Michael R. Johnson et al.   Nature Communications

Thyroid Hormone Receptor α Mutation Causes a Severe and Thyroxine-Resistant Skeletal Dysplasia in Female Mice

(2014) J. H. Duncan Bassett et al.   ENDOCRINOLOGY

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+T Cells

(2014) Elitsa A. Ananieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density

(2014) Larry D. Mesner et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating Phosphoproteome and Transcriptome Reveals New Determinants of Macrophage Multinucleation

(2014) Maxime Rotival et al.   MOLECULAR & CELLULAR PROTEOMICS

Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

(2014) Heeseog Kang et al.   Cell Reports

The Phosphoinositide 3-Kinase Isoform PI3Kβ Regulates Osteoclast-Mediated Bone Resorption in Humans and Mice

(2014) Dávid Győri et al.   Arthritis & Rheumatology

Metabolic regulation of osteoclast differentiation and function

(2013) Yoriko Indo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Mapping cis- and trans-regulatory effects across multiple tissues in twins

(2012) Elin Grundberg et al.   NATURE GENETICS

Human diseases through the lens of network biology

(2012) Laura I. Furlong   TRENDS IN GENETICS

Systems Genetic Analysis of Osteoblast-Lineage Cells

(2012) Gina Calabrese et al.   PLoS Genetics

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

(2012) J. H. Duncan Bassett et al.   PLoS Genetics

Erratum: Corrigendum: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

(2011) Kerrin S Small et al.   NATURE GENETICS

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inflammatory diseases of the bones and joints

(2011) Edward F. DiCarlo et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Mouse Genome-Wide Association and Systems Genetics Identify Asxl2 As a Regulator of Bone Mineral Density and Osteoclastogenesis

(2011) Charles R. Farber et al.   PLoS Genetics

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

(2010) Eli A Stahl et al.   NATURE GENETICS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL