Article
Immunology
Zhigang Liu, Qiang Zeng, Xinchuan Chen, Chuan He, Fangfang Wang, Ting Liu
Summary: Donor peritoneal-derived cells can attenuate graft-versus-host disease (GVHD) caused by bone marrow transplantation by regulating cytokine levels and immunocyte ratios.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Elena Kum, Gabriele Jagelaviciute, Edward Li, Kenneth Williams, Santhosh Thyagu, Warren Fingrut
Summary: The article tells the story of a Canadian stem cell recipient who underwent transplantation from a matched unrelated donor for refractory chronic myelogenous leukemia, showcasing different perspectives and encouraging people to become donors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martin H. Cherk, Robert Khor, Thomas W. Barber, Kenneth S. K. Yap, Sushrut Patil, Patricia Walker, Sharon Avery, Stuart Roberts, William Kemp, Alan Pham, Michael Bailey, Victor Kalff
Summary: This study evaluated the diagnostic utility of 18F-FDG PET/CT for acute GIT-GVHD. The results showed that 18F-FDG PET/CT is a useful noninvasive diagnostic test, with high sensitivity and specificity for detecting acute GIT-GVHD. It was also found that acute GIT-GVHD typically involves the colon and can be confirmed by colonic biopsy obtained by sigmoidoscopy. However, 18F-FDG PET cannot distinguish acute GIT-GVHD from non-GVHD inflammatory changes in the colon.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Virology
Christine J. Chang, Luzmariel Medina Sanchez, Aditya Vageesh, Alexandra J. Popkov, Adithya Chandrasekaran, Bethany B. Moore, Jason B. Weinberg
Summary: Long-term persistence of DNA viruses in the infected host is crucial for their life cycle. The nature of adenovirus persistence following acute infection is not fully understood. In this study, we found that mouse adenovirus type 1 (MAV-1) persists for a prolonged period in multiple organs of infected mice without ongoing replication. Furthermore, MAV-1 persistence exacerbated graft-versus-host disease-like inflammation following allogeneic bone marrow transplantation, even in the absence of virus reactivation. These findings suggest that adenovirus persistence can have consequences and influence host responses to unrelated challenges.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, Research & Experimental
Erika S. Varady, L. Angel Ayala, Pauline U. Nguyen, Vanessa M. Scarfone, Alborz Karimzadeh, Cuiwen Zhou, Xiyu Chen, Scott A. Greilach, Craig M. Walsh, Matthew A. Inlay
Summary: Donor cell conditioning with the glucocorticoid fluticasone propionate (FLU) prior to transplantation increases HSC engraftment and reduces the severity and incidence of graft-versus-host disease (GvHD) in allogeneic hosts.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daniel E. Maidana, Lucia Gonzalez-Buendia, Joan W. Miller, Demetrios G. Vavvas
Summary: Recent evidence suggests that modulating the RIPK3 pathway can improve the survival of transplanted cells and aid in the repair of degenerated retinas. Simultaneous inhibition of RIPK3 in both the donor and host can maximize the survival of transplanted cells. Additionally, targeting RIPK3 in the immune system can protect both donor and host retinal cells. These findings highlight the potential of immunomodulatory and neuroprotective strategies targeting RIPK3 in the regenerative therapy of photoreceptor transplantation.
Article
Immunology
Pooja Khandelwal, Rosa F. Yeh, Louie Yu, Adam Lane, Christopher E. Dandoy, Javier El-Bietar, Stella M. Davies, Michael S. Grimley
Summary: The addition of abatacept to standard acute GVHD prophylaxis effectively reduced the incidence of severe acute GVHD in children with beta-thalassemia major undergoing HSCT, without affecting engraftment. Thalassemia-free survival was significantly higher in the abatacept group compared to the standard group.
Article
Immunology
Qianqian Wang, Xiuhua Su, Yi He, Mei Wang, Donglin Yang, Rongli Zhang, Jialin Wei, Qiaoling Ma, Weihua Zhai, Aiming Pang, Yong Huang, Sizhou Feng, Christie M. Ballantyne, Huaizhu Wu, Xiaolei Pei, Xiaoming Feng, Mingzhe Han, Erlie Jiang
Summary: Blocking CD11c inhibits T cell proliferation and differentiation into Th1 cells, playing crucial roles in aGVHD pathogenesis. CD11c deficiency alleviates aGVHD symptoms by affecting antigen presentation of DCs.
Article
Biophysics
Patrick J. Hayden, Dirk-Jan Eikema, Liesbeth C. de Wreede, Linda Koster, Nicolaus Kroger, Hermann Einsele, Monique Minnema, Alida Dominietto, Michael Potter, Jacob Passweg, Arancha Bermudez, Stephanie Nguyen-quoc, Uwe Platzbecker, Johanna Tischer, Fabio Ciceri, Joan Hendrik Veelken, Per Ljungman, Nicolaas Schaap, Edouard Forcade, Angelo Michele Carella, Virginie Gandemer, William Arcese, Adrian Bloor, Attilio Olivieri, Laure Vincent, Meral Beksac, Stefan Schonland, Ibrahim Yakoub-Agha
Summary: For patients with relapsed multiple myeloma, receiving a second allo-HCT from a HLA-identical sibling donor for both transplants is associated with higher overall survival rates. Additionally, an interval of more than 2 years between transplants is associated with superior 5-year survival rates.
BONE MARROW TRANSPLANTATION
(2021)
Article
Microbiology
Shiela McCollam, James S. Lewis, Joseph Bubalo, Amber Diaz
Summary: This study aimed to evaluate the efficacy and safety of 300-mg once-monthly intravenous (IV) pentamidine prophylaxis in 702 adult allogeneic hematopoietic stem cell transplant (HSCT) patients. The results showed that IV pentamidine administration effectively prevented Pneumocystis jirovecii pneumonia (PJP), but breakthrough Nocardia and Toxoplasma infections were observed in a certain percentage of patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Konradin F. Muskens, Caroline A. Lindemans, Mirjam E. Belderbos
Summary: GvHD is a major complication of HCT, causing severe hematopoietic dysfunction. Immune activation during GvHD damages hematopoietic stem cells and their niche in the bone marrow, leading to reduced functionality. Complications and treatments associated with HCT exacerbate hematopoietic dysfunction.
Article
Surgery
Cecile Chague, Thomas Gautier, Ludivine Dal Zuffo, Jean-Paul Pais de Barros, Audrey Wetzel, Georges Tarris, Gaetan Pallot, Laurent Martin, Severine Valmary-Degano, Valerie Deckert, Laurent Lagrost, Etienne Daguindau, Philippe Saas
Summary: This study found that HDL deficiency leads to LPS accumulation and exacerbates aGVHD. However, administration of HDL isolated from human plasma significantly decreases the mortality and severity of aGVHD. HDL infusion also plays an important role in mitigating liver aGVHD by reducing immune infiltration and inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Hematology
Asim Saha, Sharon Hyzy, Tahirih Lamothe, Katelyn Hammond, Nicholas Clark, Leanne Lanieri, Prashant Bhattarai, Rahul Palchaudhuri, Geoffrey O. Gillard, Jennifer Proctor, Megan J. Riddle, Angela Panoskaltsis-Mortari, Margaret L. MacMillan, John E. Wagner, Hans-Peter Kiem, Lisa M. Olson, Bruce R. Blazar
Summary: Allo-HSCT is a potential curative treatment for blood disorders, but graft-versus-host disease (GVHD) limits its success. CD45-ADC, an antibody-drug-conjugate, facilitates stable donor cell engraftment and provides a new approach to reduce treatment toxicity.
Review
Immunology
Berislav Bosnjak, Kim Thi Hoang Do, Reinhold Foerster, Swantje Hammerschmidt
Summary: Dendritic cells (DCs) play a crucial role in initiating adaptive immune responses by capturing antigens during inflammation and inducing tolerance under non-inflammatory conditions. Understanding DC biology is essential for vaccine development and autoimmune disease prevention. Bioimaging tools are crucial for tracking DCs in tissues and organs and visualizing subcellular and molecular processes.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Malte Deseke, Francesca Rampoldi, Inga Sandrock, Eva Borst, Heike Boning, George Liam Ssebyatika, Carina Jurgens, Nina Pluckebaum, Maleen Beck, Ahmed Hassan, Likai Tan, Abdi Demera, Anika Janssen, Peter Steinberger, Christian Koenecke, Abel Viejo-Borbolla, Martin Messerle, Thomas Krey, Immo Prinz
Summary: Deseke et al. identified HLA-DR as the cognate TCR ligand of a CMV-induced V delta 1(+) gamma delta T cell clone using soluble gamma delta TCRs and CRISPR/Cas9-mediated screening. This study provides insights into the potential role of HLA-DR in adaptive immune responses of gamma delta T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Oncology
Heiner Zimmermann, Christian Koenecke, Martin H. Dreyling, Christiane Pott, Ulrich Duehrsen, Dennis Hahn, Norbert Meidenbauer, Ingeborg A. Hauser, Mathias J. Rummel, Dominik Wolf, Michael Heuser, Christian Schmidt, Peter Schlattmann, Matthias Ritgen, Reiner Siebert, Ilske Oschlies, Ioannis Anagnostopoulos, Ralf U. Trappe
Summary: This study investigated the efficacy of a modified risk-stratification strategy in adult SOT recipients with CD20-positive PTLD. The results showed that this strategy achieved a favorable event-free survival rate in the low-risk group, while immunotherapy intensification in the very-high-risk group had disappointing results.
Article
Oncology
Stephanie Sasse, Paul Jan Brockelmann, Jesko Momotow, Annette Plutschow, Andreas Huttmann, Nadezda Basara, Christian Koenecke, Sonja Martin, Martin Bentz, Christina Grosse-Thie, Sven Thorspecken, Maike de Wit, Carsten Kobe, Markus Dietlein, Bastian v Tresckow, Michael Fuchs, Peter Borchmann, Andreas Engert
Summary: The efficacy of bispecific antibody AFM13 in patients with relapsed classical Hodgkin lymphoma is modest, with an objective response rate of 16.7% and a 12-month progression-free survival rate of 12.6% in all evaluated patients.
LEUKEMIA & LYMPHOMA
(2022)
Article
Public, Environmental & Occupational Health
Claas Baier, Jiabin Huang, Kerstin Reumann, Daniela Indenbirken, Felicitas Thol, Christian Koenecke, Ella Ebadi, Albert Heim, Franz-Christoph Bange, Sibylle Haid, Thomas Pietschmann, Nicole Fischer
Summary: This study investigated an RSV outbreak in an adult hematology ward using epidemiologic and molecular analyses, emphasizing the importance of multimodal infection control and early respiratory virus screening for patients with hematologic diseases.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Medicine, General & Internal
Anna Waszczuk-Gajda, Olaf Penack, Giulia Sbianchi, Linda Koster, Didier Blaise, Peter Remenyi, Nigel Russell, Per Ljungman, Marek Trneny, Jiri Mayer, Simona Iacobelli, Guido Kobbe, Christof Scheid, Jane Apperley, Cyrille Touzeau, Stig Lenhoff, Esa Jantunen, Achilles Anagnostopoulos, Laura Paris, Paul Browne, Catherine Thieblemont, Nicolaas Schaap, Jorge Sierra, Ibrahim Yakoub-Agha, Laurent Garderet, Jan Styczynski, Helene Schoemans, Ivan Moiseev, Rafael F. Duarte, Zinaida Peric, Silvia Montoto, Anja van Biezen, Malgorzata Mikulska, Mahmoud Aljurf, Tapani Ruutu, Nicolaus Kroeger, Curly Morris, Christian Koenecke, Stefan Schoenland, Grzegorz W. Basak
Summary: This post hoc analysis evaluated the rate of infectious and non-infectious complications after ASCT in multiple myeloma patients. The analysis included 3552 patients and found that complication rates decreased over time. Bacterial infections and gastrointestinal complications were the most common early events. The occurrence of complications was not associated with overall survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jessica Schneider, Leonie Kuhlmann, Yankai Xiao, Solaiman Raha, Gunter Bernhardt, Michael Stadler, Felicitas Thol, Michael Heuser, Matthias Eder, Arnold Ganser, Sarina Ravens, Reinhold Forster, Immo Prinz, Christian Koenecke, Christian R. Schultze-Florey
Summary: Donor lymphocyte infusion (DLI) can induce durable remission in relapsing patients after alloHSCT, but it carries the risk of graft-versus-host disease (GVHD). This study analyzed T cells in patients receiving DLI after alloHSCT and found that GVHD was associated with changes in the T-cell receptor (TCR) repertoire. The dynamics of CD4(+)CD25(+)CD127(low) regulatory T cells (T-reg cells) and CD4(+) conventional T cells (T-con cells) TCR repertoire could be helpful in diagnosing and monitoring GVHD following DLI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ivan Odak, Ruth Sikora, Lennart Riemann, Lale M. Bayir, Maleen Beck, Melanie Drenker, Yankai Xiao, Jessica Schneider, Elke Dammann, Michael Stadler, Matthias Eder, Arnold Ganser, Reinhold Foerster, Christian Koenecke, Christian R. Schultze-Florey
Summary: This study investigated the immune phenotypes associated with durable graft-versus-leukemia (GVL) response following donor lymphocyte infusions (DLI). The study found that differentially activated T cell clusters in DLI cell products and in patients post infusion were associated with AML relapse. The composition of DLI cell products may influence GVL.
FRONTIERS IN IMMUNOLOGY
(2022)
Meeting Abstract
Hematology
Peter Bader, Claudia Rossig, Martin Hutter, Francis A. Ayuk, Claudia D. Baldus, Veit L. Buecklein, Halvard Bonig, Gunnar Cario, Hermann Einsele, Udo Holtick, Christian Koenecke, Annette Kuenkele, Roland Meisel, Fabian Mueller, Ingo Mueller, Olaf Penack, Eva Rettinger, Martin G. Sauer, Paul-Gerhardt Schlegel, Jan Soerensen, Arend von Stackelberg, Tobias Feuchtinger, Andrea Jarisch
Meeting Abstract
Hematology
Rabia Shahswar, Gernot Beutel, Razif Gabdoulline, Adrian Schwarzer, Arnold Kloos, Christian Koenecke, Michael Stadler, Gudrun Goehring, Brigitte Schlegelberger, Zhixiong Li, Louisa-Kristin Dallmann, Clara Wienecke, Piroska Klement, Catherin Albert, Martin Wichmann, Yasmine Alwie, Axel Benner, Maral Saadati, Arnold Ganser, Felicitas R. Thol, Michael Heuser
Letter
Biophysics
Ivan Moiseev, Pascale Ambron, Manuela Badoglio, Christophe Peczynski, Grzegorz Basak, Christian Koenecke, Helene Schoemans, Olaf Penack, Zinaida Peric
BONE MARROW TRANSPLANTATION
(2023)
Review
Immunology
Immo Prinz, Christian Koenecke
Summary: Gamma delta T cells play a crucial role in controlling viral infections, particularly in immunocompromised patients after stem cell transplantation. Recent findings suggest that these cells exhibit an adaptive-like immune response to cytomegalovirus (CMV), with long-lasting clonal expansion and effector functions. It is proposed that gamma delta TCRs are triggered by CMV-induced self-antigens rather than viral antigens. Moreover, the cross-reactivity of CMV-activated gamma delta TCRs with tumor cells makes them promising tools for antiviral and antitumor therapy.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Meeting Abstract
Oncology
John B. A. G. Haanen, Andreas Mackensen, Christian Koenecke, Winfried Alsdorf, Eva Wagner-Drouet, Daniel Heudobler, Peter Borchmann, Carsten Bokemeyer, Sebastian Klobuch, Alexander Desuki, Florian Lueke, Erol Wiegert, Catrine Schulz, Benjamin Rengstl, Liane Preussner, Oezlem Tuereci, Ugur Sahin
Meeting Abstract
Oncology
Attaya Suvannasankha, Nizar J. Bahlis, Suzanne Trudel, Katja Weisel, Christian Koenecke, Albert Oriol Rocafiguera, Peter M. Voorhees, Aranzazu Alonso Alonso, Natalie Scott Callander, Maria-Victoria Mateos, Nishitha Reddy, Shawn Hakim, Nashita Patel, Danae Williams, Roxanne C. Jewell, Xiangdong Zhou, Ira V. Gupta, Ajay K. Nooka
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Janine Dywicki, Laura Elisa Buitrago-Molin, Fatih Noyan, Ana C. Davalos-Misslitz, Katharina L. Hupa-Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel
Summary: Studies have shown that feeding NASH-resistant BALB/c mice with a high-fat high-carbohydrate diet can activate intrahepatic T cells, while the absence of the adaptive immune response has a significant impact on NASH. The increase in intrahepatic Treg numbers in NASH patients did not improve NASH and unexpected had negative effects when Treg transfer or anti-CD3 therapy were attempted.
HEPATOLOGY COMMUNICATIONS
(2022)