The Role of Neutrophil NETosis in Organ Injury: Novel Inflammatory Cell Death Mechanisms

The antidiabetic drug metformin blunts NETosis in vitro and reduces circulating NETosis biomarkers in vivo

(2018) Lisa Menegazzo et al.   ACTA DIABETOLOGICA

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Markers of neutrophil extracellular traps predict adverse outcome in community-acquired pneumonia: secondary analysis of a randomised controlled trial

(2018) Fahim Ebrahimi et al.   EUROPEAN RESPIRATORY JOURNAL

REDD1/Autophagy Pathway Is Associated with Neutrophil-Driven IL-1β Inflammatory Response in Active Ulcerative Colitis

(2018) Iliana Angelidou et al.   JOURNAL OF IMMUNOLOGY

Impaired neutrophil extracellular traps and inflammatory responses in the peritoneal fluid of patients with liver cirrhosis

(2018) Juan Manuel Agraz-Cibrián et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Dexamethasone Inhibits S. aureus-Induced Neutrophil Extracellular Pathogen-Killing Mechanism, Possibly through Toll-Like Receptor Regulation

(2017) Ting Wan et al.   Frontiers in Immunology

NETosis in Alzheimer’s Disease

(2017) Enrica Caterina Pietronigro et al.   Frontiers in Immunology

Extracellular Acidification Inhibits the ROS-Dependent Formation of Neutrophil Extracellular Traps

(2017) Martina Behnen et al.   Frontiers in Immunology

Neutrophil Extracellular Traps Promote AngiogenesisHighlights

(2016) Lulwah Aldabbous et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model

(2016) L. Erpenbeck et al.   BIOLOGY OF REPRODUCTION

NETosis Delays Diabetic Wound Healing in Mice and Humans

(2016) Gian Paolo Fadini et al.   DIABETES

Effects of the antioxidants Trolox, Tiron and Tempol on neutrophil extracellular trap formation

(2016) Nina V. Vorobjeva et al.   IMMUNOBIOLOGY

Induction of Neutrophil Extracellular Traps in Shiga Toxin-Associated Hemolytic Uremic Syndrome

(2016) Maria Victoria Ramos et al.   Journal of Innate Immunity

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Neutrophil migration into the placenta: Good, bad or deadly?

(2016) Stavros Giaglis et al.   Cell Adhesion & Migration

Alterations in neutrophil extracellular traps is associated with the degree of decompensation of liver cirrhosis

(2016) Juan M Agraz-Cibrian et al.   Journal of Infection in Developing Countries

Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs

(2016) Christian Maueröder et al.   Frontiers in Immunology

Multimodal Regulation of NET Formation in Pregnancy: Progesterone Antagonizes the Pro-NETotic Effect of Estrogen and G-CSF

(2016) Stavros Giaglis et al.   Frontiers in Immunology

Damage-associated molecular pattern-activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

(2015) Hai Huang et al.   HEPATOLOGY

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof-of-Concept Trial of Metformin

(2015) Haiting Wang et al.   Arthritis & Rheumatology

Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis

(2014) Jason S. Knight et al.   CIRCULATION RESEARCH

Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance

(2014) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

Stroke Alters Respiratory Burst in Neutrophils and Monocytes

(2014) Johanna Ruhnau et al.   STROKE

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Footprints of Neutrophil Extracellular Traps as Predictors of Cardiovascular Risk

(2013) Yvonne Döring et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Neutrophils and emerging targets for treatment in chronic obstructive pulmonary disease

(2013) Mariska Meijer et al.   Expert Review of Clinical Immunology

The Role of Polymorphonuclear Leukocyte Trafficking in the Perpetuation of Inflammation During Inflammatory Bowel Disease

(2013) Jennifer C. Brazil et al.   INFLAMMATORY BOWEL DISEASES

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

(2012) Yvonne Döring et al.   CIRCULATION RESEARCH

Inhibition of mammalian target of rapamycin aggravates the respiratory burst defect of neutrophils from decompensated patients with cirrhosis

(2012) Loïc Rolas et al.   HEPATOLOGY

Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity

(2012) Yuji Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions

(2012) Baohai Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Presence of luminal neutrophil extracellular traps in atherosclerosis

(2012) Remco T. A. Megens et al.   THROMBOSIS AND HAEMOSTASIS

Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction

(2012) Xiaofei Li et al.   THROMBOSIS AND HAEMOSTASIS

An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity

(2012) Annapurna Nayak et al.   Frontiers in Immunology

Stable Redox-Cycling Nitroxide Tempol Inhibits NET Formation

(2012) Ava Hosseinzadeh et al.   Frontiers in Immunology

Preeclampsia, a Disease of the Maternal Endothelium

(2011) Camille E. Powe et al.   CIRCULATION

Ultrastructural characterization of cystic fibrosis sputum using atomic force and scanning electron microscopy

(2011) Reinhard Manzenreiter et al.   Journal of Cystic Fibrosis

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

(2011) Ioannis Mitroulis et al.   PLoS One

Neutrophil Elastase Enhances Sputum Solubilization in Cystic Fibrosis Patients Receiving DNase Therapy

(2011) Venizelos Papayannopoulos et al.   PLoS One

Immunological consequences of ischemic stroke: Immunosuppression and autoimmunity

(2010) Antje Vogelgesang et al.   JOURNAL OF NEUROIMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation

(2010) Satyananda Patel et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps

(2009) S Yousefi et al.   CELL DEATH AND DIFFERENTIATION

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

(2009) Mark R. Looney et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed neutrophil respiratory burst in patients with haemorrhagic stroke

(2009) Yukio Seki et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Role of neutrophils in innate immunity: a systems biology-level approach

(2009) Scott D. Kobayashi et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma

(2007) Joanne Shannon et al.   CHEST

Analysis of Lymphocyte Subsets in Patients With Stroke and Their Influence on Infection After Stroke

(2007) Antje Vogelgesang et al.   STROKE