Neutrophils and emerging targets for treatment in chronic obstructive pulmonary disease

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

(2013) Bianca Beghè et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases

(2013) Srividya Sriskantharajah et al.   Annals of the New York Academy of Sciences

Experimental immunology Extracellular Traps: How to isolate and quantify extracellular DNA (ET-DNA)

(2013) Mariska Meijer et al.   Central European Journal of Immunology

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Pharmacological and Dietary Antioxidant Therapies for Chronic Obstructive Pulmonary Disease

(2013) S. Biswas et al.   CURRENT MEDICINAL CHEMISTRY

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

New anti-inflammatory targets for chronic obstructive pulmonary disease

(2013) Peter J. Barnes   NATURE REVIEWS DRUG DISCOVERY

Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?

(2013) Saskia A. Overbeek et al.   PLoS One

Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate

(2013) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrolide Therapy Decreases Chronic Obstructive Pulmonary Disease Exacerbation: A Meta-Analysis

(2013) Guo-Yan Yao et al.   RESPIRATION

Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

(2013) Christine M Freeman et al.   RESPIRATORY RESEARCH

Diet and vitamin D as risk factors for lung impairment and COPD

(2013) Corrine Hanson et al.   Translational Research

Recent advances in α-1-antitrypsin deficiency-related lung disease

(2013) Judith A Brebner et al.   Expert Review of Respiratory Medicine

Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells

(2012) Nadia Moretto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

An Association between Neutrophils and Immunoglobulin Free Light Chains in the Pathogenesis of Chronic Obstructive Pulmonary Disease

(2012) Saskia Braber et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke

(2012) Rajesh K. Thimmulappa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel Antiinflammatory Therapies for COPD

(2012) Nicholas J. Gross   CHEST

p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD

(2012) Audreesh Banerjee et al.   CURRENT OPINION IN PHARMACOLOGY

Delayed apoptosis by neutrophils from COPD patients is associated with altered bak, bcl-xl, and mcl-1 mRNA expression

(2012) Jisong Zhang et al.   Diagnostic Pathology

A -Val360: a marker of neutrophil elastase and COPD disease activity

(2012) R. I. Carter et al.   EUROPEAN RESPIRATORY JOURNAL

Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation

(2012) Ulrich Sydlik et al.   EUROPEAN RESPIRATORY JOURNAL

Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs

(2012) Kate Gaffey et al.   EUROPEAN RESPIRATORY JOURNAL

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury

(2012) Axelle Caudrillier et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of nitric oxide synthesis enhances leukocyte rolling and adhesion in human microvasculature

(2012) Mokarram Hossain et al.   Journal of Inflammation-London

Glucocorticosteroids Differentially Regulate MMP-9 and Neutrophil Elastase in COPD

(2012) Ross Vlahos et al.   PLoS One

Statins, systemic inflammation and risk of death in COPD: The Rotterdam study

(2012) Lies Lahousse et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Increased neutrophil migration in smokers with or without chronic obstructive pulmonary disease

(2012) KRISTIN BLIDBERG et al.   RESPIROLOGY

Lung-Targeted Overexpression of the NF-κB Member RelB Inhibits Cigarette Smoke–Induced Inflammation

(2011) David H. McMillan et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix Elastin

(2011) Gerard M. Turino et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

What is the potential for inhaled p38 inhibitors in the treatment of chronic obstructive pulmonary disease?

(2011) David S Millan   Future Medicinal Chemistry

Chemokine release by neutrophils in chronic obstructive pulmonary disease

(2011) Kristin Blidberg et al.   Innate Immunity

Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation

(2011) Ivana Stanojkovic et al.   RESPIRATORY MEDICINE

A unique protein profile of peripheral neutrophils from COPD patients does not reflect cytokine-induced protein profiles of neutrophils in vitro

(2011) Jeroen D Langereis et al.   BMC Pulmonary Medicine

Glutathione cycle in stable chronic obstructive pulmonary disease

(2010) Vanja Radišić Biljak et al.   CELL BIOCHEMISTRY AND FUNCTION

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

The Transmembrane Domains of L-selectin and CD44 Regulate Receptor Cell Surface Positioning and Leukocyte Adhesion under Flow

(2010) Konrad Buscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients

(2010) Suzana E Tanni et al.   Journal of Inflammation-London

Abrogation of NF-κB signaling in human neutrophils induces neutrophil survival through sustained p38-MAPK activation

(2010) Jeroen D. Langereis et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anti-Inflammatory Properties of a Novel N-Phenyl Pyridinone Inhibitor of p38 Mitogen-Activated Protein Kinase: Preclinical-to-Clinical Translation

(2009) H. R. Hope et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An elegant defense: how neutrophils shape the immune response

(2009) Oliver Soehnlein   TRENDS IN IMMUNOLOGY

The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the NF-κB Family Member RelB

(2008) Carolyn J. Baglole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery

(2008) Qin Liu et al.   JOURNAL OF BIOMECHANICS

Increased activation of p38 MAPK in COPD

(2007) T. Renda et al.   EUROPEAN RESPIRATORY JOURNAL