Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

Published 2019 View Full Article

Authors

Keywords

TDP-43, RNA-binding proteins, low complexity domains, liquid-liquid phase separation, TDP-43 de-mixing, stress granules, iPSCs, motor neurons, neurodegeneration, ALS/FTD, nucleocytoplasmic transport

Journal

NEURON

Volume -, Issue -, Pages -

Publisher

Elsevier BV

Online

2019-03-07

DOI

10.1016/j.neuron.2019.02.038

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