Review
Pharmacology & Pharmacy
Abiramy Jeyagaran, Chuan-en Lu, Aline Zbinden, Andreas L. Birkenfeld, Sara Y. Brucker, Shannon L. Layland
Summary: The development of new therapeutic approaches to treat type 1 diabetes mellitus relies on understanding the biology of insulin-secreting p-cells and the mechanisms responsible for their autoimmune destruction. This review discusses the current state of p-cell differentiation and the possibilities for enhancing insulin-secreting cell/islet transplantation from a translational perspective.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Cell Biology
Xiao-Ning Zhang, Kai-Di Yang, Cong Chen, Zhi-Cheng He, Qiang-Hu Wang, Hua Feng, Sheng-Qing Lv, Yan Wang, Min Mao, Qing Liu, Yao-Yao Tan, Wen-Ying Wang, Tian-Ran Li, Lin-Rong Che, Zhong-Yi Qin, Ling-Xiang Wu, Min Luo, Chun-Hua Luo, Yu-Qi Liu, Wen Yin, Chao Wang, Hai-Tao Guo, Qing-Rui Li, Bin Wang, Wei Chen, Shuang Wang, Yu Shi, Xiu-Wu Bian, Yi-Fang Ping
Summary: The study reveals the role of pericytes in potentiating DDR signaling in GBM cells, and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM.
Article
Biochemistry & Molecular Biology
Shangce Du, Zhi Yang, Xiaofeng Lu, Suhail Yousuf, Min Zhao, Wenxi Li, Ji Miao, Xingzhou Wang, Heng Yu, Xinya Zhu, Hong Chen, Linseng Shi, En Xu, Xuefeng Xia, Wenxian Guan
Summary: Anoikis resistance is crucial for the survival of metastatic cancer cells, but the molecular mechanisms are poorly understood. Study found that GC(AR) cells exhibit stronger metastatic and pro-angiogenic traits, promoting GC cell survival and angiogenesis through elevated PDGFB secretion.
Article
Endocrinology & Metabolism
Mikael Chetboun, Elodie Drumez, Cassandra Ballou, Mehdi Maanaoui, Elizabeth Payne, Franca Barton, Julie Kerr-Conte, Marie-Christine Vantyghem, Lorenzo Piemonti, Michael R. Rickels, Julien Labreuche, Francois Pattou
Summary: This global multicentre study shows a linear and independent association between primary graft function (PGF) and 5-year clinical outcomes of islet transplantation. The study reveals that PGF is closely related to the success rate of islet transplantation, graft exhaustion, inadequate glucose control, and the need for exogenous insulin therapy. It emphasizes the importance of PGF in long-term outcomes of islet transplantation.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Cell Biology
Annie R. Pineros, Abhishek Kulkarni, Hongyu Gao, Kara S. Orr, Lindsey Glenn, Fei Huang, Yunlong Liu, Maureen Gannon, Farooq Syed, Wenting Wu, Cara M. Anderson, Carmella Evans-Molina, Marcia McDuffie, Jerry L. Nadler, Margaret A. Morris, Raghavendra G. Mirmira, Sarah A. Tersey
Summary: This study suggests that inflammatory signaling in beta cells promotes autoimmunity during the progression of type 1 diabetes. By deleting a specific proinflammatory gene in mice, the researchers found that the preservation of beta cell mass and reduction in infiltrating T cell populations protected against spontaneous autoimmune diabetes.
Article
Dentistry, Oral Surgery & Medicine
A. Vijaykumar, S. H. Root, M. Mina
Summary: The study found that treatment with WNT3a did not induce premature differentiation of odontoblasts, but instead supported the survival of undifferentiated cells and promoted the formation of preodontoblasts in dental pulp, facilitating their rapid transition into differentiated odontoblasts. Additionally, WNT3a was also found to promote osteogenesis in dental pulp cultures. These findings provide valuable insights for improving vital pulp therapy and dentin regeneration treatments.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jesus Paez-Mayorga, Jocelyn Nikita Campa-Carranza, Simone Capuani, Nathanael Hernandez, Hsuan-Chen Liu, Corrine Ying Xuan Chua, Fernanda Paola Pons-Faudoa, Gulsah Malgir, Bella Alvarez, Jean A. Niles, Lissenya B. Argueta, Kathryn A. Shelton, Sarah Kezar, Pramod N. Nehete, Dora M. Berman, Melissa A. Willman, Xian C. Li, Camillo Ricordi, Joan E. Nichols, A. Osama Gaber, Norma S. Kenyon, Alessandro Grattoni
Summary: By using the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, pancreatic islet transplantation for type 1 diabetes can achieve long-term reversal without the need for systemic immunosuppression, making it a promising approach for effective treatment.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Byung Soo Kong, Se Hee Min, Changhan Lee, Young Min Cho
Summary: The study showed that MOTS-c prevents autoimmune diabetes by modulating T cell receptor signaling, and demonstrated potential therapeutic effects in patients with Type 1 diabetes.
Article
Surgery
Wenyu Gou, Jingjing Wang, Lili Song, Do-Sung Kim, Wanxing Cui, Charlie Strange, Hongjun Wang
Summary: The study showed that AAT protects transplanted islets from death and dysfunction by suppressing cytokine-induced macrophage activation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Endocrinology & Metabolism
Ji-Hyun Lee, Ji-Hyeon Lee, Sushil G. Rane
Summary: Pancreatic islet beta cells play a crucial role in diabetes development, with the TGF-β pathway playing an important role in regulating beta cell development, proliferation, and function. This supports the research and therapeutic potential of targeting the TGF-β pathway in diabetes.
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Butian Wei, Xin Zhang, Jiwei Qian, Zhe Tang, Bo Zhang
Summary: Nrf2 is an important intracellular regulator of antioxidant stress, regulating not only antioxidant function but also insulin secretion, proliferation, and differentiation of beta cells, ER stress, and mitochondrial function. Pharmacological activation of Nrf2 has been shown to protect islet cells during different stages of transplantation in experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V. Carr, Julian Van Gerwen, Elise J. Needham, Dillon Jevon, Sing-Young Chen, Kyle L. Hoehn, Amanda E. Brandon, Laurence Macia, Gregory J. Cooney, Michael R. Shortreed, Lloyd M. Smith, Mark P. Keller, Peter Thorn, Mark Larance, David E. James, Sean J. Humphrey, Melkam A. Kebede
Summary: Pancreatic islets are crucial for maintaining blood glucose levels, with declining function being a characteristic of type 2 diabetes. A detailed proteomic analysis of mouse islets from various genetic or diet-induced models revealed that most proteins are expressed in all strains and diets, but with varying levels due to genetics. Islet mitochondrial function was identified as a major positive indicator of metabolic health across different strains.
Review
Endocrinology & Metabolism
Alba M. Polonio, Juan A. Garcia-Velasco, Sonia Herraiz
Summary: Premature ovarian insufficiency is a common disorder affecting young women and the lack of effective treatments has led to exploration of stem cell therapy, which shows promising results in clinical trials for ovarian health.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Shenqi Wang, Zimin Zhou, Rini Rahiman, Grace Sheen Yee Lee, Yuan Kai Yeo, Xin Yang, On Sun Lau
Summary: Developmental outcomes in plants are shaped by the interplay between intrinsic and external factors, with light playing a key role in promoting stomatal development. The study by Wang et al. reveals that the light-regulated transcription factor HY5 activates the expression of STOMAGEN, a mesophyll-derived secreted peptide that stabilizes the master regulator of stomatal development in the epidermis, leading to enhanced stomatal production. This work highlights a molecular link between light signaling and stomatal development across different tissue layers.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Antu Antony, Zeqin Lian, Xiaoyuan Dai Perrard, Jerry Perrard, Hua Liu, Aaron R. Cox, Pradip Saha, Lothar Hennighausen, Sean M. Hartig, Christie M. Ballantyne, Huaizhu Wu
Summary: This study investigated the role of Stat1 in obesity-induced MDC polarization and inflammation, using mice with specific knockout of Stat1 in MDCs. The results showed that Stat1 in MDCs plays a crucial role in promoting M1-like polarization, contributing to AT inflammation, insulin resistance, and metabolic dysfunctions in obese mice.
Article
Multidisciplinary Sciences
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, Pradip K. Saha, Huaizhu Wu, Christie M. Ballantyne, Sean M. Hartig, Liang Xie, Xinchun Pi
Summary: The role of endothelial BMPER function in glucose homeostasis is crucial, and overexpression of BMPER has been shown to alleviate insulin resistance and hyperglycemia in diabetic mice.
NATURE COMMUNICATIONS
(2021)
Review
Endocrinology & Metabolism
Kang Ho Kim, Sean M. Hartig
Summary: MicroRNA levels are correlated with metabolic diseases and regulate central metabolic pathways to maintain organismal energy balance and metabolic homeostasis. Research on the roles and regulation of microRNAs in conferring insulin sensitivity in peripheral tissues is progressing, with sequencing technologies being used to define the target spectrum of microRNAs in metabolic diseases. The emerging roles of exosomal microRNAs as endocrine signals in regulating lipid and carbohydrate metabolism are also discussed.
Article
Physiology
Neeti Agarwal, Claudia E. Ramirez Bustamante, Huaizhu Wu, Reina Armamento-Villareal, Jordan E. Lake, Ashok Balasubramanyam, Sean M. Hartig
Summary: Plasma biomarkers reflecting energy balance disorders in people living with HIV (PLWH) are limited. Growth differentiation factor 15 (GDF15) abundance in plasma has been associated with negative energy balance, obesity, and metabolic diseases. This study compared plasma GDF15 levels in PLWH, HIV-negative individuals, and mouse models expressing the HIV accessory protein Vpr. Elevated plasma GDF15 levels were found in PLWH and Vpr mouse models, and correlated with certain metabolic parameters.
PHYSIOLOGICAL REPORTS
(2022)
Review
Endocrinology & Metabolism
Claudia E. Ramirez Bustamante, Neeti Agarwal, Aaron R. Cox, Sean M. Hartig, Jordan E. Lake, Ashok Balasubramanyam
Summary: Over the past 4 decades, the clinical care of people living with HIV has shifted from treatment of infections to the management of chronic comorbidities. Adipose tissue dysfunction plays a role in the changes in body composition and adiposity that occur in PLWH, increasing their risk for cardiovascular disease. Conventional therapies are ineffective for managing cardiometabolic risk in this patient population, highlighting the need for further research and understanding.
Review
Endocrinology & Metabolism
Aaron R. Cox, Natasha Chernis, Peter M. Masschelin, Sean M. Hartig
Article
Gastroenterology & Hepatology
Kang Ho Kim, Jong Min Choi, Feng Li, Bingning Dong, Clavia Ruth Wooton-Kee, Armando Arizpe, Sayeepriyadarshini Anakk, Sung Yun Jung, Sean M. Hartig, David D. Moore
HEPATOLOGY COMMUNICATIONS
(2019)
