The Road to Approval: a Perspective on the Role of Icosapent Ethyl in Cardiovascular Risk Reduction
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Title
The Road to Approval: a Perspective on the Role of Icosapent Ethyl in Cardiovascular Risk Reduction
Authors
Keywords
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Journal
Current Diabetes Reports
Volume 20, Issue 11, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-10-23
DOI
10.1007/s11892-020-01343-7
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Note: Only part of the references are listed.- Eicosapentaenoic acid (EPA) has optimal chain length and degree of unsaturation to inhibit oxidation of small dense LDL and membrane cholesterol domains as compared to related fatty acids in vitro
- (2020) Samuel C.R. Sherratt et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Emerging Mechanisms of Cardiovascular Protection for the Omega-3 Fatty Acid Eicosapentaenoic Acid
- (2020) R. Preston Mason et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Clinical Management of Stable Coronary Artery Disease in Patients With Type 2 Diabetes Mellitus: A Scientific Statement From the American Heart Association
- (2020) Suzanne V. Arnold et al. CIRCULATION
- Targeting cardiovascular inflammation: next steps in clinical translation
- (2020) Patrick R Lawler et al. EUROPEAN HEART JOURNAL
- Effect of Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients with Elevated Triglycerides on Statin Therapy: A prospective, placebo-controlled randomized trial (EVAPORATE): Interim Results
- (2020) Matthew J Budoff et al. CARDIOVASCULAR RESEARCH
- 4-LB: Substantial Cardiovascular Benefit from Icosapent Ethyl in Patients with Diabetes: REDUCE-IT DIABETES
- (2020) DEEPAK L. BHATT et al. DIABETES
- Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial
- (2020) Matthew J Budoff et al. EUROPEAN HEART JOURNAL
- New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease
- (2019) R. Preston Mason Current Atherosclerosis Reports
- Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
- (2019) Magnus Bäck et al. Nature Reviews Cardiology
- Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT
- (2019) Deepak L. Bhatt et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Generalizability of the REDUCE-IT Trial in Patients With Stable Coronary Artery Disease
- (2019) Fabien Picard et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- REDUCE-IT
- (2019) Deepak L Bhatt EUROPEAN HEART JOURNAL
- 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
- (2019) François Mach et al. EUROPEAN HEART JOURNAL
- Reduction in First and Total Ischemic Events With Icosapent Ethyl Across Baseline Triglyceride Tertiles
- (2019) Deepak L. Bhatt et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- REDUCE-IT USA: Results from the 3,146 Patients Randomized in the United States
- (2019) Deepak L. Bhatt et al. CIRCULATION
- Cardiovascular risk reduction with icosapent ethyl
- (2019) Parth N. Patel et al. CURRENT OPINION IN CARDIOLOGY
- Real-world risk of cardiovascular outcomes associated with hypertriglyceridaemia among individuals with atherosclerotic cardiovascular disease and potential eligibility for emerging therapies
- (2019) Patrick R Lawler et al. EUROPEAN HEART JOURNAL
- National Lipid Association Scientific Statement on the use of icosapent ethyl in statin-treated patients with elevated triglycerides and high or very-high ASCVD risk
- (2019) Carl E. Orringer et al. Journal of Clinical Lipidology
- 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2020
- (2019) DIABETES CARE
- Profound reductions in first and total cardiovascular events with icosapent ethyl in the REDUCE-IT trial: why these results usher in a new era in dyslipidaemia therapeutics
- (2019) William E Boden et al. EUROPEAN HEART JOURNAL
- Eicosapentaenoic acid improves endothelial function and nitric oxide bioavailability in a manner that is enhanced in combination with a statin
- (2018) R. Preston Mason et al. BIOMEDICINE & PHARMACOTHERAPY
- Unmet Need for Adjunctive Dyslipidemia Therapy in Hypertriglyceridemia Management
- (2018) Om P. Ganda et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial
- (2018) Stephen J. Nicholls et al. CLINICAL CARDIOLOGY
- Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus
- (2018) NEW ENGLAND JOURNAL OF MEDICINE
- Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids
- (2018) Reheman Adili et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol
- (2018) Scott M. Grundy et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer
- (2018) JoAnn E. Manson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
- (2018) Deepak L. Bhatt et al. NEW ENGLAND JOURNAL OF MEDICINE
- A randomized controlled trial of eicosapentaenoic acid in patients with coronary heart disease on statins
- (2017) Tetsu Watanabe et al. Journal of Cardiology
- In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi
- (2017) Reheman Adili et al. PLATELETS
- Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes
- (2016) R. Preston Mason et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Effects of the Addition of Eicosapentaenoic Acid to Strong Statin Therapy on Inflammatory Cytokines and Coronary Plaque Components Assessed by Integrated Backscatter Intravascular Ultrasound
- (2016) Toshiyuki Niki et al. CIRCULATION JOURNAL
- Pharmacological Targeting of the Atherogenic Dyslipidemia Complex: The Next Frontier in CVD Prevention Beyond Lowering LDL Cholesterol
- (2016) Changting Xiao et al. DIABETES
- Eicosapentaenoic acid inhibits glucose-induced membrane cholesterol crystalline domain formation through a potent antioxidant mechanism
- (2015) R. Preston Mason et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Impact of Eicosapentaenoic Acid Treatment on the Fibrous Cap Thickness in Patients with Coronary Atherosclerotic Plaque: An Optical Coherence Tomography Study
- (2015) Takashi Yamano et al. Journal of Atherosclerosis and Thrombosis
- Effects of omega-3 carboxylic acids on lipoprotein particles and other cardiovascular risk markers in high-risk statin-treated patients with residual hypertriglyceridemia: a randomized, controlled, double-blind trial
- (2015) Richard L. Dunbar et al. Lipids in Health and Disease
- Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality
- (2015) Gregory A. Roth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Stabilizing effect of combined eicosapentaenoic acid and statin therapy on coronary thin-cap fibroatheroma
- (2014) Ryo Nishio et al. ATHEROSCLEROSIS
- Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients
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- Icosapent Ethyl, a Pure Ethyl Ester of Eicosapentaenoic Acid: Effects on Circulating Markers of Inflammation from the MARINE and ANCHOR Studies
- (2013) Harold E. Bays et al. American Journal of Cardiovascular Drugs
- Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: The EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial
- (2013) John J.P. Kastelein et al. Journal of Clinical Lipidology
- Efficacy and Safety of Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Statin-Treated Patients With Persistent High Triglycerides (from the ANCHOR Study)
- (2012) Christie M. Ballantyne et al. AMERICAN JOURNAL OF CARDIOLOGY
- Effect of Dietary Fish Oil on Atrial Fibrillation After Cardiac Surgery
- (2011) Aaron L. Farquharson et al. AMERICAN JOURNAL OF CARDIOLOGY
- Eicosapentaenoic Acid Ethyl Ester (AMR101) Therapy in Patients With Very High Triglyceride Levels (from the Multi-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension [MARINE] Trial)
- (2011) Harold E. Bays et al. AMERICAN JOURNAL OF CARDIOLOGY
- Omega-3 Fatty Acids and Cardiovascular Disease
- (2011) Dariush Mozaffarian et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction
- (2010) Bernhard Rauch et al. CIRCULATION
- Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human atrial electrophysiology
- (2010) Saurabh Kumar et al. HEART RHYTHM
- Treatment of Aspirin-Resistant Patients With Omega-3 Fatty Acids Versus Aspirin Dose Escalation
- (2010) Eli I. Lev et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effects of Polyunsaturated Omega-3 Fatty Acids on Responsiveness to Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention
- (2010) Grzegorz Gajos et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- n–3 Fatty Acids and Cardiovascular Events after Myocardial Infarction
- (2010) Daan Kromhout et al. NEW ENGLAND JOURNAL OF MEDICINE
- Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
- (2010) NEW ENGLAND JOURNAL OF MEDICINE
- Omega-3 Fatty Acid Supplementation Does Not Reduce Risk of Atrial Fibrillation After Coronary Artery Bypass Surgery
- (2009) Palaniappan Saravanan et al. Circulation-Arrhythmia and Electrophysiology
- Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators
- (2009) I. A. Brouwer et al. EUROPEAN HEART JOURNAL
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