Article
Neurosciences
Josue Jaramillo-Polanco, Cintya Lopez-Lopez, Yang Yu, Emma Neary, Alan Hegron, Meritxell Canals, Nigel W. Bunnett, David E. Reed, Alan E. Lomax, Stephen J. Vanner
Summary: This study found that chronic high-dose opioid exposure leads to opioid-induced hyperalgesia (OIH) in the gastrointestinal tract, which is mediated by DOPr signaling and dependent on receptor endocytosis and protein kinase C signaling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Hongwei Cai, Zheng Ao, Chunhui Tian, Zhuhao Wu, Connor Kaurich, Zi Chen, Mingxia Gu, Andrea G. Hohmann, Ken Mackie, Feng Guo
Summary: Opioids may induce tolerance and hyperalgesia, but the human mechanisms underlying these effects are not well understood. Researchers have developed a novel human spinal microphysiological system (MPS) to model human nociception and opioid-induced tolerance. This system shows promising potential for studying pain etiology, screening new treatments, and validating novel therapeutics for human pain medicine.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Rob Hill, Meritxell Canals
Summary: Morphine and other opioids are widely used for pain treatment, but their side effects limit their use. Developing opioids with fewer side effects is a major research focus, but translating promising candidates from the lab to the clinic remains challenging.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Chemistry, Medicinal
Alok K. Paul, Craig M. Smith, Mohammed Rahmatullah, Veeranoot Nissapatorn, Polrat Wilairatana, Mariana Spetea, Nuri Gueven, Nikolas Dietis
Summary: Opioids are commonly used for pain management but have numerous adverse effects, particularly in older adults. Understanding the mechanisms of opioid-induced adverse reactions can aid in improving pain management strategies.
Article
Behavioral Sciences
Jacob M. Green, Mark H. Sundman, Ying-Hui Chou
Summary: Opioid-induced microglia reactivity can affect opioid reward and analgesic processes, leading to neurocognitive impairment in opioid addicted individuals. These effects are mediated by opioid metabolites acting on TLR4 receptors, resulting in increased release of inflammatory molecules. The resulting imbalance between the impulsive and executive systems may contribute to addiction-related behaviors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Medicine, General & Internal
Mia Elena Koponen, Patrice Forget
Summary: This study aimed to investigate pharmacological interventions for opioid-induced hyperalgesia caused by different opioids. The majority of interventions were studied in only one trial, with the most common mechanism being the inhibition of N-methyl-D-aspartate (NMDA) receptors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Mark Moran, Kenneth Blum, Jessica Valdez Ponce, Lisa Lott, Marjorie C. Gondre-Lewis, Sampada Badgaiyan, Raymond Brewer, B. William Downs, Philip Fynman, Alexander Weingarten, Jean Lud Cadet, David E. Smith, David Baron, Panayotis K. Thanos, Edward J. Modestino, Rajendra D. Badgaiyan, Igor Elman, Mark S. Gold
Summary: The study reveals that chronic opioid users attending a pain clinic have a high genetic risk for drug and alcohol addiction. Specific genetic testing can predict the severity of drug and alcohol dependence, aiding in the early identification of genetic risk.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karen R. Thomas, Jacob Watt, Chuen Mong J. Wu, Adejoke Akinrinoye, Sairah Amjad, Lucy Colvin, Rachel Cowe, Sylvia H. Duncan, Wendy R. Russell, Patrice Forget
Summary: Opioid use can lead to dysbiosis in the gut microbiome, impacting mental health and potentially leading to conditions such as depression and Parkinson's Disease. Therapeutic interventions, including fecal microbiota transplantation and targeted antibiotic therapy, can influence the gut microbiome and potentially alleviate the effects of opioid-induced dysbiosis.
Article
Anesthesiology
Xin Liu, Bo-Long Liu, Qing Yang, Xiangfu Zhou, Shao-Jun Tang
Summary: Long-term use of opioid analgesics leads to paradoxical pain, where microglia were previously believed to play a critical role. However, experiments showed that ablating microglia did not cause detectable impairment in the expression of hyperalgesia induced by opioids.
Article
Anesthesiology
Markus Dieterle, Laura Zurbriggen, Eckhard Mauermann, Katja Mercer-Chalmers-Bender, Priska Frei, Wilhelm Ruppen, Tobias Schneider
Summary: This study suggests that a high single-oral dose of 1600 mg cannabidiol is not effective in reducing opioid-induced hyperalgesia (OIH).
Review
Pharmacology & Pharmacy
Wei-Ji Xie, Ji-Shuang Hong, Cheng-Fei Feng, Hao-Feng Chen, Wei Li, Yong-Chun Li
Summary: This study conducted a network meta-analysis to compare different pharmacological interventions for preventing the increase in postoperative pain intensity caused by opioid-induced hyperalgesia (OIH). The results showed that amantadine was the most effective drug in controlling postoperative pain intensity, while dexmedetomidine outperformed placebo in all indicators.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Emilie Laboureyras, Meric Ben Boujema, Annie Mauborgne, John Simmers, Michel Pohl, Guy Simonnet
Summary: The study found that opioids used for pain management can lead to tolerance and hyperalgesia, with an overactivation of the spinal N-methyl-(D)-aspartate receptor-inducible NO synthase cascade playing a critical role in both phenomena.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Anesthesiology
Ryu Komatsu, Michael Nash, Shane Mandalia, Emily Dinges, Umar Kamal, Davin Singh, Hani El-Omrani, Anjum Anwar, Carlos Delgado, Taylor M. Ziga, Brendan Carvalho
Summary: This study aimed to predict opioid consumption and pain intensity after cesarean delivery. The results showed that previous opioid consumption and pain scores had weak predictive ability for opioid consumption and pain after the index cesarean delivery.
ANESTHESIA AND ANALGESIA
(2022)
Article
Medicine, Research & Experimental
Yaoyuan Li, Yanju Bao, Honggang Zheng, Yinggang Qin, Baojin Hua
Summary: The clinical application of opioids may lead to adverse consequences, but Src inhibitors have the potential to alleviate these issues and can be used in combination with opioids to achieve synergy. Maximizing the analgesic effect while avoiding unnecessary trouble provides a topic for future research.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Anesthesiology
Bin Shu, Huiting Liu, Xuemei Zheng, Jianrong He, Yingcai Wu, Jie Chen, Yuanjing Chen, Hongni Tian, Dapeng Ju, He Huang, Guangyou Duan
Summary: The time of day at which opioids are administered may impact pain sensitivity, pain severity, and drug concentration levels.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Clinical Neurology
Lauren K. Dunn, Bhiken I. Naik, Edward C. Nemergut, Marcel E. Durieux
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2016)
Review
Anesthesiology
Lauren K. Dunn, Marcel E. Durieux, W. Jeffrey Elias, Edward C. Nemergut, Bhiken I. Naik
JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY
(2018)
Article
Anesthesiology
Abdullah S. Terkawi, Siny Tsang, Ali Kazemi, Steve Morton, Roy Luo, Daniel T. Sanders, Lindsay A. Regali, Heather Columbano, Nicole Y. Kurtzeborn, Marcel E. Durieux
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2016)
Article
Critical Care Medicine
Bhiken I. Naik Mbbch, Douglas A. Colquhoun, Isaac A. Shields, Russell E. Davenport, Marcel E. Durieux, Randal S. Blank
JOURNAL OF CRITICAL CARE
(2017)
Article
Cardiac & Cardiovascular Systems
Jacob Raphael, Stephen R. Collins, Xin-Qun Wang, David C. Scalzo, Priyanka Singla, Christine L. Lau, Benjamin D. Kozower, Marcel. E. Durieux, Randal S. Blank
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2017)
Article
Anesthesiology
Kevin C. Greer, Abdullah S. Terkawi, Siny Tsang, Priyanka Singla, Marcel E. Durieux, Mohamed Tiouririne
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2017)
Article
Anesthesiology
Bhiken I. Naik, Siny Tsang, Anne Knisely, Sandeep Yerra, Marcel E. Durieux
BMC ANESTHESIOLOGY
(2017)
Article
Anesthesiology
Douglas A. Colquhoun, Bhiken I. Naik, Marcel E. Durieux, Amy M. Shanks, Sachin Kheterpal, S. Patrick Bender, Randal S. Blank
ANESTHESIA AND ANALGESIA
(2018)
Article
Anesthesiology
Sunny S. Chiao, Douglas A. Colquhoun, Bhiken I. Naik, Jennie Z. Ma, Edward C. Nemergut, Marcel E. Durieux, Randal S. Blank, Katherine T. Forkin
ANESTHESIA AND ANALGESIA
(2018)
Article
Anesthesiology
Lauren K. Dunn, Sandeep Yerra, Shenghao Fang, Mark F. Hanak, Maren K. Leibowitz, Siny Tsang, Marcel E. Durieux, Edward C. Nemergut, Bhiken I. Naik
ANESTHESIA AND ANALGESIA
(2018)
Article
Clinical Neurology
Lauren K. Dunn, Marcel E. Durieux, Lucas G. Fernandez, Siny Tsang, Emily E. Smith-Straesser, Hasan F. Jhaveri, Shauna P. Spanos, Matthew R. Thames, Christopher D. Spencer, Aaron Lloyd, Russell Stuart, Fan Ye, Jacob P. Bray, Edward C. Nemergut, Bhiken I. Naik
JOURNAL OF NEUROSURGERY-SPINE
(2018)
Letter
Anesthesiology
Lauren K. Dunn, Marcel E. Durieux
Article
Anesthesiology
Lauren K. Dunn, Marcel E. Durieux
Letter
Anesthesiology
Bhiken I. Naik, Edward C. Nemergut, Marcel E. Durieux
Article
Anesthesiology
Karen E. Singh, Benjamin Hirsch, Douglas Colquhoun, Marcel Durieux
A & A CASE REPORTS
(2016)
