Sex differences in innate immunity and its impact on opioid pharmacology

Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms

(2016) Harald Engler et al.   BRAIN BEHAVIOR AND IMMUNITY

Sex Differences in GABA A Signaling in the Periaqueductal Gray Induced by Persistent Inflammation

(2016) Karen J. Tonsfeldt et al.   JOURNAL OF NEUROSCIENCE

Toll-like Receptor 4 Mediates Morphine-Induced Neuroinflammation and Tolerance via Soluble Tumor Necrosis Factor Signaling

(2016) Lori N Eidson et al.   NEUROPSYCHOPHARMACOLOGY

Modality and sex differences in pain sensitivity during human endotoxemia

(2015) B. Karshikoff et al.   BRAIN BEHAVIOR AND IMMUNITY

Contribution of Endogenous Spinal Endomorphin 2 to Intrathecal Opioid Antinociception in Rats Is Agonist Dependent and Sexually Dimorphic

(2015) Arjun Kumar et al.   JOURNAL OF PAIN

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Estrogens Suppress Spinal Endomorphin 2 Release in Female Rats in Phase with the Estrous Cycle

(2015) Arjun Kumar et al.   NEUROENDOCRINOLOGY

Spinal and supraspinal N-methyl-d-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia

(2015) Caroline A. Arout et al.   PHYSIOLOGY & BEHAVIOR

Sex Differences in Peripheral Mu-Opioid Receptor Mediated Analgesia in Rat Orofacial Persistent Pain Model

(2015) Xiaofeng Bai et al.   PLoS One

Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration

(2014) Mrinmay Chakrabarti et al.   BRAIN RESEARCH BULLETIN

Descending modulation of pain: the GABA disinhibition hypothesis of analgesia

(2014) Benjamin K Lau et al.   CURRENT OPINION IN NEUROBIOLOGY

The neuroanatomy of sexual dimorphism in opioid analgesia

(2014) Dayna R. Loyd et al.   EXPERIMENTAL NEUROLOGY

Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C

(2014) Xisheng Yan et al.   GLIA

Chronic Estradiol Administration In Vivo Promotes the Proinflammatory Response of Macrophages to TLR4 Activation: Involvement of the Phosphatidylinositol 3-Kinase Pathway

(2014) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

Prevalence of Persistent Pain in the U.S. Adult Population: New Data From the 2010 National Health Interview Survey

(2014) Jae Kennedy et al.   JOURNAL OF PAIN

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Primary sensory neurons regulate Toll-like receptor-4-dependent activity of glial cells in dorsal root ganglia

(2014) K.-H. Tse et al.   NEUROSCIENCE

Use of non-opioid analgesics as adjuvants to opioid analgesia for cancer pain management in an inpatient palliative unit: does this improve pain control and reduce opioid requirements?

(2014) Shivani Shinde et al.   SUPPORTIVE CARE IN CANCER

Toll-like receptor 4-mediated nuclear factor-κB activation in spinal cord contributes to chronic morphine-induced analgesic tolerance and hyperalgesia in rats

(2014) Liying Bai et al.   Neuroscience Bulletin

The Efficacy of Oral Celecoxib for Acute Postoperative Pain in Face-lift Surgery

(2014) Behrad B. Aynehchi et al.   JAMA Facial Plastic Surgery

Sex differences in μ-opioid receptor expression in trigeminal ganglia under a myositis condition in rats

(2013) X. Zhang et al.   EUROPEAN JOURNAL OF PAIN

Sex Differences in the Prevalence, Symptoms, and Associated Features of Migraine, Probable Migraine and Other Severe Headache: Results of the American Migraine Prevalence and Prevention (AMPP) Study

(2013) Dawn C. Buse et al.   HEADACHE

Blockade of Toll-Like Receptor 4 Attenuates Morphine Tolerance and Facilitates the Pain Relieving Properties of Morphine

(2013) L. N. Eidson et al.   JOURNAL OF NEUROSCIENCE

Persistent Peripheral Inflammation Attenuates Morphine-Induced Periaqueductal Gray Glial Cell Activation and Analgesic Tolerance in the Male Rat

(2013) Lori N. Eidson et al.   JOURNAL OF PAIN

Spinal Endomorphin 2 Antinociception and the Mechanisms That Produce It Are Both Sex- and Stage of Estrus Cycle–Dependent in Rats

(2013) Nai-Jiang Liu et al.   JOURNAL OF PAIN

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Mu opioid receptor activation modulates Toll like receptor 4 in murine macrophages

(2012) Silvia Franchi et al.   BRAIN BEHAVIOR AND IMMUNITY

The prevalence of chronic pain with an analysis of countries with a Human Development Index less than 0.9: a systematic review without meta-analysis

(2012) Raga A. Elzahaf et al.   CURRENT MEDICAL RESEARCH AND OPINION

Sex, glia, and development: Interactions in health and disease

(2012) Jaclyn M. Schwarz et al.   HORMONES AND BEHAVIOR

Sex Differences in Reported Pain Across 11,000 Patients Captured in Electronic Medical Records

(2012) David Ruau et al.   JOURNAL OF PAIN

Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance

(2012) Qian Li   MEDICAL HYPOTHESES

Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon

(2012) Jeffrey S. Mogil   NATURE REVIEWS NEUROSCIENCE

Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats

(2012) Lisa C. Loram et al.   PSYCHONEUROENDOCRINOLOGY

Toll-like receptors in chronic pain

(2011) Lauren Nicotra et al.   EXPERIMENTAL NEUROLOGY

Expression of N-methyl D-aspartate receptor subunits in amoeboid microglia mediates production of nitric oxide via NF-κB signaling pathway and oligodendrocyte cell death in hypoxic postnatal rats

(2011) Madhuvika Murugan et al.   GLIA

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus

(2010) Grzegorz A. Czapski et al.   BRAIN RESEARCH

Can we explain the higher prevalence of autoimmune disease in women?

(2010) Shaye Kivity et al.   Expert Review of Clinical Immunology

17 -Estradiol Promotes TLR4-Triggered Proinflammatory Mediator Production through Direct Estrogen Receptor   Signaling in Macrophages In Vivo

(2010) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies

(2010) Marieke Niesters et al.   PAIN

Progesterone rapidly recruits female-typical opioid-induced hyperalgesic mechanisms

(2010) Amanda R. Waxman et al.   PHYSIOLOGY & BEHAVIOR

Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor

(2009) Aaron Juni et al.   ANESTHESIOLOGY

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

(2009) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Estrogens Augment Cell Surface TLR4 Expression on Murine Macrophages and Regulate Sepsis Susceptibilityin Vivo

(2009) Jennifer A. Rettew et al.   ENDOCRINOLOGY

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Women's health and gender-based clinical trials on etoricoxib: methodological gender bias

(2009) E. Chilet-Rosell et al.   JOURNAL OF PUBLIC HEALTH

Drug dependent sex-differences in periaqueducatal gray mediated antinociception in the rat

(2009) Erin N. Bobeck et al.   PAIN

Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers

(2009) Sandra D. Comer et al.   PSYCHOPHARMACOLOGY

The “Toll” of Opioid-Induced Glial Activation: Improving the Clinical Efficacy of Opioids by Targeting Glia

(2009) Linda R. Watkins et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females: Are the Anatomy and Physiology Really that Different?

(2009) Dayna R. Loyd et al.   NEURAL PLASTICITY

Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

(2008) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Sexually dimorphic activation of the periaqueductal gray–rostral ventromedial medullary circuit during the development of tolerance to morphine in the rat

(2008) Dayna R. Loyd et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats

(2008) Megan Ryan Detloff et al.   EXPERIMENTAL NEUROLOGY

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats

(2008) Danielle K. Lewis et al.   JOURNAL OF NEUROIMMUNOLOGY

Sex Differences in  -Opioid Receptor Expression in the Rat Midbrain Periaqueductal Gray Are Essential for Eliciting Sex Differences in Morphine Analgesia

(2008) D. R. Loyd et al.   JOURNAL OF NEUROSCIENCE

Supraspinal Glial-Neuronal Interactions Contribute to Descending Pain Facilitation

(2008) F. Wei et al.   JOURNAL OF NEUROSCIENCE

Pathological and protective roles of glia in chronic pain

(2008) Erin D. Milligan et al.   NATURE REVIEWS NEUROSCIENCE

Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain

(2008) H. Zhang et al.   NEUROSCIENCE

The pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) from 1997 to 2005: a nationwide study on 4.6 million people

(2008) Emil Loldrup Fosbøl et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats

(2007) Rebecca M. Craft et al.   EUROPEAN JOURNAL OF PAIN