Article
Chemistry, Applied
Meng Wang, Yun-Cheng Li, Fan-Bing Meng, Qiao Wang, Zheng-Wu Wang, Da-Yu Liu
Summary: In this study, honeysuckle leaf extract was added to the CMKH composite film. The addition of honeysuckle leaf extract slightly decreased the water vapor barrier properties of the film, but completely blocked UV transmission. The film with honeysuckle leaf extract showed higher elongation at break and exhibited strong antioxidant and antimicrobial activities.
Article
Food Science & Technology
Lin Wang, Ning Zhou, Shengxuan Zheng, Jie Pang
Summary: This study reports a composite hydrogel composed of multiple biocompatible materials, which exhibits good biodegradability and pH sensitivity. The incorporation of functional nano-hydroxyapatite improves the physico-chemical properties of the hydrogel. The study demonstrates that the hydrogel has enhanced drug release, biocompatibility, and encapsulation properties.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Chun-Ye Gu, Xin-Ru Zhang, Guo-Qing Huang, Xin Geng, Jun-Xia Xiao
Summary: Lysozyme and carboxymethyl konjac glucomannan (CMKGM) can form dispersible coacervates, which can be used in edible antibacterial coating. The interaction between lysozyme and CMKGM occurs at pH 2.5 to 6.0 and at 35°C without NaCl. The dispersion status of the coacervates is influenced by the phase separation pH and the ratio of lysozyme to CMKGM.
Article
Chemistry, Applied
Shikai Zhang, Ziyang He, Fangzhou Xu, Yue Cheng, Geoffrey I. N. Waterhouse, Dongxiao Sun-Waterhouse, Peng Wu
Summary: The addition of ZPEO in KGM films can modify their properties, leading to high-performance composite films with enhanced tensile strength, water contact angle, and antibacterial properties, as well as the ability to slowly release essential oils.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Weimin Tang, Yanjun Wei, Wenjing Lu, Di Chen, Qin Ye, Cen Zhang, Yufeng Chen, Chaogeng Xiao
Summary: This study developed an ovalbumin-carboxymethyl konjac glucomannan nano-delivery system to enhance the bioavailability of naringin. The optimized processing parameters resulted in nanoparticles with high encapsulation efficiency and improved bioaccessibility.
Article
Biochemistry & Molecular Biology
Rixiang Su, Wei Su, Jinyun Cai, Lei Cen, Shanshan Huang, Yu Wang, Peiyuan Li
Summary: In this study, a nanocomposite drug was developed to overcome the limitations of photo-sensitizers and form composite films with improved stability and mechanical properties. The nanocomposite drug showed good biocompatibility and PDT antibacterial effects, making it a promising nano-antibacterial agent for the treatment of bacterial infections and wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Li Yan, Xugang Dang, Mao Yang, Wenjia Han, Yanchun Li
Summary: In this research, dialdehyde carboxymethyl cellulose was modified to synthesize hyperbranched dialdehyde carboxymethyl cellulose. A novel film was then obtained by grafting gelatin onto the hyperbranched dialdehyde carboxymethyl cellulose. The prepared film showed good thermal stability, mechanical properties, cytocompatibility, and antibacterial properties.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Food Science & Technology
Luhui Wang, Xinru Zhang, Junxia Xiao, Jiayi Shi
Summary: The stability of curcumin-loaded secondary and tertiary emulsions, stabilized by whey protein isolate (WPI) and coated with chitosan (CHI), carboxymethyl konjac glucomannan (CMKGM), or their combination, was investigated. Electrostatic interaction played an important role in the stability of the emulsions, and extra coating with CHI and CMKGM improved the stability and retention of curcumin against environmental stresses. The multilayered emulsions, especially the tertiary emulsion with CMKGM in the outermost layer, could be used as an effective carrier for targeted delivery of curcumin.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Gaiying Li, Yongchao Jiang, Mengya Li, Wenjie Zhang, Qian Li, Keyong Tang
Summary: In this study, oxidized konjac glucomannan (OKG) with different molecular weights were used as polysaccharide crosslinker to reinforce gelatin-based hydrogels. The results indicated that higher molecular weight OKG increased the mechanical strength and self-healing ability of the composite hydrogels, as well as promoted cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Chunhua Wu, Jishuai Sun, Haixin Jiang, Yuanzhao Li, Jie Pang
Summary: Novel carboxymethyl konjac glucomannan/chitosan (CMKGM/CS) nanogels with and without crosslinking were prepared for curcumin delivery, showing enhanced stability and sustained release behavior under gastrointestinal conditions. The crosslinked nanogels had higher encapsulation efficiency of curcumin compared to uncrosslinked nanogels.
Article
Food Science & Technology
Yinghua Luo, Yanbei Wu, Yali Wang, Liangli (Lucy) Yu
Summary: A facile strategy was proposed to prepare a strong and active gelatin-based film (GBF) by incorporating gallic acid and microfibrillated cellulose, leading to improved mechanical properties and enhanced water vapor barrier and antioxidant activity. The introduction of aromatic structure of GA and nano-/microfibrils in MFC also enhanced UV blocking performance and thermal stability of the films, showing great potential for active and safe food packaging materials.
Article
Chemistry, Applied
Yongsheng Ni, Jing Sun, Jianlong Wang
Summary: This paper presents a new strategy for developing konjac glucomannan-based antibacterial films with a broad-spectrum antibacterial activity. The films, incorporating CNMo nanocomposites, show excellent performances in terms of structural, mechanical, and thermal properties, as well as hydrophobicity, prolonging the shelf life of cherry tomatoes. Hemolysis and cells experiment confirm the safety of the film, indicating potential applications in antibacterial packaging.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Hongyi Wu, Nitong Bu, Jie Chen, Yuanyuan Chen, Runzhi Sun, Chunhua Wu, Jie Pang
Summary: The study showed that oxidized hyaluronic acid (OHA) can effectively improve the properties and control release characteristics of KGM hydrogels. Increasing the concentration of OHA can enhance the swelling capacity and rheological properties of the composite hydrogels. The cumulative release rate of epigallocatechin gallate (EGCG) in KGM/OHA composite hydrogels is enhanced with the increasing addition of OHA.
Article
Biochemistry & Molecular Biology
Peiqiong You, Lin Wang, Ning Zhou, Ying Yang, Jie Pang
Summary: This study found that adding blackcurrant anthocyanins (BCA) to konjac glucomannan (KGM)/carboxymethyl cellulose (CMC) composite film can improve its structure and properties. The composite film has higher thermal stability and antioxidant and antibacterial properties, and can inhibit food-borne pathogens. Furthermore, the composite film can be used for real-time monitoring of meat product quality.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Liang, Qinyue Zheng, Zhenjun Liu, Guohua Zhao, Yun Zhou
Summary: A facile post-gelation soaking strategy was investigated in this study to produce low-alkaline konjac glucomannan (KGM) gels. The process involved soaking alkali-induced gels in citric acid (CA) solutions, which successfully reduced the gel pH and improved the texture and flavor of the gels. The whiteness of the gels increased and the volume decreased after post-soaking treatment, but these differences became less apparent after long-term storage. The water holding capacity and syneresis of the low-alkaline KGM gels were not significantly affected by the soaking process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Chunhua Wu, Yuanzhao Li, Yu Du, Lin Wang, Cailing Tong, Yaqin Hu, Jie Pang, Zhiming Yan
FOOD HYDROCOLLOIDS
(2019)
Article
Biochemistry & Molecular Biology
Wanmei Lin, Yongsheng Ni, Lin Wang, Dengyi Liu, Chunhua Wu, Jie Pang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Lin Wang, Ruo-Jun Mu, Lizhuan Lin, Xiaohan Chen, Sisi Lin, Qianwen Ye, Jie Pang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Yu Du, Lin Wang, Ruojun Mu, Yuyan Wang, Yuanzhao Li, Dan Wu, Chunhua Wu, Jie Pang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Jishuai Sun, Yu Du, Jiaqi Ma, Yuanzhao Li, Lin Wang, Yinzhu Lu, Junwu Zou, Jie Pang, Chunhua Wu
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Food Science & Technology
Lin Wang, Ruo-Jun Mu, Yuanzhao Li, Lizhuan Lin, Zheya Lin, Jie Pang
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
Article
Chemistry, Applied
Chunhua Wu, Yaoling Li, Jishuai Sun, Yinzhu Lu, Cailing Tong, Lin Wang, Zhiming Yan, Jie Pang
FOOD HYDROCOLLOIDS
(2020)
Article
Chemistry, Applied
Lin Wang, Yuanzhao Li, Lizhun Lin, Ruojun Mu, Jie Pang
CARBOHYDRATE POLYMERS
(2020)
Article
Chemistry, Applied
Lin Wang, Lizhuan Lin, Yangyang Guo, Jie Long, Ruo-Jun Mu, Jie Pang
FOOD HYDROCOLLOIDS
(2020)
Article
Biochemistry & Molecular Biology
Cailing Tong, Zhiqin Wu, Jishuai Sun, Lizhuan Lin, Lin Wang, Yangyang Guo, Zhoncai Huang, Chunhua Wu, Jie Pang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biotechnology & Applied Microbiology
Zhifeng Wen, Jinhui Bai, Lin Wang, Liping Yao, Bilal Ahmad, Muhammad Hanif, Qingxi Chen
PLANT BIOTECHNOLOGY REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Ning Zhou, Lin Wang, Peiqiong You, Liangyu Wang, RuoJun Mu, Jie Pang
Summary: A pH-sensitive food packaging film was developed based on konjac glucomannan and hydroxypropyl methyl cellulose incorporated with mulberry extracts, exhibiting improved mechanical properties, UV resistance, and antioxidant and antibacterial properties. The film showed good responsiveness to pH buffers and real-time monitoring of fish freshness through color changes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Yangyang Guo, Ruojun Mu, Lin Wang, Jie Pang
Summary: This paper explores the strategy of synthesizing nanofibril film using KGM and PEO, demonstrating superior physical and chemical properties compared to solvent casting film. By adjusting the ratio of KGM to PEO, a nanofibril film with consistent size and good performance is produced. Characterization with FT-IR and XRD reveals physical crosslinked networks and polymer crystallization modifications in the nanofibril film. Additionally, the integration of GSE into the electrospinning solutions results in a bioactive nanofibril film with water vapor barrier and antioxidation functions.
Article
Food Science & Technology
Lei Pan, Lin Wang, Fan Zhang, Yi Zhang, Baodong Zheng
Summary: Polysaccharide fractions were extracted from Dictyophora indusiata, and their structure and bifidogenic activity were investigated. It was found that DIP0 promoted the growth of Bifidobacterium longum and its metabolic synthesis of acetic acid during fermentation.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
