Spectroscopy integration to miniature bioreactors and large scale production bioreactors–Increasing current capabilities and model transfer

Sustainability in the biopharmaceutical industry: Seeking a holistic perspective

(2019) Fergal Lalor et al.   BIOTECHNOLOGY ADVANCES

A novel scale‐down mimic of perfusion cell culture using sedimentation in an automated microbioreactor (SAM)

(2019) Steffen Kreye et al.   BIOTECHNOLOGY PROGRESS

Real‐time quantification and supplementation of bioreactor amino acids to prolong culture time and maintain antibody product quality

(2019) David N. Powers et al.   BIOTECHNOLOGY PROGRESS

Systematic evaluation of high-throughput scale-down models for single-use bioreactors (SUB) using volumetric gas flow rate as the criterion

(2019) Xiaolin Zhang et al.   BIOCHEMICAL ENGINEERING JOURNAL

Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale‐Up Model Validation and Missing Data on a Micro‐Bioreactor System

(2019) Stephen Goldrick et al.   Biotechnology Journal

Interest of locally weighted regression to overcome nonlinear effects during in situ NIR monitoring of CHO cell culture parameters and antibody glycosylation

(2019) Daniel A. Zavala‐Ortiz et al.   BIOTECHNOLOGY PROGRESS

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

Development of generic raman models for a GS-KOTM CHO platform process

(2018) Thaddaeus A. Webster et al.   BIOTECHNOLOGY PROGRESS

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

At‐line raman spectroscopy and design of experiments for robust monitoring and control of miniature bioreactor cultures

(2018) Ruth C. Rowland‐Jones et al.   BIOTECHNOLOGY PROGRESS

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Spectroscopic methods and their applicability for high-throughput characterization of mammalian cell cultures in automated cell culture systems

(2016) Carsten Musmann et al.   ENGINEERING IN LIFE SCIENCES

Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

(2015) Brandon N. Berry et al.   BIOTECHNOLOGY PROGRESS

Human cell lines for biopharmaceutical manufacturing: history, status, and future perspectives

(2015) Jennifer Dumont et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

(2015) Julián López-Meza et al.   CYTOTECHNOLOGY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

A stainless steel multi-well plate (SS-MWP) for high-throughput Raman analysis of dilute solutions

(2010) Alan G. Ryder et al.   JOURNAL OF RAMAN SPECTROSCOPY