Quick generation of Raman spectroscopy based in-process glucose control to influence biopharmaceutical protein product quality during mammalian cell culture

Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

(2015) Hamidreza Mehdizadeh et al.   BIOTECHNOLOGY PROGRESS

A quantitative proteomic analysis of cellular responses to high glucose media in Chinese hamster ovary cells

(2015) Zhenke Liu et al.   BIOTECHNOLOGY PROGRESS

Recombinant Antibody Color Resulting from Advanced Glycation End Product Modifications

(2014) Margaret Butko et al.   ANALYTICAL CHEMISTRY

Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis

(2014) Brandon Berry et al.   BIOTECHNOLOGY PROGRESS

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies

(2014) Markus Haberger et al.   mAbs

Bioreactor monitoring with spectroscopy and chemometrics: a review

(2012) N. D. Lourenço et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Soft sensors in bioprocessing: A status report and recommendations

(2012) Reiner Luttmann et al.   Biotechnology Journal

Minimizing immunogenicity of biopharmaceuticals by controlling critical quality attributes of proteins

(2012) Miranda M. C. van Beers et al.   Biotechnology Journal

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

In situ Raman spectroscopy for simultaneous monitoring of multiple process parameters in mammalian cell culture bioreactors

(2012) Jessica Whelan et al.   BIOTECHNOLOGY PROGRESS

In situ sensor techniques in modern bioprocess monitoring

(2011) Sascha Beutel et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Controlling glycation of recombinant antibody in fed-batch cell cultures

(2011) Inn H. Yuk et al.   BIOTECHNOLOGY AND BIOENGINEERING

Characterization of Site-Specific Glycation During Process Development of a Human Therapeutic Monoclonal Antibody

(2011) Amanda K. Miller et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Process analytical technology (PAT) for biopharmaceutical products

(2010) A. S. Rathore et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Glycation of monoclonal antibodies impairs their ability to bind antigen

(2010) D. M. KENNEDY et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Charge variants in IgG1

(2010) Leslie A. Khawli et al.   mAbs

Advances in on-line monitoring and control of mammalian cell cultures: Supporting the PAT initiative

(2009) A.P. Teixeira et al.   BIOTECHNOLOGY ADVANCES

Maillard Reaction Products in the Escherichia coli-derived Therapeutic Protein Interferon Alfacon-1

(2008) Roumyana Mironova et al.   Annals of the New York Academy of Sciences