Using simple models to describe the kinetics of growth, glucose consumption, and monoclonal antibody formation in naive and infliximab producer CHO cells

In situ product recovery of single-chain antibodies in a membrane bioreactor

(2014) Kristina Meier et al.   BIOTECHNOLOGY AND BIOENGINEERING

Evaluation of a kinetic model for computer simulation of growth and fermentation byScheffersomyces(Pichia) stipitisfedD-xylose

(2014) P. J. Slininger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective

(2014) Alan J Dickson   CURRENT OPINION IN BIOTECHNOLOGY

Amino acid consumption in naïve and recombinant CHO cell cultures: producers of a monoclonal antibody

(2014) L. M. Carrillo-Cocom et al.   CYTOTECHNOLOGY

Operator training in recombinant protein production using a structured simulator model

(2014) Inga Gerlach et al.   JOURNAL OF BIOTECHNOLOGY

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Kinetic models in industrial biotechnology – Improving cell factory performance

(2014) Joachim Almquist et al.   METABOLIC ENGINEERING

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

(2013) Neil Templeton et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dynamic process conditions in bioprocess development

(2013) Oliver Spadiut et al.   ENGINEERING IN LIFE SCIENCES

Lovastatin biosynthesis depends on the carbon-nitrogen proportion: Model development and controller design

(2013) James Gomes et al.   ENGINEERING IN LIFE SCIENCES

Insights of biosimilars through SWOT analysis

(2013) Mayur Mahendrakumar Patel et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Performance improvement ofBacillus aryabhattaiITBHU02 for high-throughput production of a tumor-inhibitory L-asparaginase using a kinetic model based approach

(2013) Yogendra Singh et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Microbials for the production of monoclonal antibodies and antibody fragments

(2013) Oliver Spadiut et al.   TRENDS IN BIOTECHNOLOGY

Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

(2012) Stephen Craven et al.   BIOTECHNOLOGY PROGRESS

Quality by design: Impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody

(2012) David Awotwe-Otoo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Comparison of commercial serum-free media for CHO-K1 cell growth and monoclonal antibody production

(2012) Maria Elisa Rodrigues et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Dynamic metabolic models of CHO cell cultures through minimal sets of elementary flux modes

(2012) F. Zamorano et al.   JOURNAL OF BIOTECHNOLOGY

Development of a Scale-Down Model of hydrodynamic stress to study the performance of an industrial CHO cell line under simulated production scale bioreactor conditions

(2012) Jochen B. Sieck et al.   JOURNAL OF BIOTECHNOLOGY

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

(2012) Francesca Zagari et al.   New Biotechnology

Single-use disposable technologies for biopharmaceutical manufacturing

(2012) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

A comprehensive comparison of mixing, mass transfer, Chinese hamster ovary cell growth, and antibody production using Rushton turbine and marine impellers

(2011) Sandeepa Sandadi et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Use of a Plackett-Burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells

(2011) I. J. González-Leal et al.   BIOTECHNOLOGY PROGRESS

Therapeutic antibodies: Market considerations, disease targets and bioprocessing

(2011) John G. Elvin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cell Engineering and Cultivation of Chinese Hamster Ovary (CHO) Cells

(2010) Takeshi Omasa et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Kinetic analysis and mathematical modeling of growth and lactic acid production of Lactobacillus casei var. rhamnosus in milk whey

(2010) M.M. Alvarez et al.   JOURNAL OF DAIRY SCIENCE

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Robust parameter estimation during logistic modeling of batch and fed-batch culture kinetics

(2009) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS

Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures

(2008) Olivier Henry et al.   BIOTECHNOLOGY PROGRESS

Kinetics of IFN-γ producing CHO cells and other industrially relevant cell lines in rapeseed-supplemented batch cultures

(2008) B. Farges et al.   PROCESS BIOCHEMISTRY

Logistic Equations Effectively Model Mammalian Cell Batch and Fed-Batch Kinetics by Logically Constraining the Fit

(2005) Chetan T. Goudar et al.   BIOTECHNOLOGY PROGRESS