Multivariate Data Analysis Methodology to Solve Data Challenges Related to Scale‐Up Model Validation and Missing Data on a Micro‐Bioreactor System

A heuristic approach to handling missing data in biologics manufacturing databases

(2019) Jeanet Mante et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

An Industrial Perspective on Scale-Down Challenges Using Miniaturized Bioreactors

(2019) Tannaz Tajsoleiman et al.   TRENDS IN BIOTECHNOLOGY

On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

(2018) Stephen Goldrick et al.   Biotechnology Journal

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

Production of monoclonal antibodies in microfluidic devices

(2018) Natalia Bourguignon et al.   Integrative Biology

Staying alive! Sensors used for monitoring cell health in bioreactors

(2018) P. O’Mara et al.   TALANTA

On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

(2018) Stephen Goldrick et al.   Biotechnology Journal

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target

(2018) Michael Sokolov et al.   Biotechnology Journal

A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes

(2018) Bernd Van Snick et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-depth Evaluation of Data Collected During a Continuous Pharmaceutical Manufacturing Process: A Multivariate Statistical Process Monitoring Approach

(2018) Ana F. Silva et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Scale-Down Model Development in ambr systems: An Industrial Perspective

(2018) Viktor Sandner et al.   Biotechnology Journal

Extraction of indirectly captured information for use in a comparison of offline pH measurement technologies

(2017) Elspeth K. Ritchie et al.   JOURNAL OF BIOTECHNOLOGY

Investigation of the interactions of critical scale-up parameters (pH, pO2 and pCO2) on CHO batch performance and critical quality attributes

(2016) Matthias Brunner et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

High-throughput screening and selection of mammalian cells for enhanced protein production

(2016) Joseph J. Priola et al.   Biotechnology Journal

High-throughput screening and selection of mammalian cells for enhanced protein production

(2016) Joseph J. Priola et al.   Biotechnology Journal

Cell line development for biomanufacturing processes: recent advances and an outlook

(2015) Huong Le et al.   BIOTECHNOLOGY LETTERS

PCA model building with missing data: New proposals and a comparative study

(2015) A. Folch-Fortuny et al.   CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS

Big Data for Health

(2015) Javier Andreu-Perez et al.   IEEE Journal of Biomedical and Health Informatics

Recent advances in mammalian protein production

(2013) Ashok D. Bandaranayake et al.   FEBS LETTERS

Comparison of control strategies for fed-batch culture of hybridoma cells based on on-line monitoring of oxygen uptake rate, optical cell density and glucose concentration

(2013) Antoni Casablancas et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

(2012) Manuel J. T. Carrondo et al.   Biotechnology Journal

Paired-Samples Tests of Equivalence

(2012) Constance A. Mara et al.   COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION

Equivalence tests – A review

(2012) Michael Meyners   FOOD QUALITY AND PREFERENCE

The 1000 Genomes Project: data management and community access

(2012) Laura Clarke et al.   NATURE METHODS

Understanding Equivalence and Noninferiority Testing

(2010) Esteban Walker et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

(2009) Zizhuo Xing et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview

(2008) Felix Garcia-Ochoa et al.   BIOTECHNOLOGY ADVANCES

Twenty-four well plate miniature bioreactor system as a scale-down model for cell culture process development

(2008) Aaron Chen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Moving average PLS soft sensor for online product quality estimation in an industrial batch polymerization process

(2008) Pierantonio Facco et al.   JOURNAL OF PROCESS CONTROL