Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

Synthesis and SARs of dopamine derivatives as potential inhibitors of influenza virus PAN endonuclease

(2020) Yixian Liao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1

(2019) Václav Zima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influenza virus polymerase inhibitors in clinical development

(2019) Frederick G. Hayden et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Antivirals targeting the polymerase complex of influenza viruses

(2019) Edin J. Mifsud et al.   ANTIVIRAL RESEARCH

Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents

(2019) Anand S. Chintakrindi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Experimental validation and computational modeling of anti-influenza effects of quercetin-3-O-α-L-rhamnopyranoside from indigenous south African medicinal plant Rapanea melanophloeos

(2019) Parvaneh Mehrbod et al.   BMC Complementary and Alternative Medicine

Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development

(2018) Jiantao Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Sa1467 - Anticancer Effects of Quercetin on Cholangiocarcinoma

(2018) Si-Min Tang et al.   GASTROENTEROLOGY

Antioxidant and anti-inflammatory activities of quercetin and its derivatives

(2018) Marija Lesjak et al.   Journal of Functional Foods

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

(2018) Shinya Omoto et al.   Scientific Reports

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

(2018) Xi Li et al.   Frontiers in Pharmacology

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

(2018) Frederick G. Hayden et al.   NEW ENGLAND JOURNAL OF MEDICINE

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

(2018) Takeshi Noshi et al.   ANTIVIRAL RESEARCH

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors

(2018) Milan Kožíšek et al.   BIOCHEMICAL JOURNAL

Accurate DFT-D3 Calculations in a Small Basis Set

(2017) Jiří Hostaš et al.   Journal of Chemical Theory and Computation

Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives

(2017) Han Ju et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nature nominee quercetin's anti-influenza combat strategy-Demonstrations and remonstrations

(2017) Enkhtaivan Gansukh et al.   REVIEWS IN MEDICAL VIROLOGY

Antiviral activity of chlorogenic acid against influenza A (H1N1/H3N2) virus and its inhibition of neuraminidase

(2017) Yue Ding et al.   Scientific Reports

Antiviral therapies on the horizon for influenza

(2016) Lieve Naesens et al.   CURRENT OPINION IN PHARMACOLOGY

Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression

(2016) Bipin Vaidya et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cuby: An integrative framework for computational chemistry

(2016) Jan Řezáč   JOURNAL OF COMPUTATIONAL CHEMISTRY

DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening

(2016) Václav Navrátil et al.   NUCLEIC ACIDS RESEARCH

Probing the impact of quercetin-7-O-glucoside on influenza virus replication influence

(2016) Enkhtaivan Gansukh et al.   PHYTOMEDICINE

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

(2016) Min-Suk Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine

(2016) Zekun Liu et al.   Scientific Reports

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes

(2016) Mauro Carcelli et al.   Scientific Reports

Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections—A review

(2015) Asif Ahmad et al.   FOOD RESEARCH INTERNATIONAL

Discovery of Metal Ions Chelator Quercetin Derivatives with Potent Anti-HCV Activities

(2015) Dongwei Zhong et al.   MOLECULES

Studies on Transition Metal-Quercetin Complexes Using Electrospray Ionization Tandem Mass Spectrometry

(2015) Yuanzhen Liu et al.   MOLECULES

A Phase I Dose Escalation Study Demonstrates Quercetin Safety and Explores Potential for Bioflavonoid Antivirals in Patients with Chronic Hepatitis C

(2015) Nu T. Lu et al.   PHYTOTHERAPY RESEARCH

Synthesis, characterization and study of antioxidant activity of quercetin–magnesium complex

(2015) Nilanjan Ghosh et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Evaluation of a quercetin–gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging

(2015) Thenmozhi Muthurajan et al.   RSC Advances

Synthesis of 6- or 8-Bromo Flavonoids by Regioselective Mono-Bromination and Deprotection Protocol from Flavonoid Alkyl Ethers

(2015) Guojun Pan et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Biologically Active Metabolites Produced by the Basidiomycete Quambalaria cyanescens

(2015) Eva Stodůlková et al.   PLoS One

Inhibitory potency of flavonoid derivatives on influenza virus neuraminidase

(2014) Christin Rakers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

(2014) Yixi Xie et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis of chlorinated flavonoids with anti-inflammatory and pro-apoptotic activities in human neutrophils

(2014) Marisa Freitas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Effects of Flavonoids on Bone

(2014) Ailsa A. Welch et al.   Current Osteoporosis Reports

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Novel One-pot Synthesis of Polysubstituted Isocoumarins from Arynes and Trifluoroacetylated β-Diketones

(2013) Kentaro Okuma et al.   CHEMISTRY LETTERS

Recent progress and challenges in the discovery of new neuraminidase inhibitors

(2013) Supakarn Chamni et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Identification of Influenza Endonuclease Inhibitors Using a Novel Fluorescence Polarization Assay

(2012) Brandi M. Baughman et al.   ACS Chemical Biology

Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy

(2012) Ming-Ming Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Life or death: Neuroprotective and anticancer effects of quercetin

(2012) Federico Dajas   JOURNAL OF ETHNOPHARMACOLOGY

Anticancer effect and mechanism of polymer micelle-encapsulated quercetin on ovarian cancer

(2012) Xiang Gao et al.   Nanoscale

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

(2012) Rebecca M. DuBois et al.   PLoS Pathogens

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

GC (Guanine-Cytosine)-Selective DNA-Binding and Antitumor Activity of a QuercetinManganese(II) Complex

(2011) Jun Tan et al.   CHEMISTRY & BIODIVERSITY

Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications

(2011) Noboru Uchide et al.   MOLECULES

Quercetin 3-rhamnoside Exerts Antiinfluenza A Virus Activity in Mice

(2011) Hwa Jung Choi et al.   PHYTOTHERAPY RESEARCH

Antiviral activity of four types of bioflavonoid against dengue virus type-2

(2011) Keivan Zandi et al.   Virology Journal

Integration, scaling, space-group assignment and post-refinement

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Inhibition of influenza virus replication by plant-derived isoquercetin

(2010) Yunjeong Kim et al.   ANTIVIRAL RESEARCH

Flavonoids and age-related disease: Risk, benefits and critical windows

(2010) J.K. Prasain et al.   MATURITAS

In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

(2010) H.D. Gravina et al.   RESEARCH IN VETERINARY SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities

(2009) Hyung Jae Jeong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication

(2009) Hwa Jung Choi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus

(2008) Hwa-Jung Choi et al.   ANTIVIRAL RESEARCH

Quercetin in a lotus leaves extract may be responsible for antibacterial activity

(2008) Mingyu Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Structure–activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities

(2008) Ai-Lin Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enhanced anti-influenza A virus activity of (−)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: Effect of alkyl chain length

(2008) Shuichi Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-Influenza Virus Activities of Flavonoids from the Medicinal PlantElsholtzia rugulosa

(2008) Ai-Lin Liu et al.   PLANTA MEDICA