TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

(2020) Cefan Zhou et al.   Molecular Cancer

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ

(2019) Xiaobo Zhang et al.   ONCOLOGY REPORTS

SLC3A2/CD98hc, autophagy and tumor radioresistance: a link confirmed

(2019) David Digomann et al.   Autophagy

Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction

(2019) Cefan Zhou et al.   Cell Communication and Signaling

STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I

(2019) Cefan Zhou et al.   Autophagy

Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers

(2018) Mireia Nàger et al.   Autophagy

Suppression of microRNA-454 impedes the proliferation and invasion of prostate cancer cells by promoting N-myc downstream-regulated gene 2 and inhibiting WNT/β-catenin signaling

(2018) Qiang Fu et al.   BIOMEDICINE & PHARMACOTHERAPY

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

(2018) Luke J. Fulcher et al.   Science Signaling

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer

(2018) Hadas Gibori et al.   Nature Communications

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

(2018) Luke J. Fulcher et al.   Science Signaling

LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via modulating miR-454-3p/Stat3

(2018) Xia Zhao et al.   CANCER SCIENCE

Genome-scale analysis to identify prognostic microRNA biomarkers in patients with early stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy

(2018) Xiwen Liao et al.   Cancer Management and Research

Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles

(2018) Chan-Hyeong Lee et al.   BMC CANCER

Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells

(2018) Marion Orsini et al.   CELL DEATH AND DIFFERENTIATION

Tetraspanin 1 promotes epithelial-to-mesenchymal transition and metastasis of cholangiocarcinoma via PI3K/AKT signaling

(2018) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

FSIP1 regulates autophagy in breast cancer

(2018) Caigang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase 3 is associated with gastric cancer cell growth via the miR-454-mediated targeting of CHD5

(2017) Guangru Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Identification of glycerol-3-phosphate dehydrogenase 1 as a tumour suppressor in human breast cancer

(2017) Cefan Zhou et al.   Oncotarget

FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer

(2017) S Chen et al.   Oncogenesis

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

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(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Alleviation of Lipopolysaccharides-Induced Acute Lung Injury by MiR-454

(2016) Zhengang Tao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering

(2016) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Prognostic significance of PLIN1 expression in human breast cancer

(2016) Cefan Zhou et al.   Oncotarget

MicroRNA-454 regulates stromal cell derived factor-1 in the control of the growth of pancreatic ductal adenocarcinoma

(2016) Yue Fan et al.   Scientific Reports

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment

(2016) Cefan Zhou et al.   Scientific Reports

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

(2016) Daniel Zeitouni et al.   Cancers

Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism

(2015) Rushika M. Perera et al.   NATURE

MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels

(2015) Leigh Goedeke et al.   NATURE MEDICINE

miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma

(2015) Lei Yu et al.   Oncotarget

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

(2013) Katy J Petherick et al.   EMBO JOURNAL

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer

(2013) SHI-YONG ZHOU et al.   Oncology Letters

TCF/LEFs and Wnt Signaling in the Nucleus

(2012) K. M. Cadigan et al.   Cold Spring Harbor Perspectives in Biology

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

MicroRNA-Driven Developmental Remodeling in the Brain Distinguishes Humans from Other Primates

(2011) Mehmet Somel et al.   PLOS BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Assaying autophagic activity in transgenic GFP-Lc3 and GFP-Gabarap zebrafish embryos

(2009) Congcong He et al.   Autophagy

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Glycosylation of Tetraspanin Tspan-1 at Four Distinct Sites Promotes Its Transition Through the Endoplasmic Reticulum

(2009) Claus-Jurgen Scholz et al.   PROTEIN AND PEPTIDE LETTERS

Tspan-1 is a tetraspanin preferentially expressed by mucinous and endometrioid subtypes of human ovarian carcinomas

(2008) Claus-Jürgen Scholz et al.   CANCER LETTERS

Stabilization of β-Catenin Induces Pancreas Tumor Formation

(2008) Patrick W. Heiser et al.   GASTROENTEROLOGY