Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis

Idiopathic pulmonary fibrosis is associated with tight junction protein alterations

(2020) Jinjing Zou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state

(2019) Nunzia Caporarello et al.   THORAX

A fragment of SPARC reflecting increased collagen affinity shows pathological relevance in lung cancer – implications of a new collagen chaperone function of SPARC

(2018) S.N. Kehlet et al.   CANCER BIOLOGY & THERAPY

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis

(2018) Liudi Yao et al.   CELL DEATH AND DIFFERENTIATION

An Evaluation of SPARC Protein as a Serum Biomarker of Chronic Rhinosinusitis

(2018) Marc-Henri Asmar et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease

(2016) Sharon L I Wong et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals

(2016) Chun-Chun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Systematic Review of the Role of Dysfunctional Wound Healing in the Pathogenesis and Treatment of Idiopathic Pulmonary Fibrosis

(2016) Alan Betensley et al.   Journal of Clinical Medicine

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Wound repair: role of immune–epithelial interactions

(2015) G Leoni et al.   Mucosal Immunology

Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis

(2015) Shigehisa Yanagi et al.   Biomed Research International

Paracrine communication maximizes cellular response fidelity in wound signaling

(2015) L Naomi Handly et al.   eLife

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

(2014) Christine Jean et al.   JOURNAL OF CELL BIOLOGY

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

(2014) Matthew W. Parker et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the extracellular matrix: Matricellular proteins regulate cell–extracellular matrix communication within distinct niches of the intervertebral disc

(2014) Jake Bedore et al.   MATRIX BIOLOGY

The importance of both fibroblasts and keratinocytes in a bilayered living cellular construct used in wound healing

(2014) Abigail M. Wojtowicz et al.   WOUND REPAIR AND REGENERATION

A Novel Molecular Pathway for Snail-Dependent, SPARC-Mediated Invasion in Non-Small Cell Lung Cancer Pathogenesis

(2013) J. L. Grant et al.   Cancer Prevention Research

Exogenous SPARC Suppresses Proliferation and Migration of Prostate Cancer by Interacting With Integrin β1

(2013) Minkyoung Shin et al.   PROSTATE

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An integrin–ILK–microtubule network orients cell polarity and lumen formation in glandular epithelium

(2012) Nasreen Akhtar et al.   NATURE CELL BIOLOGY

SPARC Oppositely Regulates Inflammation and Fibrosis in Bleomycin-Induced Lung Damage

(2011) Sabina Sangaletti et al.   AMERICAN JOURNAL OF PATHOLOGY

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

(2011) Ganesh Raghu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

(2011) Lee B. Rivera et al.   JOURNAL OF CELL BIOLOGY

Diminished Prostaglandin E2Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

(2010) Toby M. Maher et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Reaction-Diffusion Model of the Cadherin-Catenin System: A Possible Mechanism for Contact Inhibition and Implications for Tumorigenesis

(2010) Markus Basan et al.   BIOPHYSICAL JOURNAL

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

(2010) Wenteh Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTEN augments SPARC suppression of proliferation and inhibits SPARC-induced migration by suppressing SHC-RAF-ERK and AKT signaling

(2010) Stacey L. Thomas et al.   NEURO-ONCOLOGY

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

(2010) Jiu-Cun Wang et al.   ARTHRITIS RESEARCH & THERAPY

Zonula Occludens-1 and -2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

(2009) Alan S. Fanning et al.   Annals of the New York Academy of Sciences

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS