Article
Plant Sciences
Yuezhi Wang, Meisong Dai, Xinyi Wu, Shujun Zhang, Zebin Shi, Danying Cai, Lixiang Miao
Summary: This study identified a key gene PyPPCD1.1 in cork formation of pear fruit skin, which triggers programmed cell death and regulates periderm development.
HORTICULTURE RESEARCH
(2022)
Review
Cell Biology
Yujie Gan, Huanhuan Sha, Renrui Zou, Miao Xu, Yuan Zhang, Jifeng Feng, Jianzhong Wu
Summary: This review provides an update on methodological advances in the study of ADP-ribosylation and discusses the function and therapeutic potential of mono-ADP-ribosylation in cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Wen Chen, Anjelika Gasilina, Mukesh P. Yadav, Paul A. Randazzo
Summary: ADP-ribosylation factors (Arfs) are a family of regulatory GTP binding proteins that primarily regulate membrane trafficking and cytoskeleton remodeling. In addition, Arfs have been found to play a role in signaling and integrating multiple signaling pathways to influence specific cell behaviors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Andrea Hlousek-Kasun, Petra Mikolcevic, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matkovic, Branimir Bertosa, Ivan Ahel, Andreja Mikoc
Summary: ADP-ribosylation is an important covalent modification that plays critical roles in various biological processes. The toxin/antitoxin pair DarT/DarG has been discovered, where DarT modifies DNA and DarG reverses this modification. The homologue SCO6735 is highly conserved and associated with antibiotic production in bacteria, and it can also reverse the ADP-ribosylation catalyzed by DarT.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Oncology
Sachiko Yamashita, Masakazu Tanaka, Chieri Ida, Kenichi Kouyama, Setsu Nakae, Taisuke Matsuki, Masataka Tsuda, Tsuyoshi Shirai, Kazuo Kamemura, Yoshisuke Nishi, Joel Moss, Masanao Miwa
Summary: This study investigates the regulation of cell proliferation by polyADP-ribosylation, revealing significantly higher levels of PAR in S phase compared to G1 phase, and a short half-life of PAR. Inhibition of PARP delays the cell cycle and decreases cell proliferation.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Marisa Nacke, Emma Sandilands, Konstantina Nikolatou, Alvaro Roman-Fernandez, Susan Mason, Rachana Patel, Sergio Lilla, Tamas Yelland, Laura C. A. Galbraith, Eva C. Freckmann, Lynn McGarry, Jennifer P. Morton, Emma Shanks, Hing Y. Leung, Elke Markert, Shehab Ismail, Sara Zanivan, Karen Blyth, David M. Bryant
Summary: The study reveals that different isoforms of the ARF GTPase exchange factor IQSEC1 direct phosphoinositide metabolism to promote invasive responses in cells rather than growth responses.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Multidisciplinary
Chaochao Luo, Wanwan Peng, Jia Kang, Caiming Chen, Jiajia Peng, Yue Wang, Qian Tang, Hailong Xie, Yazi Li, Xinghua Pan
Summary: This study demonstrates that glutamine (Gln) positively regulates cell growth and casein synthesis in bovine mammary epithelial cells (BMECs) through the CYTHs/ARFGAP1-Arf1-mTORC1 pathway, providing new insights into the regulation of the mTOR pathway by amino acids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Preksha Bhagchandani, Charles A. Chang, Weichen Zhao, Luiza Ghila, Pedro L. Herrera, Simona Chera, Seung K. Kim
Summary: This study introduces a new model of experimental diabetes, the B6 RIP-DTR mouse, which can efficiently induce diabetes and be used for islet transplantation. The model has reliable diabetes induction and the rejection response of transplanted islets can be monitored through blood glucose and histology. Different immune cells can be distinguished using flow cytometry in this model.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Mario Leutert, Yinghui Duan, Riekje Winzer, Stephan Menzel, Eva Tolosa, Tim Magnus, Michael O. Hottiger, Friedrich Koch-Nolte, Bjoern Rissiek
Summary: This study identified ADP-ribosylated peptides and their targets on mouse T cell surface, including known proteins like CD8a, CD25, and CD73. The results demonstrated that ADP-ribosylation reduces the enzymatic activity of CD73 in generating adenosine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Stephanie C. Luthi, Anna Howald, Kathrin Nowak, Robert Graage, Giody Bartolomei, Christine Neupert, Xaver Sidler, Deena Leslie Pedrioli, Michael O. Hottiger
Summary: Plasma phosphodiesterases and/or ADP-ribosylhydrolases were found to rapidly remove post-translational modifications in vitro ADP-ribosylated proteins. Mass spectrometry identified a total of 60 ADP-ribosylated proteins, with 17 of them being ADP-ribosylated plasma proteins. This new protocol marks an important advancement in the field of ADP-ribosylation and provides insights into ADP-ribosylomes in blood and plasma under different conditions.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemical Research Methods
Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang
Summary: In this study, the protein interaction network of the human PLD family of enzymes and PA was defined using a proteomic approach. The study identified PJA2 as a novel E3 ubiquitin ligase for PLD1 and revealed the positive regulation of sphingosine kinase 1 by PA. The findings not only provide a rich resource for further characterization of the human PLD-PA lipid signaling, but also connect this important metabolic pathway with numerous biological processes.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Review
Food Science & Technology
Kohei Ogura, Kinnosuke Yahiro, Joel Moss
Summary: Pathogenic microorganisms produce various virulence factors, such as enzymes and cytotoxins, which play a role in the development of infectious diseases. Cholix, a novel eukaryotic elongation factor 2 adenosine-diphosphate ribosyltransferase produced by Vibrio cholerae, has been identified but its specific function in cholera infections remains unclear.
Review
Pharmacology & Pharmacy
Marie Eggers, Felix Ruehl, Friedrich Haag, Friedrich Koch-Nolte
Summary: Nanobodies, the single variable immunoglobulin domains of heavy chain antibodies naturally occurring in camelids, have a hydrophilic surface area which makes them highly soluble, robust in harsh environments, and exceptionally easy to format into bispecific reagents. The unique properties of nanobodies have been utilized in modulating purinergic signaling, with examples targeting P2X7, CD38, and ARTC2.2.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Virology
Catherine M. Kerr, Srivatsan Parthasarathy, Nancy Schwarting, Joseph J. O'Connor, Jessica J. Pfannenstiel, Emily Giri, Sunil More, Robin C. Orozco, Anthony R. Fehr
Summary: PARP12 is an important mediator of the antiviral response to coronaviruses, but additional PARPs or innate immune factors contribute to virus attenuation in mice. PARP12 knockout increases Mac1 mutant virus replication and liver pathology in mice.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Tomoko Kubori, Junyup Lee, Hyunmin Kim, Kohei Yamazaki, Masanari Nishikawa, Tomoe Kitao, Byung-Ha Oh, Hiroki Nagai
Summary: The intracellular bacterial pathogen Legionella pneumophila utilizes a pair of effector proteins, Lpg0080 and Lpg0081, to coordinately manipulate mitochondrial activity in host cells by enzymatically modifying ADP/ATP translocases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Kuan-Min Fang, Jun-Jen Liu, Chun-Chun Li, Chih-Chi Cheng, Yun-Ti Hsieh, Kit Man Chai, Yu-An Lien, Shun-Fen Tzeng
JOURNAL OF NEURO-ONCOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Tzu-Yu Huang, Yi-Hsin Lin, Heng-Ai Chang, Tzu-Ying Yeh, Ya-Han Chang, Yi-Fan Chen, Ying-Chi Chen, Chun-Chun Li, Wen-Tai Chiu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Multidisciplinary Sciences
Chun-Chun Li, Tsung-Sheng Wu, Chun-Fang Huang, Li-Ting Jang, Yu-Tsan Liu, Shu-Ting You, Gunn-Guang Liou, Fang-Jen S. Lee
Article
Multidisciplinary Sciences
Ermanno Puxeddu, Marina Uhart, Chun-Chun Li, Faiyaz Ahmad, Gustavo Pacheco-Rodriguez, Vincent C. Manganiello, Joel Moss, Martha Vaughan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Chun-Chun Li, Jean-Cheng Kuo, Clare M. Waterman, Ryoiti Kiyama, Joel Moss, Martha Vaughan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Multidisciplinary Sciences
Xiaoyan Shen, Chun-Chun Li, Angel M. Aponte, Rong-Fong Shen, Eric M. Billings, Joel Moss, Martha Vaughan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2012)
Article
Multidisciplinary Sciences
Kang Le, Chun-Chun Li, Guan Ye, Joel Moss, Martha Vaughan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Biochemistry & Molecular Biology
Fu-I Lu, Yi-Ting Wang, Yi-Shan Wang, Chang-Yi Wu, Chun-Chun Li
Article
Cell Biology
Shin-Jin Lin, Chun-Fang Huang, Tsung-Sheng Wu, Chun-Chun Li, Fang-Jen S. Lee
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Biology
Boimpoundi Eunice Flavie Ouali, Tzu-Yu Liu, Chun-Yen Lu, Pei-Yuan Cheng, Chao-Li Huang, Chun-Chun Li, Yu-Chung Chiang, Hao-Ven Wang
BMC RESEARCH NOTES
(2020)
Article
Biochemistry & Molecular Biology
Shu-Jing Chang, Ying-Chi Chen, Chi-Hsun Yang, Soon-Cen Huang, Ho-Kai Huang, Chun-Chun Li, Hans I-Chen Harn, Wen-Tai Chiu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Cell Biology
Chun-Chun Li, Tsai-Chen Chiang, Tsung-Sheng Wu, Gustavo Pacheco-Rodriguez, Joel Moss, Fang-Jen S. Lee
MOLECULAR BIOLOGY OF THE CELL
(2007)
Article
Cell Biology
CY Lin, CC Li, PH Huang, FJS Lee
JOURNAL OF CELL SCIENCE
(2002)