The SPARC protein: an overview of its role in lung cancer and pulmonary fibrosis and its potential role in chronic airways disease

Matricellular proteins in drug delivery: Therapeutic targets, active agents, and therapeutic localization

(2016) Andrew J. Sawyer et al.   ADVANCED DRUG DELIVERY REVIEWS

SPARC-Independent Delivery of Nab-Paclitaxel without Depleting Tumor Stroma in Patient-Derived Pancreatic Cancer Xenografts

(2016) H. Kim et al.   MOLECULAR CANCER THERAPEUTICS

High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells

(2016) Yu-Ching Chen et al.   Scientific Reports

Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanism

(2015) Bryan Hoang et al.   BIOMATERIALS

Loss ofSparcinp53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival

(2015) Stacey L. Thomas et al.   BRAIN PATHOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fstl1 Promotes Asthmatic Airway Remodeling by Inducing Oncostatin M

(2015) Marina Miller et al.   JOURNAL OF IMMUNOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

SPARC Ameliorates Ovarian Cancer-Associated Inflammation

(2015) Neveen A. Said et al.   NEOPLASIA

Epithelium-dependent profibrotic milieu in the pathogenesis of idiopathic pulmonary fibrosis: current status and future directions

(2014) Xuefeng Xu et al.   Clinical Respiratory Journal

SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis

(2014) Zhen Luo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pulmonary vascular changes in asthma and COPD

(2014) Louise M. Harkness et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Transforming growth factor β and severe asthma: A perfect storm

(2014) Mazen Al-Alawi et al.   RESPIRATORY MEDICINE

SPARC Expression Correlates with Tumor Response to Albumin-Bound Paclitaxel in Head and Neck Cancer Patients

(2014) Neil Desai et al.   Translational Oncology

The epithelium in idiopathic pulmonary fibrosis: breaking the barrier

(2014) Ana Camelo et al.   Frontiers in Pharmacology

Stromal niche communalities underscore the contribution of the matricellular protein SPARC to B-cell development and lymphoid malignancies

(2014) Sabina Sangaletti et al.   OncoImmunology

A Novel Molecular Pathway for Snail-Dependent, SPARC-Mediated Invasion in Non-Small Cell Lung Cancer Pathogenesis

(2013) J. L. Grant et al.   Cancer Prevention Research

Asthma and Chronic Obstructive Pulmonary Disease

(2013) Dirkje S. Postma et al.   CLINICS IN CHEST MEDICINE

SPARC independent drug delivery and antitumour effects ofnab-paclitaxel in genetically engineered mice

(2013) Albrecht Neesse et al.   GUT

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Secreted Protein Acidic and Rich in Cysteine (SPARC) Exacerbates Colonic Inflammatory Symptoms in Dextran Sodium Sulphate-Induced Murine Colitis

(2013) Yoke-Leng Ng et al.   PLoS One

Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma

(2012) Bharathi Gorantla et al.   ANGIOGENESIS

RAGE: a new frontier in chronic airways disease

(2012) Maria B Sukkar et al.   BRITISH JOURNAL OF PHARMACOLOGY

The pathogenesis of pulmonary fibrosis: a moving target

(2012) Wim A. Wuyts et al.   EUROPEAN RESPIRATORY JOURNAL

Diverse biological functions of the SPARC family of proteins

(2012) Amy D. Bradshaw   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Losartan Slows Pancreatic Tumor Progression and Extends Survival of SPARC-Null Mice by Abrogating Aberrant TGFβ Activation

(2012) Shanna A. Arnold et al.   PLoS One

Secreted Protein Acidic and Rich in Cysteine (SPARC) Suppresses Angiogenesis by Down-Regulating the Expression of VEGF and MMP-7 in Gastric Cancer

(2012) Jun-Ling Zhang et al.   PLoS One

SPARC Oppositely Regulates Inflammation and Fibrosis in Bleomycin-Induced Lung Damage

(2011) Sabina Sangaletti et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis

(2011) Manabu Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The regulatory function of SPARC in vascular biology

(2011) Lee B. Rivera et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lung Cancer: Epidemiology, Etiology, and Prevention

(2011) Charles S. Dela Cruz et al.   CLINICS IN CHEST MEDICINE

The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses

(2011) Silvia Piconese et al.   JOURNAL OF AUTOIMMUNITY

Improved Response to nab-Paclitaxel Compared with Cremophor-Solubilized Paclitaxel is Independent of Secreted Protein Acidic and Rich in Cysteine Expression in Non-Small Cell Lung Cancer

(2011) Huanjie Shao et al.   Journal of Thoracic Oncology

A Peptide of SPARC Interferes with the Interaction between Caspase8 and Bcl2 to Resensitize Chemoresistant Tumors and Enhance Their Regression In Vivo

(2011) Mahbuba Rahman et al.   PLoS One

Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights

(2011) Ian M. Adcock et al.   RESPIRATION

Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis

(2010) Claudia Chiodoni et al.   CANCER AND METASTASIS REVIEWS

KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression

(2010) Yanbin Zhou et al.   CANCER BIOLOGY & THERAPY

Persistent Activation of the Fyn/ERK Kinase Signaling Axis Mediates Imatinib Resistance in Chronic Myelogenous Leukemia Cells through Upregulation of Intracellular SPARC

(2010) N. Fenouille et al.   CANCER RESEARCH

SPARC Suppresses Apoptosis of Idiopathic Pulmonary Fibrosis Fibroblasts through Constitutive Activation of β-Catenin

(2010) Wenteh Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors

(2010) Alexandre Chlenski et al.   Molecular Cancer

Reactive Oxygen Species Are Required for Maintenance and Differentiation of Primary Lung Fibroblasts in Idiopathic Pulmonary Fibrosis

(2010) Marialuisa Bocchino et al.   PLoS One

Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing

(2009) Amy D. Bradshaw et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Factors associated with local and distant recurrence and survival in patients with resected nonsmall cell lung cancer

(2009) John M. Varlotto et al.   CANCER

Pressure Overload–Induced Alterations in Fibrillar Collagen Content and Myocardial Diastolic Function

(2009) Amy D. Bradshaw et al.   CIRCULATION

Snail Promotes CXCR2 Ligand-Dependent Tumor Progression in Non-Small Cell Lung Carcinoma

(2009) J. Yanagawa et al.   CLINICAL CANCER RESEARCH

Bronchial vascular remodelling in patients with COPD and its relationship with inhaled steroid treatment

(2009) A Zanini et al.   THORAX

Macrophage-Derived SPARC Bridges Tumor Cell-Extracellular Matrix Interactions toward Metastasis

(2008) Sabina Sangaletti et al.   CANCER RESEARCH

Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti–Salmonella typhimuriumimmunity

(2008) Gianluca Rotta et al.   JOURNAL OF EXPERIMENTAL MEDICINE