Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation

Fbxo45 binds SPRY motifs in the extracellular domain of N-cadherin and regulates neuron migration during brain development

(2020) Youn Na et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular mechanisms of cell polarity in a range of model systems and in migrating neurons

(2020) Yves Jossin   MOLECULAR AND CELLULAR NEUROSCIENCE

Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice

(2020) Eisuke Okugawa et al.   Scientific Reports

Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches

(2020) Branden R Nelson et al.   eLife

Differential Action of Reelin on Oligomerization of ApoER2 and VLDL Receptor in HEK293 Cells Assessed by Time-Resolved Anisotropy and Fluorescence Lifetime Imaging Microscopy

(2019) Paula Dlugosz et al.   Frontiers in Molecular Neuroscience

Targeting the Synapse in Alzheimer’s Disease

(2019) Johanna Jackson et al.   Frontiers in Neuroscience

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum

(2019) Yuko Yamakage et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration

(2019) Elif Kon et al.   eLife

Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy

(2019) Daniela Rossi et al.   PROGRESS IN NEUROBIOLOGY

Developmental abnormality contributes to cortex-dependent motor impairments and higher intracortical current requirement in the reeler homozygous mutants

(2018) Mariko Nishibe et al.   Brain Structure & Function

Moving into shape: cell migration during the development and histogenesis of the cerebellum

(2018) Karl Schilling   HISTOCHEMISTRY AND CELL BIOLOGY

Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder

(2018) Sandra M. Sánchez-Sánchez et al.   HUMAN MUTATION

Reelin Depletion is an Early Phenomenon of Alzheimer's Pathology

(2018) Arne Herring et al.   JOURNAL OF ALZHEIMERS DISEASE

Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia

(2018) Akira Sobue et al.   Scientific Reports

The Reelin Receptors Apolipoprotein E receptor 2 (ApoER2) and VLDL Receptor

(2018) Paula Dlugosz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic regulation of RELN and GAD1 in the frontal cortex (FC) of autism spectrum disorder (ASD) subjects

(2017) Adrian Zhubi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Trajectory analysis unveils Reelin's role in the directed migration of granule cells in the dentate gyrus

(2017) Shaobo Wang et al.   JOURNAL OF NEUROSCIENCE

Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin

(2017) Himari Ogino et al.   JOURNAL OF NEUROSCIENCE

Reelin (RELN) DNA methylation in the peripheral blood of schizophrenia

(2017) Rahim Mohd Nabil Fikri et al.   JOURNAL OF PSYCHIATRIC RESEARCH

CLASP2 Links Reelin to the Cytoskeleton during Neocortical Development

(2017) Gregory M. Dillon et al.   NEURON

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus

(2017) Burkhard Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex

(2017) Elif Kon et al.   Frontiers in Cellular Neuroscience

GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse

(2017) Sylvia Pfennig et al.   Cell Reports

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

(2017) Jie Gao et al.   eLife

Optogenetic control of the Dab1 signaling pathway

(2017) Liang Wang et al.   Scientific Reports

ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex

(2016) Yuki Hirota et al.   CEREBRAL CORTEX

Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells

(2016) Carles Bosch et al.   CEREBRAL CORTEX

Reelin and cofilin cooperate during the migration of cortical neurons: a quantitative morphological analysis

(2016) Xuejun Chai et al.   DEVELOPMENT

Nonneuronal roles for the reelin signaling pathway

(2016) Elvira Khialeeva et al.   DEVELOPMENTAL DYNAMICS

Very mild features of dysequilibrium syndrome associated with a novel VLDLR missense mutation

(2016) Alessia Micalizzi et al.   NEUROGENETICS

The C-terminal region of Reelin is necessary for proper positioning of a subset of Purkinje cells in the postnatal cerebellum

(2016) Kota Nakamura et al.   NEUROSCIENCE

RELN Mutations in Autism Spectrum Disorder

(2016) Dawn B. Lammert et al.   Frontiers in Cellular Neuroscience

Seizure-Induced Motility of Differentiated Dentate Granule Cells Is Prevented by the Central Reelin Fragment

(2016) Catarina Orcinha et al.   Frontiers in Cellular Neuroscience

Heterozygous Reelin Mutations Cause Autosomal-Dominant Lateral Temporal Epilepsy

(2015) Emanuela Dazzo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

AKT-independent Reelin signaling requires interactions of heterotrimeric Go and Src

(2015) Sung-Kuk Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner

(2015) Amanda Marie DiBattista et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

(2015) Isobel D. Lawrenson et al.   CEREBRAL CORTEX

Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage

(2015) Yoshitaka Sato et al.   JOURNAL OF BIOCHEMISTRY

Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation

(2015) R. S. O'Dell et al.   JOURNAL OF NEUROSCIENCE

Importance of Reelin C-Terminal Region in the Development and Maintenance of the Postnatal Cerebral Cortex and Its Regulation by Specific Proteolysis

(2015) T. Kohno et al.   JOURNAL OF NEUROSCIENCE

LRP8-Reelin-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation

(2015) Francesca Telese et al.   NEURON

Extracellular matrix protein reelin regulate dendritic spine density through CaMKIIβ

(2015) Mihyun Kim et al.   NEUROSCIENCE LETTERS

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling

(2015) Emanuele Brai et al.   Frontiers in Cellular Neuroscience

Reelin protects against amyloid β toxicity in vivo

(2015) Courtney Lane-Donovan et al.   Science Signaling

Reelin Signaling Specifies the Molecular Identity of the Pyramidal Neuron Distal Dendritic Compartment

(2014) Justine V. Kupferman et al.   CELL

Reelin Induces Branching of Neurons and Radial Glial Cells during Corticogenesis

(2014) Xuejun Chai et al.   CEREBRAL CORTEX

Transcriptomics Study of Neurodegenerative Disease: Emphasis on Synaptic Dysfunction Mechanism in Alzheimer’s Disease

(2014) Sajjad Karim et al.   CNS & Neurological Disorders-Drug Targets

Reelin Induces Erk1/2 Signaling in Cortical Neurons Through a Non-canonical Pathway

(2014) Gum Hwa Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage within Reelin Repeat 3 Regulates the Duration and Range of the Signaling Activity of Reelin Protein

(2014) Mari Koie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex

(2014) Yuki Hirota et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Hippocampal Pyramidal Neurons Switch from a Multipolar Migration Mode to a Novel "Climbing" Migration Mode during Development

(2014) A. Kitazawa et al.   JOURNAL OF NEUROSCIENCE

Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation

(2014) J.H. Trotter et al.   NEUROSCIENCE

Neuronal subtype specification in establishing mammalian neocortical circuits

(2014) Takuma Kumamoto et al.   NEUROSCIENCE RESEARCH

Extracortical origin of some murine subplate cell populations

(2014) M. Pedraza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

(2014) Thomas E. Chater et al.   Frontiers in Cellular Neuroscience

Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease

(2014) Lluís Pujadas et al.   Nature Communications

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

(2014) Meghan Morgan-Smith et al.   eLife

Autism genetics

(2013) Antonio M. Persico et al.   BEHAVIOURAL BRAIN RESEARCH

Cerebellar granule cells are generated postnatally in humans

(2013) Maren C. Kiessling et al.   Brain Structure & Function

Morphology, input–output relations and synaptic connectivity of Cajal–Retzius cells in layer 1 of the developing neocortex of CXCR4-EGFP mice

(2013) Max Anstötz et al.   Brain Structure & Function

Rbx2 Regulates Neuronal Migration through Different Cullin 5-RING Ligase Adaptors

(2013) Sergi Simó et al.   DEVELOPMENTAL CELL

Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons

(2013) Maurice Meseke et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TIMP-1 inhibits the proteolytic processing of Reelin in experimental epilepsy

(2013) Stefanie Tinnes et al.   FASEB JOURNAL

Reduced Reelin Expression Accelerates Amyloid-  Plaque Formation and Tau Pathology in Transgenic Alzheimer's Disease Mice

(2013) S. Kocherhans et al.   JOURNAL OF NEUROSCIENCE

Dab1 Is Required for Synaptic Plasticity and Associative Learning

(2013) J. Trotter et al.   JOURNAL OF NEUROSCIENCE

Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway

(2013) J Iafrati et al.   MOLECULAR PSYCHIATRY

Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition–like mechanism

(2013) Yasuhiro Itoh et al.   NATURE NEUROSCIENCE

Cajal-Retzius Cells Instruct Neuronal Migration by Coincidence Signaling between Secreted and Contact-Dependent Guidance Cues

(2013) Cristina Gil-Sanz et al.   NEURON

Reelin Mobilizes a VAMP7-Dependent Synaptic Vesicle Pool and Selectively Augments Spontaneous Neurotransmission

(2013) Manjot Bal et al.   NEURON

Hippocampal development – Old and new findings

(2013) R. Khalaf-Nazzal et al.   NEUROSCIENCE

A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner

(2012) Arisa Hisanaga et al.   FEBS LETTERS

Cell-Autonomous Inactivation of the Reelin Pathway Impairs Adult Neurogenesis in the Hippocampus

(2012) C. M. Teixeira et al.   JOURNAL OF NEUROSCIENCE

Microtubule Plus-End Tracking Protein CLASP2 Regulates Neuronal Polarity and Synaptic Function

(2012) U. Beffert et al.   JOURNAL OF NEUROSCIENCE

Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone

(2012) Ryan S O’Dell et al.   Neural Development

Reelin Controls Neuronal Positioning by Promoting Cell-Matrix Adhesion via Inside-Out Activation of Integrin α5β1

(2012) Katsutoshi Sekine et al.   NEURON

Foxp-Mediated Suppression of N-Cadherin Regulates Neuroepithelial Character and Progenitor Maintenance in the CNS

(2012) David L. Rousso et al.   NEURON

Regulated Proteolytic Processing of Reelin through Interplay of Tissue Plasminogen Activator (tPA), ADAMTS-4, ADAMTS-5, and Their Modulators

(2012) Dimitrije Krstic et al.   PLoS One

Reelin Together with ApoER2 Regulates Interneuron Migration in the Olfactory Bulb

(2012) Sabine Hellwig et al.   PLoS One

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

(2012) C. Luscher et al.   Cold Spring Harbor Perspectives in Biology

Functional Importance of Covalent Homodimer of Reelin Protein Linked via Its Central Region

(2011) Norihisa Yasui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-type-specific consequences of reelin deficiency in the mouse neocortex, hippocampus, and amygdala

(2011) Maureen P. Boyle et al.   JOURNAL OF COMPARATIVE NEUROLOGY

The Outermost Region of the Developing Cortical Plate Is Crucial for Both the Switch of the Radial Migration Mode and the Dab1-Dependent "Inside-Out" Lamination in the Neocortex

(2011) K. Sekine et al.   JOURNAL OF NEUROSCIENCE

Role for Reelin in Neurotransmitter Release

(2011) S. Hellwig et al.   JOURNAL OF NEUROSCIENCE

Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density

(2011) J. T. Rogers et al.   LEARNING & MEMORY

Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex

(2011) Yves Jossin et al.   NATURE NEUROSCIENCE

Reelin Regulates Cadherin Function via Dab1/Rap1 to Control Neuronal Migration and Lamination in the Neocortex

(2011) Santos J. Franco et al.   NEURON

Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain

(2011) A. Ventruti et al.   NEUROSCIENCE

ApoE Receptor 2 Regulates Synapse and Dendritic Spine Formation

(2011) Sonya B. Dumanis et al.   PLoS One

The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity

(2011) Javier DeFelipe   Frontiers in Neuroanatomy

Reelin and Stk25 Have Opposing Roles in Neuronal Polarization and Dendritic Golgi Deployment

(2010) Tohru Matsuki et al.   CELL

Reelin Promotes Neuronal Orientation and Dendritogenesis during Preplate Splitting

(2010) Anna J. Nichols et al.   CEREBRAL CORTEX

Dispersion of the neurons expressing layer specific markers in the reeler brain

(2010) Hideyuki Dekimoto et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Epileptiform activity interferes with proteolytic processing of Reelin required for dentate granule cell positioning

(2010) Stefanie Tinnes et al.   FASEB JOURNAL

Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy

(2010) Venceslas Duveau et al.   HIPPOCAMPUS

Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation

(2010) J. Leemhuis et al.   JOURNAL OF NEUROSCIENCE

Cullin 5 Regulates Cortical Layering by Modulating the Speed and Duration of Dab1-Dependent Neuronal Migration

(2010) S. Simo et al.   JOURNAL OF NEUROSCIENCE

Reelin Regulates Postnatal Neurogenesis and Enhances Spine Hypertrophy and Long-Term Potentiation

(2010) L. Pujadas et al.   JOURNAL OF NEUROSCIENCE

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum

(2010) Takaki Miyata et al.   Neural Development

Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study

(2010) Patricia L. Kramer et al.   NEUROBIOLOGY OF AGING

Nova2 Regulates Neuronal Migration through an RNA Switch in Disabled-1 Signaling

(2010) Masato Yano et al.   NEURON

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Specific Recognition of Reelin by Its Receptors

(2010) Norihisa Yasui et al.   STRUCTURE

Mechanism and significance of specific proteolytic cleavage of Reelin

(2009) Shiori Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The cytoplasmic adaptor protein X11α and extracellular matrix protein Reelin regulate ApoE receptor 2 trafficking and cell movement

(2009) S. Sakura Minami et al.   FASEB JOURNAL

Differential Functions of ApoER2 and Very Low Density Lipoprotein Receptor in Reelin Signaling Depend on Differential Sorting of the Receptors

(2009) Sarah Duit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in VLDLR as a Cause for Autosomal Recessive Cerebellar Ataxia With Mental Retardation (Dysequilibrium Syndrome)

(2009) Kym M. Boycott et al.   JOURNAL OF CHILD NEUROLOGY

Reelin and Notch1 Cooperate in the Development of the Dentate Gyrus

(2009) M. Sibbe et al.   JOURNAL OF NEUROSCIENCE

Reelin Stabilizes the Actin Cytoskeleton of Neuronal Processes by Inducing n-Cofilin Phosphorylation at Serine3

(2009) X. Chai et al.   JOURNAL OF NEUROSCIENCE

Downregulation of Functional Reelin Receptors in Projection Neurons Implies That Primary Reelin Action Occurs atEarly/Premigratory Stages

(2009) T. Uchida et al.   JOURNAL OF NEUROSCIENCE

β-amyloid controls altered Reelin expression and processing in Alzheimer's disease

(2009) Arancha Botella-López et al.   NEUROBIOLOGY OF DISEASE

Reelin signaling antagonizes  -amyloid at the synapse

(2009) M. S. Durakoglugil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects

(2009) Xavier H. Jaglin et al.   TRENDS IN GENETICS

Cytokinesis of neuroepithelial cells can divide their basal process before anaphase

(2008) Yoichi Kosodo et al.   EMBO JOURNAL

Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration

(2008) Sophia M Blake et al.   EMBO JOURNAL

Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis

(2008) T. Matsuki et al.   JOURNAL OF CELL SCIENCE

The Reelin Signaling Pathway Promotes Dendritic Spine Development in Hippocampal Neurons

(2008) S. Niu et al.   JOURNAL OF NEUROSCIENCE

Crk and Crk-Like Play Essential Overlapping Roles Downstream of Disabled-1 in the Reelin Pathway

(2008) T.-J. Park et al.   JOURNAL OF NEUROSCIENCE

Dual Functions of Dab1 during Brain Development

(2008) L. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction between Reelin and Notch Signaling Regulates Neuronal Migration in the Cerebral Cortex

(2008) Kazue Hashimoto-Torii et al.   NEURON

A mechanism for inside-out lamination in the neocortex

(2008) Jonathan A. Cooper   TRENDS IN NEUROSCIENCES

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia

(2007) Nicole Helbecque et al.   NEUROBIOLOGY OF AGING

Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons

(2006) C. Hoareau et al.   NEUROBIOLOGY OF AGING