Garp as a therapeutic target for modulation of T regulatory cell function

The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance

(2016) Justin P. Edwards et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting immunosuppression by Tregs with monoclonal antibodies against GARP

(2016) Stéphanie Liénart et al.   OncoImmunology

How Soluble GARP Enhances TGFβ Activation

(2016) Sven Fridrich et al.   PLoS One

Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

(2015) John J. Worthington et al.   IMMUNITY

Activated glycoprotein A repetitions predominant (GARP)–expressing regulatory T cells inhibit allergen-induced intestinal inflammation in humanized mice

(2015) Melanie Eschborn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells

(2015) Caroline Huygens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GP96 is a GARP chaperone and controls regulatory T cell functions

(2015) Yongliang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms

(2015) Daniel Bedinger et al.   mAbs

Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo

(2015) Julia Cuende et al.   Science Translational Medicine

Release of Active TGF-β1 from the Latent TGF-β1/GARP Complex on T Regulatory Cells Is Mediated by Integrin β8

(2014) Justin P. Edwards et al.   JOURNAL OF IMMUNOLOGY

CD4+ T Cells Expressing Latency-Associated Peptide and Foxp3 Are an Activated Subgroup of Regulatory T Cells Enriched in Patients with Colorectal Cancer

(2014) Jayashri Mahalingam et al.   PLoS One

Selective Targeting of TGF-  Activation to Treat Fibroinflammatory Airway Disease

(2014) S. Minagawa et al.   Science Translational Medicine

Mesenchymal Stromal Cells Express GARP/LRRC32 on Their Surface: Effects on Their Biology and Immunomodulatory Capacity

(2014) Ana Belén Carrillo-Galvez et al.   STEM CELLS

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4+ T cells

(2013) S. A. Hahn et al.   BLOOD

Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality

(2013) S. Kalathil et al.   CANCER RESEARCH

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GARP-TGF-  Complexes Negatively Regulate Regulatory T Cell Development and Maintenance of Peripheral CD4+ T Cells In Vivo

(2013) A. X. Zhou et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Expression of GARP/Latent TGF- 1 Complexes on Mouse T Cells and Their Role in Regulatory T Cell and Th17 Differentiation

(2013) J. P. Edwards et al.   JOURNAL OF IMMUNOLOGY

miR-142-3p Is Involved in CD25+ CD4 T Cell Proliferation by Targeting the Expression of Glycoprotein A Repetitions Predominant

(2013) Q. Zhou et al.   JOURNAL OF IMMUNOLOGY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

GARP Is Regulated by miRNAs and Controls Latent TGF-β1 Production by Human Regulatory T Cells

(2013) Emilie Gauthy et al.   PLoS One

GARP regulates the bioavailability and activation of TGFβ

(2012) Rui Wang et al.   MOLECULAR BIOLOGY OF THE CELL

TGF-β in transplantation tolerance

(2011) Frederico S Regateiro et al.   CURRENT OPINION IN IMMUNOLOGY

Autocrine Transforming Growth Factor-β1 Promotes In Vivo Th17 Cell Differentiation

(2011) Ilona Gutcher et al.   IMMUNITY

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice

(2010) Mridu Acharya et al.   JOURNAL OF CLINICAL INVESTIGATION

Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

(2009) D. Q. Tran et al.   BLOOD

Role of β7 Integrins in Intestinal Lymphocyte Homing and Retention

(2009) G. Gorfu et al.   CURRENT MOLECULAR MEDICINE

Membrane protein GARP is a receptor for latent TGF-β on the surface of activated human Treg

(2009) Julie Stockis et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

(2009) Ethan M. Shevach   IMMUNITY

GARP: a key receptor controlling FOXP3 in human regulatory T cells

(2009) M. Probst-Kepper et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GARP (LRRC32) is essential for the surface expression of latent TGF-  on platelets and activated FOXP3+ regulatory T cells

(2009) D. Q. Tran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells

(2009) R. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New regulatory mechanisms of TGF-β receptor function

(2009) Jong Seok Kang et al.   TRENDS IN CELL BIOLOGY

CD4+FoxP3+regulatory T cells confer infectious tolerance in a TGF-β–dependent manner

(2008) John Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

(2008) Marko Pesu et al.   NATURE

Identification of a Regulatory T Cell Specific Cell Surface Molecule that Mediates Suppressive Signals and Induces Foxp3 Expression

(2008) Rui Wang et al.   PLoS One

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology