Loss of Lysosomal Ion Channel Transient Receptor Potential Channel Mucolipin-1 (TRPML1) Leads to Cathepsin B-dependent Apoptosis

Lysosomal storage diseases as disorders of autophagy

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Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma

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Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage

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Cathepsin B Overexpression Due to Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann-Pick Disease

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Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B

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Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

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A Role for the Ca2+ Channel TRPML1 in Gastric Acid Secretion, Based on Analysis of Knockout Mice

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Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel

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Macroautophagy is defective in mucolipin-1-deficient mouse neurons

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A lysosomal–mitochondrial death pathway is induced by solamargine in human K562 leukemia cells

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PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

(2010) Xian-ping Dong et al.   Nature Communications

Neuropathology of the Mcoln1−/− Knockout Mouse Model of Mucolipidosis Type IV

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A Gene Network Regulating Lysosomal Biogenesis and Function

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Enhanced autophagy and mitochondrial aberrations in murine GM1-gangliosidosis

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Molecular and cellular basis of lysosomal transmembrane protein dysfunction

(2008) Raquel Ruivo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal disorders: From storage to cellular damage

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Autophagic dysfunction in mucolipidosis type IV patients

(2008) Silvia Vergarajauregui et al.   HUMAN MOLECULAR GENETICS

TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes

(2008) Fan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Membrane traffic and turnover in TRP-ML1–deficient cells: a revised model for mucolipidosis type IV pathogenesis

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